Flashcards in Lymphoma Deck (17)
Burkitt's immunophenotype and cytogenetics
surface immunoglobulin +
CD 19, 20, 22 +
Most CD 10+
Lymphoblastic lymphoma immunobiology
B cell: Tdt positive, CD19, CD79a, or CD22 positive. HLA-DR +
T-cell: cytoplasmic or membrane CD3, TdT+, HLA-DR and CD34 negative
What are the risk factors for hodgkins lymphoma?
SES- for those with HL <10yrs associated with low SES and crowding, but in young adults associated with high SES and fewer exposures to children
what are the types of classic HL?
what is the immunophenotype of classic HL
what is the immunophenotype of NLPHL?
what is the definition of constitutional symptoms?
more than 10% weight loss in the last 6mths
drenching night sweats
fever >38C for more than 3 days and unexplained
what factors are associated with more of an adverse outcome in HL?
poor response to therapy
what does brentuximab target?
what cancer can transform in patients with NLPHL?
describe the lugano criteria
1-no uptake above background
2-uptake mediatstinum but liver
5-uptake markedly >liver and or new lesions
1 and 2= CR
4 and 5= active disease
what is the ddx for mediastinal mass?
infection-EBV, atypical mycobacterium, histoplasmosis, toxoplasmosis
malignant- HL, Lymphoblastic lymphoma, DLBCL, ALCL, primary mediastinal Bcell lymphoma, germ cell tumour, soft tissue sarcoma, lymph node met from other sites
what translocation is associated with ALCL?
what translocations are associated with Burkitts lymphoma
what is the immunophenotype of DLBCL?
sIg+, light chain restricted
CD19, CD20, CD22, CD79a, PAX-5 +
Can be CD30+
2/3 express BCL-6
1/3 express cMYC
BCL-6 is expressed by which NHL, and what can it be used to differentiate sometimes between?
BCL-6 is expressed by DLBCL but not by Burkitts