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Major Non-ABO Blood Groups Flashcards

(54 cards)

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1
Q

ISBT 016

A

LW blood group

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2
Q

Expressed together with Rh

A

Lw

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3
Q

LW gene is on what chromosome

A

Chromosome 19

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4
Q

LW antigen is carried by

A

Intracellular Adhesion Molecule 4

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5
Q

To differentiate D Ag from LW Ag

A

Treat cells with DTT
D Ag: Not denatured
LW Ag: Denatured

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6
Q

Anti-LW will react ____ with most D (+) cells

A

Strongly

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7
Q

Anti-LW will ____ with Rh (-) cells

A

Weakly

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8
Q

Anti-LW will _____ react with Rh null cells

A

Never react

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9
Q

Anti-LW will react ____ with cord cells regardless of D type

A

Equally

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10
Q

Only major system not produced by RBCs

A

Lewis system

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11
Q

Lewis Ag are found on ____ passively absorbed by RBCs in plasma

A

Type 1 glycosphyngolipids

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12
Q

Le gene is found on what chromosome

A

Chromosome 19

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13
Q

FUT3 gene

A

Le gene

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14
Q

Type of sugar derivative of Le Ag found in secretions

A

Glycoproteins

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15
Q

Type of sugar derivative of Le Ag absorbed by RBCs in plasma

A

Glycolipid

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16
Q

Le (a+b+) is possible in what race

A

Asians

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17
Q

lele is common in

A

Blacks

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18
Q

T/F: Lewis Ag not present at birth, not expressed on cord cells

A

T

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19
Q

Le Ag development in Secretor

A

Le(a-b-) > Le(a+b-) > Le(a+b+) > Le(a-b+)

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20
Q

Le Ag development of Non-secretor

A

Le(a-b-) > Le(a+b-)

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21
Q

When is Leb Ag present?

A

If Le and Se are present

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22
Q

Genes Inherited: Le Se ABH
Substance in Secretions:
Red cell Phenotype:

Study These Flashcards
A

Lea, Leb, ABH
Le(a-b+) ABH

23
Q

Genes Inherited: lele Se ABH
Substance in Secretions:
Red cell Phenotype:

Study These Flashcards
A

ABH
Le(a-b-) ABH

24
Q

Genes Inherited: Le sese ABH
Substance in Secretions:
Red cell Phenotype:

Study These Flashcards
A

Lea
Le(a+b-) ABH

25
Genes Inherited: lele sese ABH Substance in Secretions: Red cell Phenotype:
None Le(a-b-) ABH
26
Genes Inherited: Le sese AB hh Substance in Secretions: Red cell Phenotype:
Lea Le(a+b-) Oh/H null (bombay)
27
Genes Inherited: Le sese AB hh Substance in Secretions: Red cell Phenotype:
Lea Le(a+b-) Oh/H null (bombay)
28
Genes Inherited: Le Se AB hh Substance in Secretions: Red cell Phenotype:
Lea, Leb, ABH type 1 Ag Le(a-b+) Ah or Bh (parabombay)
29
Anti-Lea, Anti-Leb 1) IgM 2) Naturally occuring 3) Cold reactive A. 1 B. 1,2&3 C. 1&3 D. 1&2
B.
30
Leb is associated with
H. Pylori infection
31
MNS gene is found in what chromosome?
Chromosome 4
32
Antigens of MNS system
M, N, S, s
33
Paternity tested Ag
MNS
34
Stronger reactions demonstrated from an antibody to a homozygous cell than a heterozygous cell
Dosage effect
35
Location of MN Ag
Glycophorin A
36
M and N differ at position 1 and 5 with what amino acids?
M: 1-serine; 5-glycine N: 1-leucine, 5-glutamic acid
37
Location of Ss Ag
Gylcophorin B
38
S and s Ag differ at position 29 with what amino acid?
S: methionine s: threonine
39
S+s+ what phenotype?
U phenotype
40
MNS antibodies are in nature what?
IgM, naturally occuring and cold reactive
41
Anti-M react at pH
pH 6.5 (acidic)
42
Anti-N react at pH
alkaline pH
43
Antibody sterilized with formaldehyde
Anti-Nf
44
Anti-S & Anti-s in nature
IgG; reactive 37oC & AHG phase
45
S-s-
Anti-U
46
Anti-U is common in
Blacks
47
GPA is recepector for
E. coli
48
GPA and GPB receptor for
Plasmodium falciparum
49
ISBT 002
MNS system
50
ISBT 003
P blood group
51
Ag that deteriorates rapidly upon storage
P1 Ag
52
Phenotype: P1 Ag: Ab:
P1, P, Pk None
53
Phenotype: P2 Ag: Ab:
P, Pk Anti-P1
54
Phenotype: p (P null) Ag: Ab:
None Anti-PP1Pk/Anti-Tja

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