Lymphoma Flashcards by Selina Campion

Q

BTK resistance

A

C481 mutation confers resistance to covalent BTKi

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Discuss the significance of unmutated vs mutated IGHV in CLL

A

Unmutated IGHV is associated with poorer prognosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the germinal centre markers?

A

CD10, BCL6, LMO2

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Germinal centre DLBCL

A

CD10, BCL6, LMO2

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Activated B cell type DLBCL

A

Constitutive activation of NF-kB and BCR signalling
+ differentiation block preventing maturation past the plasmablast stage

Negative for germinal centre markers

Positive for MUM1 (encoded by IRF4)

Adverse outcomes when compared to GCB type

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly