Rh Blood Group

Question 1

Most complex red cell antigen system

Answer 1

Rh blood group

Question 2

RhD and RhCE genes proposed by

Answer 2

Patricia Tippett

Question 3

Location of RhD and RhCE gene

Answer 3

Chromosome 1

Question 4

Location of RhAG gene

Answer 4

Chromosome 6

Question 5

Controls expression of RhD, RhCe, RhcE, RhCE, Rhce

Answer 5

RhD and RhCE genes

Question 6

Co-expressor but itself cannot express any Rh antigen

Answer 6

RhAG gene

Question 7

Presence of 3 separate genes linked on the same chromosome and are inherited as a group of 3

Answer 7

Fisher-Race

Question 8

A single locus on a gene carries entire Rh system

Answer 8

Weiner

Question 9

DCE nomenclature

Answer 9

Fisher-Race

Question 10

Rh-Hr Terminology

Answer 10

Wiener

Question 11

DCe

Answer 11

R1

Question 12

DcE

Answer 12

R2

Question 13

DCE

Answer 13

Rz

Question 14

dcE

Answer 14

r”

Question 15

dCe

Answer 15

r’

Question 16

dCE

Answer 16

ry

Question 17

R0r

Answer 17

Dce/dCe

Question 18

R1R2

Answer 18

DCe/DcE

Question 19

R1r”

Answer 19

DCe/dcE

Question 20

Rzr

Answer 20

DCE/dce

Question 21

R2r’

Answer 21

DcE/dCe

Question 22

r’r”

Answer 22

dCe/dcE

Question 23

R0
Fisher-Race:
Blood factors:

Answer 23

Dce
Rh0hr’hr”

Question 24

R1
Fisher-Race:
Blood factors:

Answer 24

DCe
Rh0rh’hr”

Question 25

R2 Fisher-Race: Blood factors:

Answer 25

DcE Rh0hr’rh”

Question 26

Rz Fisher-Race: Blood factors:

Answer 26

DCE Rh0rh’rh”

Question 27

r Fisher-Race: Blood factors:

Answer 27

dce hr’hr”

Question 28

r’ Fisher-Race: Blood factors:

Answer 28

dCe rh’hr”

Question 29

r” Fisher-Race: Blood factors:

Answer 29

dcE hr’rh”

Question 30

ry Fisher-Race: Blood factors:

Answer 30

dCE rh’rh”

Question 31

Most common in Blacks

Answer 31

R0r

Question 32

Most common in Asian/Whites

Answer 32

R1r

Question 33

Four most common genotypes

Answer 33

R1, R2, r, R0

Question 34

African-American common genotype

Answer 34

R0 > r > R1 > R2

Question 35

Caucasians common genotype

Answer 35

R1 > r > R2 > R0

Question 36

System that assigns a number to each antigen in order of its discovery or recognized relationship to Rh system

Answer 36

Rosenfield

Question 37

Alpha-numeric terminology

Answer 37

Rosenfield

Question 38

Rh1

Answer 38

D

Question 39

Rh2

Answer 39

C

Question 40

Rh3

Answer 40

E

Question 41

Rh4

Answer 41

c

Question 42

Rh5

Answer 42

e

Question 43

R1r Fisher-Race: Rosenfield: Common or Rare

Answer 43

DCe/dce 1,2,-3,4,5 Common

Question 44

R1R1 Fisher-Race: Rosenfield: Common or Rare

Answer 44

DCe/DCe 1,2,-3,-4,5 Common

Question 45

rr Fisher-Race: Rosenfield: Common or Rare

Answer 45

dce/dce -1,-2,-3,4,5 Common

Question 46

R1R2 Fisher-Race: Rosenfield: Common or Rare

Answer 46

DCe/DcE 1,2,3,4,5 Common

Question 47

R2r Fisher-Race: Rosenfield: Common or Rareo

Answer 47

DcE/dce 1,-2,3,4,5 Common

Question 48

R2R2 Fisher-Race: Rosenfield: Common or Rare

Answer 48

DcE/DcE 1,-2,-3,4,-5 Common

Question 49

r’r Fisher-Race: Rosenfield: Common or Rare

Answer 49

dCe/dce -1,2,-3,4,5 Rare

Question 50

r’r’ Fisher-Race: Rosenfield: Common or Rare

Answer 50

dCe/dCe -1,2,-3,-4,5 Rare

Question 51

r”r Fisher-Race: Rosenfield: Common or Rare

Answer 51

dcE/dce -1,-2,3,4,5 Rare

Question 52

r”r” Fisher-Race: Rosenfield: Common or Rare

Answer 52

dcE/dcE -1,-2,3,4,5 Rare

Question 53

R0r (R0R0) Fisher-Race: Rosenfield: Common or Rare

Answer 53

Dce/dce (Dce/Dce) 1,-2,-3,4,5 Rare

Question 54

r’r” (ryr) Fisher-Race: Rosenfield: Common or Rare

Answer 54

dCe/dcE (dCE/dce) -1,2,3,4,5 Rare

Question 55

D ISBT:

