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Hematology-Oncology Exam 2 > Lymphoma > Flashcards

Flashcards in Lymphoma Deck (40):
1

What is the 7th most common cause of cancer death

Lymphoma

2

Lymphoma has a predominance for M/F?

Males
Although females are more common for follicular lymphoma

3

At what age can lymphoma occur

all ages
avg age is 42

4

3% of what pts will develop lymphoma

AIDS pts

5

Name two probable contributors of why there is an increase in incidence of AIDS pt developing lymphoma

phenoxyherbicide use and aging of pop.

6

80% of lymphomas are from what origin

B-cell

7

What pathogen is associated with Hodgkin's

EBV

8

What is the gold standard for lymphoma diagnosis

excisional biopsy

needle biopsy can be used to determine if a mass is lymphomatous BUT to see the histo of it excisional is best

9

What 3 things do clinicians and pathologist have to communicate clearly about

1. certainty of diagnosis
2. quality of material available for interpretation
3. clinical course going to be taken

10

What is the most characteristic feature of B-cell lymphoma

painless LN enlargement
can have a "rubbry" feel

11

What is the predominant classification of lymphoma

nodal presentation

12

what is nodal presentation

invovlemnt of LN and other lymphoid structures like the liver and spleen

13

what is the extra-nodal presentation

rarer and important to recognize bc treatment may be site specific

14

the Ann Arbor staging stages what?

Hodgkins Disease

15

Ann Arbor staging is ...

limited and extensive

16

Why is Ann Arbor staging used

to differentiate btwn available treatment options

17

what often has microscopic disease at distant sites demonstrated by subsequent relapse

clinically localized low grade lymphoma

18

what has a greater probability of being pathologically localized

higher grade clinically localized lymphoma

it can also turn widespread but if diagnosed quickly and treated it can be cured

19

what is the main reason staging procedures are chosen

to guide therapy selection

20

what was the main criteria of the NCI working formulation classifcation

morphologic

21

which classification system utilized immunophenotypic and genetic data

REAL and WHO

22

what is the translocation for Follicular lymphoma

t(14,18)

23

what is the translocation for Burkitt's lymphoma

t(8,14)

24

what is the translocation for mantle cell lymphoma

t(11,14)

25

what is the survival rate for mantle cell lymphoma

3-5 years

26

what are the diagnostic markers for mantle cell

sIgM+ IgD+
CD19,20,79a+

CD5+ 10+/- 11c- 23- 43+.

27

what is the general main marker for indolent lymphoma

KI67

28

Treatment he bolded for mantle cell

Ibrutinib

29

What type of lymphoma is follicular center

generally indolent with widespread disease

30

What are the markers for follicular center

sIgM+/- IgD+ /-
CD19,20,79a+

CD5- 10+ 11c- 23-/+ 43-.

31

Marginal zone B-cell lymphoma: extra-nodal ?

Low-grade B-cell Lymphoma of MALT type, ( ± monocytoid B cells)

32

Marginal zone B-cell lymphoma: nodal ?

( ± monocytoid B cells)

33

What disease are Marginal zone B-cell lymphoma associated with?

autoimmune disease related (Sjogren’s, Hashimoto’s),
helicobacter related gastric MALT lymphoma.

34

what are the markers for mantle cell

sIgM+/- IgD+ /-
CD19,20,22,79a+

CD5- 10- 11c+/- 23- 43-/+

35

What genetic defect is associated with mantle cell

trisomy 3

36

what kind of lymphoma is mantel cell

indolent and localized
cured with local treatment
can use Ab to treat h. pylori in gastric MALT lymphoma

37

what is used for advanced NHL

CHOP with 3 intensive chemo

38

what is used in relapses of chemo-sensitive NHL

Autologous Bone marrow transplant (Auto-BMT)

39

What is the only approved treatment for low grade lymphoma

Rituxan -monoclonal Antibody therapy
targets CD20

40

what were rituxan's side effects

fever, chills
occurs mainly on first infusion