MCAT Bio Flashcards
What is produced from the decarboxylation of pyruvate? When does this occur?
1 NADH is produced for the decarboxylation of each pyruvate. This happens as a preparatory step before the Kreb’s Cycle.
How many ATP and NADH are generated from glycolysis?
2 ATP
2 NADH
What is produced during the Kreb’s cycle?
Per each pyruvate:
6 NADH
2 FADH2
2 ATP
What receives the electrons at the end of the electron transport chain?
Oxygen is the final e- recipient.
2H + 2e + 1/2O => H2O
How many ATP does each NADH make? Each FADH2?
Each NADH makes 3 ATP.
Each FADH2 makes 2 ATP.
Why does FADH2 make fewer ATP than NADH?
FADH2 starts later in the electron transport chain. It goes straight to Complex II and ubiquinone instead of starting at Complex I.
How many ATP does NADH from the matrix make? From the cytoplasm? Why?
NADH from matrix makes 3 ATP.
NADH from cytoplasm makes 2 ATP. This is because some of the energy in the NADH is used for the transporters that bring the NADH into the mitochondria.
Where does glycolysis happen? The TCA Cycle? Electron Transport Chain?
Glycolysis is in the cytoplasm. TCA Cycle is in the mitochondrial matrix. Electron chain transport is in the inner membrane of the mitochondria.
How many ATP are invested during Glycolysis? What is the return?
2 ATP invested, 4 ATP and 2 NADH (which each lead to 2 ATP) produced in return. A net gain of 6 ATP.
How many ATP are produced during pyruvate decarboxylation?
6 ATP
How many ATP are produced during the Citric Acid Cycle?
24 ATP.
6 NADH x 3ATP each = 18
2 FADH2 x 2ATP each = 4
2 GTP x 1 ATP each = 2
What anaerobic options are there for producing ATP? What is the net production of ATP?
Alcohol Fermentation and Lactic Acid Fermentation. The net ATP production is 2. In the absence of oxygen, the cell cannot go thru with electron transport chain and the TCA Cycle. Therefore, the only production of ATP comes from glycolysis.
What is the metabolic pathway of carbohydrates?
- carbohydrates
- hydrolysis to glucose
- PGAL
- pyruvate
- acetyl-CoA
- TCA Cycle
What is the metabolic pathway of proteins?
- hydrolysis to amino acids
- deamination to alpha-keto acids (goes to pyruvate and/or acetyl-CoA)
2’. transamination leads to keto acids (goes to TCA cycle or acetyl-CoA)
What is the metabolic pathway of fats?
- hydrolysis to
A. glycerol: goes to PGAL and continues on carbohydrate pathway
B. fatty acids: beta-oxidation to acetyl-CoA, then joins TCA cycle
Compare prokaryotic vs. eukaryotic cells.
Prokaryotes: no membrane bound organelles (no nucleus, ER, mitochondria, etc.), they have plasmids, can be spherical or have a flagellum, have smaller ribosomes, unicellular organism, no cell specification
Eukaryotes: has nucleus and EMS, nucleus and nucleolus, can be multi- or uni-cellular organisms, cells can specify
What is the difference between vesicles and vacuoles?
They are equivalent, but vacuoles are larger and tend to be found in plant cells.
What are chloroplasts?
They are solar power plants. They contain their own DNA, much like mitochondria, and are the power plants for photosynthesis. They contain chlorophyl and create energy using sunlight, CO2 and water.
What are the three components of the cytoskeleton?
- microfilaments: made of actin, used in muscles,
- intermediate filaments
- microtubules: made of tubulin proteins, hollow, provide big roads for transport, help separate chromosomes during mitosis and meiosis, structural basis for cilia and flagella
What is the stomach primarily a site for?
Digestion, not absorption.
What are the three sections of the small intestine?
duodenum, jejunum, and ileum.
Where does most digestion occur in the small intestine?
most Digestion in Duodenum.
What is the function of chewing?
Increase surface area of food so that it is more easily and readily digestible.
Where does most of the absorption of digestion occur?
In the jejunum and ileum.