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Flashcards in Lymphoma Stuff Deck (14):
1

PMLE

CD8

2

MC cell in MF

T helper

3

MC COD in MF

Sepsis

4

Prognostic factors in MF

LAD, tumors, ulceration
If all 3 median survival is 1 yr

5

MF may manifest with

TNF inh

6

Incr risk of MF

AD

7

MF markers

Cutaneous lymphocyte ag (CLA) - E selectin ligand, allows traffic into skin

CCR4, another homing molecule

Incr APCs and incr capacity to + T cells

Th1 pattern

more CD8 in early lesions to fight off - more than 20% CD8 in MF have impr survival

Sezary is Th2 which reduces th fxn = incr infection and 2' CA

Low hhv8 has been detected

Cd4+, cd7-, cd26-

8

Forodesine

Inh of purine nucleoside phosphorylase

Pralatrexate - antifolate

9

Zanolimumab

Anti cd4 used in sezary

10

Lennert lymphoma

Resembles GA clinically and histo
Rare cd4 systemic lymphoma

11

Plasmacytoma

MC seen in myeloma (poor prog), may also be associated with tx, extend from bone, poems, Aesop

Anetoderma may show on bx

MC IG is IgG or A

Spicules in MM composed of Abn monoclonal protein

12

Gingival infiltration

AML

13

Congenital leukemia cutis

Unlike other lymphomas cutaneous infiltration does not worsen prognosis

May be complicated by linear calcinosis cutis

14

Polycythemia Vera

Red skin onthe face neck and acral areas
Engorged bluish mm
Telangectasias, epistaxis, bleeding gums, koilonychia
Aquagenic pruritus usually lasts 30-60 min and independent of water temperature - incr of blood and skin histamine