Psychostimulant misuse

Question 1

Describe the current trends in stimulant overdose death

Question 2

Differentiate between psychostimulants based upon the neurotransmitter affected by their administration

Question 3

Describe the primary clinical effects of psychostimulants with escalating dose

Question 4

Discuss the effect of chronic psychostimulant use on the CNS dopaminergic system

Question 5

Describe why pseudoephedrine is regulated to reduce methamphetamine abuse

Answer 5

Pseudoephedrine reduces OH to H–> methamphetamine

Although many sources of methamphetamine is not coming from this process, the escalation of meth overdose is

Which is saying even though there are regulations of OTC pseudoephedrine behind the counter there is still an escalation in meth overdoses

Question 6

Identify the primary manifestations of sympathomimetic toxidrome

Question 7

Nicotine vs. Ach

Answer 7

Similarities in structure:
-charged amino group
-hydrogen bond receptor groups

Nicotine is not degraded by acetylcholinesterase–> more potent, longer duration

Question 8

Partial agonist therapy for nicotine addiction

Answer 8

causes release of dopamine
highly addictive
NRT relatively is ineffective alone
Vereciline partial agonist increases quit rate success

Question 9

Fenethylline

Answer 9

Amphetamine + theophylline–>linker–>fenethylline

Question 10

Effects of methamphetamine abuse

Answer 10

Delirium, tremor

Anxiety, paranoia, hallucinations, delusions, repetitive behavior

Dental decay

Tachycardia, hypertension

Diaphoresis

Question 11

Sympathomimetic toxidrome

Answer 11

avoid pure BB for tx

MATHS
MYDRIASIS
AGITATION, ARRHYTHMIA, ANGINA: BZD
TACHYCARDIA
HYPERTENSION, HYPERTHERMIA
SWEATING, SEIZURE: BZD