Medication

Question 1

Antibiotic which is L4, toxic, and shouldn’t be used for trivial infections

Answer 1

Chloramphenicol

Question 2

RID

Answer 2

Relative infant dose, %
Should be less than 10%

Question 3

Oral bioavailability

Answer 3

How much of the medicine is actually absorbed by the baby from drinking the milk. Usually for injections the oral bioavailability is low.

Question 4

Milk/plasma ratio (m/p)

Answer 4

Should be less than 1

Question 5

Pka in drugs Should be

Answer 5

Low

Question 6

All medication properties:

Answer 6

1. High molecular weight (>800 Dalton)
2. High protein binding (> 90%)
3. Low lipid solubility
4. Short half life
5. Low oral bioavailability
6. Relative infant dose < 10%
7. Milk/plasma <1
8. Low pH and pka

Question 7

Usually how much of the maternal dose finds it’s way to breast milk

Answer 7

<1%

Question 8

Radioactive iodine should be avoided

Answer 8

I 131
I 125
I 123

Question 9

Preterm infant is more susceptible to drugs

Question 10

Methadone

Answer 10

For opioid dependence

Question 11

Metoclopramide (reglan)

Answer 11

Galactagogue
Off label

Question 12

Domperidone (motilium)

Answer 12

Galactagogue
Not approved in USA

Question 13

Bromocriptine

Answer 13

Stops milk production

Question 14

Cyclophosphamide

Answer 14

For lupus
No BF, toxic

Question 15

Nifedipine

Answer 15

Calcium channel blocker to treat vasospasms
Turns milk green
Green rhymes with nifedipine

Question 16

Varenicline

Answer 16

L4
For quit smoking
Avoid

Question 17

Sertraline (Zoloft)

Answer 17

For depression ssri
Safe

Question 18

Statins

Answer 18

Contraindication for bf

Question 19

L1

Answer 19

Safe, lots of studies

Question 20

L2

Answer 20

Minimal studies but safe

Question 21

L3

Answer 21

No studies but probably safe, by expert opinion

Question 22

L4

Answer 22

Possibly dangerous

Question 23

L5

Answer 23

Documented Risk