Mantle Cell lymphoma

Question 1

What type of lymphoma is mantle cell?

Answer 1

B-cell lymphoma

Question 2

What translocation is implicated in Mantle Cell Lymphoma?

Answer 2

associated translocation (11;14)
=> over-expression of the cyclin D1 (BCL-1) gene

Question 3

What CD markers are present in Mantle Cell Lymphoma

Answer 3

CD5+, CD19+, CD22+

Question 4

How do patients typically present with Mantle Cell Lymphoma?

Answer 4

Widespread lymphadenopathy

Question 5

Does mantle cell lymphoma usually have a good or bad prognosis?

Answer 5

Poor prognosis