M5 L2

Question 1

Can you describe the transcription activation by transduction as a response to VIRAL infection?

Answer 1

• Interferon Y binds to interferon Y receptor on cell surface membrane
• This causes the receptor to couple up with JAK KINASE
• JAK kinase phosphorylates STATIN 1 monomer converting it into STATIN 1 dimer
• Statin 1 phophorylated dimer

Question 2

Can you describe Transduction of CREB in terms of cAMP?

Answer 2

• Hormone binds to receptor on cell surface membrane
• This causes hormone receptor to couple with Adenylate cyclase
• Adenylate cyclase CONVERTS ATP into cAMP
• cAMP activates protein kinase
• Protein kinase migrates to nucleus and PHOPHORYLATES CREB transcription factor
• This allows CREB to interact with its factor CRB and initiate transcription

Question 3

Can you describe transduction of HYDROPHOBIC SMALL HORMONES STEROID?

Answer 3

• Steroid directly diffuses through membrane and bind to receptor
• Steroid binds to glyCORTICOID receptor inside cell causing dimerization of these receptor
• glyCORTICOID DIMER moves into nucles
• transcription is intitiated