Mem and Emo (4) Flashcards
(23 cards)
What is Memory extinction?
New learning of a CS results in suppression of the original CS-US memory
Why does memory extinction occur?
as new memory is inhibitory
What does Memory reconsolidation allow?
allows memories to be strengthened, weakened and updated in content
What time period does memory reconsolidation occur in?
when information is impaired shortly after learning
What is memory reconsolidation?
previously-consolidated memories can be made accessed again through reactivation of the memory trace
2 factors that can affect reconsolidation of memories?
Intensity of training of memory trace
Age of memory trace
2 Mechanisms for reconsolidation?
Deconsolidation followed by reconsolidation
What does deconsolidation involve?
Protein degradation
What does reconsolidation involve?
Synaptic plasticity
What does the PKM molecule do?
Memory maintenance molecule
What is the special characteristic of the PKM molecule?
Once it is activated, it stays active as there is no regulatory domain to inactivate it.
What is the activation of PKM dependent on?
Plasticity inducing Synaptic activity, ERK/MAPK signalling pathway
What is PKM’s function?
Maintains plasticity at individual synapses
In fear extinction what neural connections must be made to the amygdala to reduce the fear response?
From the infralimbic vmPFC, inhibitory connections are made
What neural connections are made from the hippocampus to increase fear response?
Made to the infralimbic vmPFC, to inhibit its activity on the amygdala.
What protein is selectively required for reconsolidation?
Zif268
What is second order conditioning?
New information is added on as a separable memory to the original memory.
What is stage one of second order conditioning?
Normal classical conditioning.
What is stage 2 of second order conditioning?
Associate a new stimulus with the original CS
What is the first form of which a new stimulus can be associated with an original CS in second order conditioning?
Original memory is updated to include and integrate the new stimulus, as if the new one was always part of the CS
What is the second form of which a new stimulus can be associated with an original CS in second order conditioning?
The new stimulus is simply linked, it remains a separate memory, but is associated with the first memory
Gene expression in the hippocampus is normally associated with?
New learning consolidation
Gene expression in the amygdala is normally associated with?
Reconsolidation
