Flashcards in Lymphoma Deck (17)
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1
Burkitt's immunophenotype and cytogenetics
surface immunoglobulin +
TdT negative
CD 19, 20, 22 +
Most CD 10+
Cytogenetics:
(8;14)
(8;22)
(2;8)
2
Lymphoblastic lymphoma immunobiology
B cell: Tdt positive, CD19, CD79a, or CD22 positive. HLA-DR +
T-cell: cytoplasmic or membrane CD3, TdT+, HLA-DR and CD34 negative
7
3
What are the risk factors for hodgkins lymphoma?
Family Hx
EBV infection
SES- for those with HL <10yrs associated with low SES and crowding, but in young adults associated with high SES and fewer exposures to children
social contacts
4
what are the types of classic HL?
Nodular sclerosing
mixed cellularity
lymphocyte rich
lymphocyte depleted
5
what is the immunophenotype of classic HL
CD30+
CD15+ (70%)
CD45 neg
CD20+ (20-30%)
Pax5+
6
what is the immunophenotype of NLPHL?
CD30 neg
CD15 neg
CD45+
CD20+
CD79a +
Pax5 +
7
what is the definition of constitutional symptoms?
more than 10% weight loss in the last 6mths
drenching night sweats
fever >38C for more than 3 days and unexplained
8
what factors are associated with more of an adverse outcome in HL?
advanced stage
B symptoms
bulk disease
poor response to therapy
9
what does brentuximab target?
CD30
10
what cancer can transform in patients with NLPHL?
DLBCL
11
describe the lugano criteria
1-no uptake above background
2-uptake mediatstinum but liver
5-uptake markedly >liver and or new lesions
1 and 2= CR
3-context dependent
4 and 5= active disease
12
what is the ddx for mediastinal mass?
normal thymus
infection-EBV, atypical mycobacterium, histoplasmosis, toxoplasmosis
lymphoproliferative disease
malignant- HL, Lymphoblastic lymphoma, DLBCL, ALCL, primary mediastinal Bcell lymphoma, germ cell tumour, soft tissue sarcoma, lymph node met from other sites
13
what translocation is associated with ALCL?
t(2;5)
NPM-ALK
14
what translocations are associated with Burkitts lymphoma
8;14-most common
2;8
8;22
15
what is the immunophenotype of DLBCL?
sIg+, light chain restricted
CD19, CD20, CD22, CD79a, PAX-5 +
Can be CD30+
2/3 express BCL-6
1/3 express cMYC
16
BCL-6 is expressed by which NHL, and what can it be used to differentiate sometimes between?
BCL-6 is expressed by DLBCL but not by Burkitts
17
