Marijuana Flashcards
Key components of marijuana
delta9 THC
cannabidiol
cannabinol
Marijuana
dried leaves and flowers
Hashish
compressed stalked resin glands from cannabis flower blossoms
1937
congress passes marijuana tax act
1996
California passes prop 215 becoming first legal medical marijuana state
2013
Cole memo creates hands-off policy for legal medical marijuana
2014
Obama signs farm bill allowing hemp to be cultivated for research
2018
Farm bill passes legalizing hemp and CBD oil
Endocannabinoid System (ECS)
- Receptors
- Ligands
- Transporters
- Enzymes
Effects of Endocannabinoids
Retrograde regulators of neurotransmission inhibiting the release of GABA and glutamate
THC is a partial agonist at the CB1R while synthetic cannabinoids are full agonists
CB1
predominantly in the brainstem
low levels of respiratory centers in brainstem
Less risk of respiratory depression,coma
CB2
predominantly in the peripheral
recruit immune cells and activate dendritic cells
B and T cells
Cannabidiol pharmacology and use
Low affinity for CB receptors
May antagonize THC at CB1
Lacks euphoric effects
< 0.3% THC legal in IN
Most commonly used for pain–> not supported by trials
Association between cannabis and mental health disorders
Difficult to prove and very controversial
Growing evidence for association with schizophrenia–> NO CAUSE AND EFFECT
Risk factors for psychosis: age of use onset, potency
Cannabinoid hyperemesis syndrome
Cyclic vomiting, abdominal pain
Presentation after prolonged and excessive use
Relief by sustained cessation
Associated with hot showers/baths
Cannabis cessation
BZDs
Haloperidol
Capsaicin cream
