Male Fertility Drugs Flashcards
(24 cards)
Testosterone
DHT
Methyltestosterone
Fluoxymesterone
{MOA}
C/U
Testosterone/androgen R agonist as intracytosolic R to be used in the nucleus and get nuclear gene transcription regulation increased
C/u:
Adult Hypogonadism (M)
Delayed puberty (M)
Differentiation into secondary sex characteristics
–> T differentiate vas difference, epididymis, seminal vesicles, penis, deeper voice
–> DHT: Penis, balls, prostate, Baldness
Testosterone
DHT
Methyltestosterone
Fluoxymesterone
S/E
+Gynocomastia
+Gonadoatrophy via low LH and FSH release
+Infertility
+Mascuilinization of F
+Ance
+LOW HDL; HIGH LDL
Testosterone
DHT
Methyltestosterone
Fluoxymesterone
CONTRAINDICATIONS
X-Pregnancy (Uterus masculinization)
X-Youth kids/teens
X-Breast and Prostate Carcinoma
X-Heart Disease
ANABOLIC STEROID»»OXANDROLONE
[Oxandrolone:]
MOA:
C/U
S/E:
MOA:
Increased ratio of anabolic to androgenic activity
C/U:
+Catabolic states
+Renal insufficiency
+Performance enhancers in athletes
+Anabolic stimulation post severe trauma, infection, surgery, etc.
+Androgen responsiveness to recurrent Mammilary cancer postmenopausal F)
S/E:
1) Testicular atrophy
2) M infertility
3) Gynocomastia
4) LOW HDL; HIGH LDL
5) Liver Toxicity
MOA of Danazol
Synthetic androgen recetor agonist (Affinity: Androgen>Progesterone; Glucocortoroid> Estrogen)
Suppress endometrial estrogen and progesterone receptors
Danazol is a (class)
Androgen agonist
Danazol uses
Hereditary angioedema
Uterine leiomyoma
Endometriosis
Danazol S/E
Weight gain, edema
Acne
Hirsutism
↓ HDL levels
Hepatotoxicity
Idiopathic intracranial hypertension
Danazol Contraindications
1) Pregnancy
2) Breast Feeding
3) Genital Bleeding
4) Heart, Kidney, Liver, Porphyria
Antiandrogen Drugs (7)
1) -Relix
2) -Relin
3) Ketoconazole
4) Spironolactone
5) Finasteride
6) Flutamide
7) Cyproterone
Abiraterone MOA, C/U, S/E
17a-hydroxylase Inhibitor for PROSTATE CANCER leading to HTN, Low K from High Aldosterone
Finasteride, Dutasteride MOA, C/U, S/E
[MOA]:
5a- hydroxylase inhibitor to stop conversion from TESTOSTERONE to DHT in
[c/u]:
BPH,
Male pattern baldness.
[s/e]:
Sex dysfunction Gynecomastia.
Tamsulin MOA and C/U
A1A/D receptor blocker is used to treat BPH so not get smooth muscle contraction.
Drugs for BPH
Finasteride/ Dutasteride and Tamsulosin
FLutamide, Bicalutamide, Cyproterone, Spironolactone
MOA
C/U
S/E
[moa]:
Competitive Nonsteroid androgen antagonist –> DECREASE steroid binding
[cu]:
GnRH analog for Prostate Cancer
[s/e]:
Gynocomastia
Impotence
Hot flashes
Hep
MALE SEXUAL DYSFUNCTION CONSISTS OF THE FOLLOWING:
1) LOW LIBIDO
2) ED
3) ABNL EJ
4) DYSPANEURIA (genital pain that occurs just before, during or after sex)
*SEX AND BONERS
MALE SEX DYSFUNCTION CAUSES
+AGE
+LOW TESTOSTERONE/ HIGH PROLACTIN
+SPINE INJURY
+ATHEROSCLEROSIS
+DM
+CKD
+CLONADINE, METHYLDOPA, BB, DIURETICS (THIAZIDES, SPIRONOLACTONE), SSRI,
+ETOH
+5A REDUCTASE INHIBITORS
+KETOCONAZOLE/CIMENTADINE
+DEPRESSION/ ANX
+
M SEX DYSFXTN RX
TESTOSTERONE (ENHANCE LIBIDO VIA KEEPING NO SYNTHASE) AND PDE-5 INHIBITORS (SIDINAFIL, TADALAFIL, VARDENAFIL) [INCREASE CAMP FOR INCREASING BLOOD FLOW IN CORPUS CAVERNOSUM; PENILE ERECTION]
PDE5 INHIBITOR S/E
HEADACHE
BLUE VISION
FLUSHING
HYPOTN
DYSPEPSIA
DONT GIVE PDE5 INHIBITORS WITH — BECAUSE
NO FOR DERVEVRE HYPOTN
CYP3A4 INHIBITORS- CLARITHROMYCIN, KETOCONAZOLE, INDINAVIR, VERAPAMIL
RX FOR PEYRONIE’S DISEASE (4)
1) PENTOXIFYLLINE - PDE INHIBITOR
2) COLLAGENASE (PLAQUE SIZE REDUCTION)
3) COLCHACINE (ANALGESIC)
4) VIT E (ANTIOXIDANT)
ED RX
Premature ejaculation: Early ejaculation, loss of control, psychological distress
Rx.
SSRI 1st line treatment (Paroxetine, Fluoxetine)
TCA 2nd line treatment (Clomipramine)
PDE-5 inhibitors in patients with ED
Topical anesthetics (Lidocaine + prilocaine spray)
Alprostadil cream
Anejaculation:
Lack of ejaculation in men with lower urinary tract syndrome (LUTS)
Rx. Tamsulosin, Alfuzosin
Testicular Cancer RX
REGAMINE IN CYCLES (3-4W) FOR RECOVERY: BEP-EP-VIP
Cisplatin- OTO, NEPHRO, NEURO
Etoposide
Bleomycin- PUL FIBROSIS
Ifosfamide
DOCE/Paclitaxel- NEURO, BMS
Vinblastine- BMS
Drugs for Prostate Cancer
A
