lymphomas Flashcards
(15 cards)
burkitt lymphoma
clinical presentation of sporadic form in burkitt lymphoma
abdominal or pelvic organ infiltration by neoplastic B-cells
* abdominal distention
* constipation
* back pain
burkitt lymphoma
clinical findings in endemic form of burkitt lymphoma
- positive heterophile antibodies
* atypical lymphocytes
proliferation of B-cells with scattered macrophages
** “starry sky”
translocation in burkitt lymphoma
t(8;14)
c-myc proto-oncogene (chromosome 8) - Ig heavy chain (chromosome 14)
B cell proliferation
translocation in follicular lymphoma
t(14;18)
BCL2 gene in chromosome 18 - Ig heavy chain in chromosome 14
B- cell lymphomas
indolent (low-grade) lymphomas
- follicular lymphoma
- hairy cell leukemia
- marginal zone B-cell lymphoma
- small lymphocytic lymphoma
B-cell lymphomas
Aggressive (high grade) lymphomas
- diffuse large B-cell lymphoma
- mantle cell lymphoma
- burkitt lymphoma
B-cell lymphomas
mutations in diffuse large B-cell lymphomas
Bcl-2, Bcl-6, p53
aggressive B-cell lymphoma
spreads rapidly, CD5+, t(11;14), increased levels of cyclin D1 and heavy chain Ig, most patients diagnosed at advanced stages
mantle cell lymphoma
aggressive (high grade) B-cell lymphomas
very aggressive tumor of B cells that usually arises at extranodal sites
Burkitt lymphoma
aggressive B-cell lymphoma
phenotype Burkitt lymphoma
CD19+, CD20+, CD10+, BCL6+, IgM+
BCL2-
B cell lymphomas
BRAF mutations
hairy cell leukemia
B-cell lymphoma
mutations in CREBBP, EZH2, KMT2D (MLL2) –> chromatin remodelling
follicular lymphoma
high grade B-cell lymphoma
mutation in MYD88, CD79B, NOTCH1/2, EZH2, BCL2, BCL6, MYC
diffuse large B-cell lymphoma
high grade B-cell lymphomas
phenotype for diffuse large B-cell lymphoma
- CD10+
- CD19+
- CD20+
- BCL-6+
- BCL-2+
- MYC+
B-cell lymphomas
phenotype for mantle cell lymphoma
Cyclin D1+, CD19+, CD20+, CD22+, CD5+, CD10-, CD23-
