Lymphomas

Question 1

Lymphatic system is part of the _____ system

Answer 1

immune

Question 2

Lymphatic system is a network of ____ and ____

Answer 2

vessels and nodes

Question 3

lymph nodes _____ foreign substances, and fight ______

Answer 3

filter foreign substances and fight infections

Question 4

lymph _____ are networks that connect lymph nodes

Answer 4

lymph vessels connect lymph nodes

Question 5

T/F: lymph nodes are located throughout the body

Answer 5

true

Question 6

lymph fluid contain what blood cell?

Answer 6

WBC - to help fight infection

Question 7

what are the 2 types of lymphocytes?

Answer 7

B and T

Question 8

B or T cell lymphocytes destroy germs?

Answer 8

T cell *KILLER T

Question 9

B or T cell lymphocytes create antibodies?

Answer 9

B cell *B = BODIES

Question 10

the lymphatic system is made of cells called ____ which are type of ____ blood cell

Answer 10

lymphocytes; type of white blood cells

Question 11

where are major sites of lymph tissue? (6)

Answer 11

spleen, bone marrow, thymus, adenoids, tonsils, and digestive tract

Question 12

what do spleen and bone marrow have in common?

Answer 12

they both create lymphocytes

Question 13

the ____ helps develop T cells

Answer 13

thymus

Question 14

____ and ____ are a collection of lymph nodes in the throat

Answer 14

adenoids and tonsils

Question 15

T/F: lymphoma can occur almost anywhere?

Answer 15

true

Question 16

what are the 2 main types of lymphoma?

Answer 16

Hodgkins Lymphoma and Non-Hodgkins Lymphoma

Question 17

what is the main histopathology of Hodgkin’s Lymphoma?

Answer 17

-cHL = Classic Hodgkin’s Lymphoma

-subtypes of Classic: Nodular sclerosis, Mixed cellularity, Lymphocyte rich, Lymphocyte depleted

Question 18

What staging system do lymphomas use?

Answer 18

Ann Arbor

Question 19

__ symptoms describe fever, night sweats, and 10% weight loss within six months

Answer 19

B symptoms

Question 20

what is common spread for Hodgkins Lymphoma?

Answer 20

through the lymph system

Question 21

is Hodgkins or Non-Hodgkins more likely to spread distantly?

Answer 21

NHL

Question 22

where is 1st, 2nd, and 3rd distant place Hodgkins lymphoma would spread to?

Answer 22

Liver -> lungs -> bone

Question 23

Hodgkin’s lymphoma can (like NHL) can occur anywhere in body, however where is HL most common to start? Upper or Lower body

Answer 23

Upper - like chest, neck, or underarm area

Question 24

which has a predictable, contiguous (direct) spread? NHL or HL

Answer 24

HL

Question 25

contiguous spread means what?

Answer 25

direct spread/invasion

Question 26

Ann Arbor staging uses the ______ as a point of reference for staging

Answer 26

diaphragm

Question 27

according to Ann Arbor, stages 1 and 2 are limited to areas ___above/below___ the diaphragm

Answer 27

above

Question 28

according to Ann Arbor, stages 3 and 4 are limited to areas ___above/below___ the diaphragm

Answer 28

below

Question 29

which means there are NO symptoms - A or B

Answer 29

A; Asymptomatic

Question 30

which means THERE ARE symptoms - A or B

Answer 30

B

Question 31

what are examples of B symptoms

Answer 31

fever, night sweat, 10% weight loss

Question 32

if a patient has A or B symptoms, which is considered a worse prognosis?

Answer 32

B

Question 33

the ______ infection increases chance of getting Hodgkins Lymphoma

Answer 33

Epstein Barr Infection; EBV

Question 34

what is common chemo to treat Hodgkins Lymphoma?

Answer 34

ABVD (current gold standard); MOPP (original trt)

Question 35

which chemo combo is considered the current gold standard for treating Hodgkins lymphoma?

Answer 35

ABVD

Question 36

Hodgkin's lymphoma is differentiated from Non-Hodgkin's lymphoma how?

Answer 36

HL has Reed Sternberg cells (RS) whereas NHL does NOT have RS cells

Question 37

________ are abnormal lymphocytes that are bi-nucleate (have 2 nucleus)

Answer 37

Reed Sternberg cells

Question 38

what is the most common type/histopathology of Hodgkin's lymphoma?

Answer 38

Classic

Question 39

what is the most common subtype of Classic Hodgkin's Lymphoma?

Answer 39

Nodular sclerosis (NS)

Question 40

what is common radiation field(s) used for Hodgkin's Lymphoma?

Answer 40

Mantle field (treats lymph nodes in chest, neck, and axilla) or Inverted Y (treats lymph nodes in abdomen, pelvis, and spleen)

Question 41

if both mantle and inverted Y are to be treated, what do we call it?

Answer 41

Total Nodal Irradiation (TNI)

Question 42

what is the histopathology of NHL?

Answer 42

B cell lymphoma or T cell lymphoma

Question 43

NHL uses Ann Arbor staging with what classification?

Answer 43

Lugano classification

Question 44

what is common spread for NHL?

Answer 44

through lymph system

Question 45

which one, HL or NHL, spreads randomly and in no specific order?

Answer 45

NHL

Question 46

which lymphoma is likely to occur in the following areas - lymph nodes, GI tract/peyers patches, and Waldeyer's ring

Answer 46

NHL

Question 47

which lymphoma - HL or NHL, is more common in older patients?

Answer 47

NHL

Question 48

what chemo combo is used to treat NHL?

Answer 48

CHOP

Question 49

which NHL is most common T cell or B cell?

Answer 49

B cell

Question 50

NHL can be classified by their _________

Answer 50

aggressiveness

Question 51

describe spread of an indolent lymphoma -

Answer 51

spread and grow slowly, might not need treatment right away, fewer symptoms

Question 52

what is most common aggressive lymphoma?

Answer 52

diffuse large B cell lymphoma

Question 53

Lugano system is based 1-4 and an ___ is added when organs outside the lymphatic system are involved

Answer 53

E