Answer 55

004001

Question 56

C ISBT:

Answer 56

004002

Question 57

E ISBT:

Answer 57

004003

Question 58

c ISBT:

Answer 58

004004

Question 59

e ISBT:

Answer 59

004005

Question 60

First 3 number of ISBT represents

Answer 60

the system collection and series

Question 61

Last 3 numbers of ISBT represents

Answer 61

antigenic specificity

Question 62

Rh antigens are well developed at birth and therefore easily cause ____

Answer 62

HDN

Question 63

Anti-D incompatible %: compatible %:

Answer 63

85% 15%

Question 64

Anti-C incompatible %: compatible %:

Answer 64

70% 30%

Question 65

Anti-E incompatible %: compatible %:

Answer 65

30% 70%

Question 66

Anti-c incompatible %: compatible %:

Answer 66

80% 20%

Question 67

Anti-e incompatible %: compatible %:

Answer 67

98% 2%

Question 68

Weak D (Du) is common in what race?

Answer 68

Blacks

Question 69

Weak D is detected by

Answer 69

IAT

Question 70

Allele carrying RhD is in trans position to the allele carrying C

Answer 70

C in trans to RhD/ Positional D

Question 71

D antigen is expressed completely but fewer in numbers. Rarely makes anti-D sinces changes are inside RBCs

Answer 71

Genetic weak D

Question 72

One or more epitopes within the D antigen is missing altered

Answer 72

Partial D/D mosaic

Question 73

Partial D donor is considered

Answer 73

Rh (+)

Question 74

Partial D recipient is considered

Answer 74

Rh (-)

Question 75

D—/D—

Answer 75

Rh deletion

Question 76

—-/—-

Answer 76

Rh null

Question 77

Normal RhD & RhE genes RhAG expression

Answer 77

Regulator Rh null

Question 78

Normal RhAG gene Mutated RhCE Deleted RhD

Answer 78

Amorphic Rh null

Question 79

Partial suppression of Rh gened caused by RhAG mutation

Answer 79

Rh mod

Question 80

Compount antigen when c and e are in cis position

Answer 80

f (c,e)

Question 81

Caused by single amino acid change on RhCE protein

Answer 81

Cw

Question 82

Compound antigen when C and e are present

Answer 82

Rhi (Ce)

Question 83

Present on D+C-/D-C+/D+C+ Not on D-C-

Answer 83

G (DC)

Question 84

Strong expression of D because of Cc/Ee expression

Answer 84

Exalted D

Question 85

Not naturally occuring antibodies and only form upon exposure such as pregnancy and transfusion

Answer 85

Rh antibodies

Question 86

Igs of Rh antibodies that are warm reacting and reacts at 37oC

Answer 86

IgG

Question 87

Most clinical significant IgG in Rh

Answer 87

IgG1 & IgG3

Question 88

Complement fixation IgG in Rh

Answer 88

IgG3 > IgG1 > IgG2

Question 89

Non-complement binding IgG in Rh

Answer 89

IgG4

Question 90

Best Rh IgG at crossing placenta

Answer 90

IgG1 > IgG4 > IgG3

Question 91

Rh IgG that cannot cross placenta

Answer 91

IgG2

Question 92

Most dominant Rh IgG in adults

Answer 92

IgG1 > IgG2 > IgG3 > IgG4

Question 93

HTRs due to Rh incompatibilities usually results in

Answer 93

Extravascular hemolysis in the liver and spleen

Question 94

How much of the exposure to Rh (+) can stimulate antibody production in an Rh (-)

Answer 94

0.1 mL

Question 95

Warm Rh autoantibodies appears to what antibody specificity

Answer 95

Anti-E like specificity

Question 96

Warm Rh autoantibodies appears to what antibody specificity

Answer 96

Anti-E like specificity