Seb Derm... Flashcards Preview

Dermatology > Seb Derm... > Flashcards

Flashcards in Seb Derm... Deck (17):
1

Pityriasis sicca

Dandruff

2

Seb-derm like eruptions

UL nerve injury causes UL eruption, AIDS, diabetes, malabsorption, epilepsy, neuroleptic drugs like haloperidol, arsenic, gold

3

Pathogenesis of seb derm

Upregulation of IFN gamma, IL6, IL1beta, IL4
Expression of cytotoxicity activating ligand and recruitment of NK cells

More severe=increased density of yeast

4

Effective in seb derm in HIV

Lithium succinate ointment

5

Salmon patches

Nailbed psoriasis

6

Highly suggestive radio graphic PSO findings

Acrosteatolysis - erosions of terminal phalangeal tufts
Tapering
Pencil in cup - cupping of distal phalanges
Predilection for DIP and PIP with sparing of mcp

7

Generalized pustular PSO

Mucous membrane and RDS may occur
Presenting sign of Cushings
Drugs:iodides, tar, mino, terbinafine hydroxychloroquine, acetazolamide, salicylate

8

Late onset PSO

Cw2

9

Palmoplantar PSO

HLA-B8, Bw35, Cw7, DR3

10

PSO associations

Hep C, celiac, lymphoma

11

Promotes IFN gamma

IL-12

12

PSO patho physiology

Reduced IL-10 and IL-1RA
Polymorphisms in IL-10
Rising levels of IL-10 mRNA on therapy
IL-15 triggers inflammatory cell recruitment, angiogenesis, IFN gamma, TNF alpha, IL-17 (proinflammatory)
IL-23 stimulates survival and proliferation of TH17
IL-22 retard keratinocytes differentiation

13

PSO DIF

SC flueoresces with all ab, fibrin, and C'
*same for some candidiasis

14

Salycilate toxicity

Tinnitus, confusion, refractory hypoglycemia; especially in DM and renal

15

Monitoring of mtx liver fibrosis

Procollagen III

16

Adalimimab leflunomide reported to trigger

Reiters

17

Eruption similar to eosinophilic folliculitis seen in

Hep C, allopurinol, pregnancy