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Flashcards in Materials / Bruce's Final Prep Deck (37)
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1

Durometer

Hardness of tubing

2

Spallation

Cracking failure especially at point of flexion

3

Memory

Flexibility and resilience

4

Wear was invariably found on the luminal surfaces at the junction of

-inner and outer walls of PVC and silicone rubber tubing -no differences between normal and tight occlusions

5

The grooves in the PVC tubing were narrow and continuous with occasional deep cracks in the tubing after

> 3 hrs. on pump

6

Tygon material after 3.67 million compressions at full occlusion

crack formation did not occur

7

If the Tygon tubing was over-occluded, cracks did appear within ____.

24 h

8

A visible change of tubing diameter was generally noticeable by around 250 psi of arterial line pressure, which was already very high. By 1,500 psi what were the results of PVC and Silicone ?

PVC diameter ↑ by 5% to 10%
Silicone rubber tubings diameter ↑ between 20% to 25%

9

Silicone rubber tubings of all sizes showed?

greater distensibility than PVC tubings of equivalent size

10

1 PSI =

52 mmHg

11

Filtered reservoirs included 3 things?

-Sponge filter
-defoaming agent
-Screen filters

12

Unfiltered reservoirs are known as what ?

Collapsible bags

13

Historic filters were made of what ?

Dacron, wool, felt and nylon screens.

14

Current ECC Materials ?

-- Polyvinylchloride
– Polycarbonate
– Polypropylene

-- Stainless Steel

15

INFLAMMATION: Initiators-

-Systemic cytokine
signaling and -compliment system
activation
-Expression of cell
adhesion molecules

16

INFLAMMATION:
Effectors-

Margination of neutrophils, monocytes and platelets Release of granule proteases

17

INFLAMMATION by
Effectors-
&
Initiators
can lead to what ?

Organ Failure:

18

SIRS =

Systemic Inflammatory Response System

19

Cytokine =

Molecules released from inflammatory cells
that are signaling agents.

20

ATN

Acute Tubular Necrosis which results from
↑ surface contact
↑ hemolysis
= organ failure.

21

Coagulation /
Fibrinolysis cascade

1:17

Biological cascade influenced by contact of blood with a foreign surface.

22

Compliment activation
proteins (5)

1:19

C5
C6
C7
C8
C9
less compliment proteins is good

23

Complement proteins lead to what ?

1:20

a hole in the cell membrane leading to destruction of the cell

24

Ways of reducing contact activation ?

1:21

–Smaller components –Reduced air interface

25

4 Surface Treatments by
Heparin bonding

– Carmeda
– Duroflow
– Bioline
– Trillium

26

4 Surface Treatments by Surface modification

– SMART
– PC
– X-coating
– Softline

27

Carmeda

Covalent end- point attachment of heparin to ECC surface

does not wash off

28

Duroflow

Ionic end-point attachment of heparin to ECC material

washes off

29

SMART




1:28

• Cobe Product
• Molecule added to the plastic before extrusion - passively moves to surface of material
• Alternating hydrophobic and hydrophilic surfaces
• Designed to occupy all of fibrinogens binding sites, disabling it from binding platelets

30

Trillium




1:30

Binds a linker molecule to the PVC then binds heparin and other molecules to the linker to create a heparinized boundary layer