Lymphoma

Question 1

Lymphoma is malignancies that arise from

Answer 1

Lymph node

Question 2

Types

Answer 2

1. Hodgkin Lymphoma [ Nodular Sclerosis ]
2. Non-Hodgkin lymphoma [Burkitt lymphoma ]

Question 3

most common Hodgkin lymphoma

Answer 3

nodular sclerosis

Question 4

most aggressive Non-Hodgkin lymphoma

Answer 4

Burkitt lymphoma

Question 5

Non-Hodgkin lymphoma most common type

Answer 5

diffuse large B cell lymphoma

Question 6

Burkitt lymphoma tx

Answer 6

rituximab (anti CD20 antibodies

Question 7

Differential between hodgkin and non-Hodgkin

Answer 7

Excisional Lymph node Biopsy
in hodgkin we see :owl sign/reed sternberg cells (large cells with multiple nuclei )

Question 8

prognosis :

Answer 8

hodgkin better prognosis than non

Question 9

Clinical Features

Answer 9

• Persistent Lymphadenopathy typically in cervical or supraclavicular
  region +/- Mediastinal mass in CXR
• Systemic symptoms: - B symptoms: Fever, night sweating , weight loss

Question 10

Suspicious Lymphoma next step ?

Answer 10

1st → Chest – Xray
2nd →Excisional
Lymph node biopsy(definitive )

Question 11

Hodgkin Lymphoma Treatment

Answer 11

Chemotherapy + Radiotherapy [indicated in early stages] till 2nd stage

Question 12

• Chemotherapy drugs used in the treatment of
  Hodgkin Lymphoma

Answer 12

ABVD
A = Adriamycin(doxorubicin)
B = Bleomycin
V = Vinblastine
D = Dacarbazine

Question 13

Non-Hodgkin Lymphoma tx :

Answer 13

Chemotherapy + Radiotherapy [ indicated in early stages]

Question 14

Chemotherapy of Non-Hodgkin Lymphoma

Answer 14

“R-CHOP”
rituximab ,AE: increase hepatitis b
C-cyclophosphamide ,AE: hemorrhagic cystitis (mesna(preventative of cystitis)
O-oncovirin
P-prednisone