RENAL REPLATED PHARM

Question 1

WHERE DO THIZIDES ACT?
NAME THEM

Answer 1

DCT
HYDROCHLOROTHIZIDE
CHLOROTHIAZIDE
CHLOROTHIADONE
INDEPAMIDE
METROLAZONE

“CHLORINATED WATER IS INDEPENDENDENT OF THE METRO”

Chlorinated==>
CHLOROTHIZAIDE
CHLOROTHIADONE

WATER==>
HYDROCHLOROTHIAZIDE

IS INDEPNDENT==>
INDEPAMIDE

FROM THE METRO==>
METROLAZONE

Question 2

WHERE TO OSMOTIC DIRECTS ACT?
NAME THEM!

Answer 2

MANNITOL
UREA
GLYCERINE
ACTS ON PCT AND DECENDING LOOP OF HENLE

Question 3

WHERE DO CARBONIC ANHYDROGENGASE INHIBITORS ACT?
NAME THEM!

Answer 3

ACTEZOLAMIDE; AT THE PCT

Question 4

WHERE DO THE LOOP DIURETICS DIRECT ACT
NAME THEM

Answer 4

FURUSEMIDE
BUDESONIDE
ETHRACRYCIN
TORUCEMIDE

NA/K/ 2CL CHANNELS OT LOOP OF HENLE

Question 5

WHO IS AT RISK FOR NEPHROTOXICITY

Answer 5

+OLD PPL
+DEHYDRATION
+PREEXTISTING KIDNEY DISEASE
+MULTIPLE DRUG USE
+HEART/LIVER FAILURE

Question 6

NEPHROTOXICITY CAN BE WHAT 3 PARTS?

Answer 6

PRE/INTRA/POST RENAL

PRE: BEFORE KIDNEY, TUBULES WORKING
INTRA: TUBULES DAMAGED, NO WORKING
+AIN
+ATN
+GD
POST: AFTER KIDNEY SEE OBSTRUCTION

Question 7

WHAT DRUGS CAUSE PRE-RENAL AZOTEMIA?

Answer 7

[DIA RNA]:

[D:] DIURECTIS W W/O ANTI-HTN
[I:] IMMUNOSUPPRESANTS
[A:] ARTERIAL VASODILATORS –> ACE I CAUSE VASODILITATION OF EFFERENT ARTEROLE, CAUSING DECREASE INTRAGLOMERULAR PRESSURE AND GFG

[R:] RADIO CONTRAST
[N:] NSAIDS–> BLOCK PG SYNTEHIS SO CONSTRICTS AFFERENT AFTERIAL, DECRESE BF TO GLOMERULUS
[A:] ANTICOAGULANTS/ THROMBOLYTICS

Question 8

WHAT REGULATES & INHIBITS VASODILATATION OF THE AFFERENT ARTEROLE?

Answer 8

+PG
-NSAIDS –> NO VASODIALATE

Question 9

WHAT REGULATES AND INHIBIT EFFERNECT ARTEROLE?

Answer 9

+ACE
-ACE INHIBITOR–> NO VASOCONSTRICTION, YES TO VASODIALATE

Question 10

Drugs that cause the PRE renal Injury?

Answer 10

Drug with or w/o ANTI-HTN
Immunosuppressants
Arteriole Vasodilators (ACE inhibitors)

Radio contrast
NSAID
Anti-cog/thrombolytics

Question 11

Drugs that cause POST renal Azotemia

Answer 11

A- Acyclovir
I- Indinavir
M- MTX
S- Sulfulnamides

Question 12

Drugs that Cause Rhabdomyolysis

Answer 12

Fibrates

Zidovudine
Antipsychotics
Azathioprine
Lithium
Statins

“F ZAAL’S muscles”

Question 13

Metoprolol to RAAS

Answer 13

DECREASE Renin
DECREASE Aldosterone
NL Bradykinin

Question 14

Acute Intrinsic Necrosis inducing drugs names

Answer 14

*Penicillin- vancomycin, ticarcillin, ampicillin
Ceophosporin
QUinidines
H2 Receptor antagonists
Proton Pump Inhibitors

Question 15

ATN/ AKI inducing Drugs

Answer 15

(FAMily CAT)

Foscarnet
*AMinoglycosides

Cisplatin
*Ampho B
Tenofovir

Question 16

Rapidly Progressive Glomerular Nephritis Indicug drugs

Answer 16

D- Penicillamine
Hydralazine
PTU