Menopause Flashcards

(86 cards)

1
Q

What are the most common difficulties menopausal women report at work?

A
  1. Poor concentration
  2. Tiredness
  3. Poor memory
  4. Feeling low
  5. Lowered confidence
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2
Q

Barriers to ethnic minority women seeking help with their menopause:

A
  1. Social stigma
  2. Menopause as a symbol of loss of fertility/femininity
  3. Lack of knowledge/health literacy
  4. Expectation not to complain/to cope
  5. Do not identify with narrative because education resources so no show ethnic minority women
  6. Language barriers
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3
Q

What is the mean age of menopause of women of African/Caribbean descent?

A

49.6

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4
Q

How may menopause differ in women of African and Caribbean descent?

A
  1. Longer duration of menopause transition.
  2. Highest prevalence and longest duration of vasomotor symptoms + more severe
  3. More likely to experience shorter sleep duration, more frequent awakenings and less efficient sleep.
  4. Smaller decline in sexual function and report a greater importance of sex
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5
Q

How may menopause differ in SE Asian women?

A
  1. May not complain of severe vasomotor symptoms
  2. May report a lower importance of sex and suffer more from low libido and sexual pain
  3. May suffer more from forgetfulness, joint and muscle pains.
  4. Have lower BMD but still have a lower risk of osteoporotic fractures than Caucasian women
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6
Q

What is the average age for Indian women (living in India) and Pakistani women?

A

Indian women (living in India) - 46.7
Pakistani women - 47.2

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7
Q

How may menopause differ in South Asian women?

A
  1. POI needs to be carefully considered in this population - women may have children earlier and their family complete by their mid-30s - they may not be worried about POI and they may not seek medical help which can then have implications for midlife health e.g. CVD, dementia, osteo etc.
  2. Indian women may complain more of vulval and uro-gynaecological symptoms
  3. There is a higher incidence of CVD risk factors during menopause transition such as metabolic syndrome, insulin
    resistance & diabetes, central obesity and hypertension
  4. Discussions about sexual health can be quite challenging and MH is not really talked about in these communities
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8
Q

How may HIV impact upon menopause?

A
  1. HIV is associated with an elevated risk of osteoporosis and cardiovascular disease, both of which are particularly increased among postmenopausal women
  2. Women with HIV 45-60 report high levels of menopausal symptoms
  3. Menopausal symptoms are associated with decreased adherence to ART
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9
Q

Key management points in those with HIV at menopause:

A
  1. Annual assessment of menopausal Sx in those >45
  2. As with women without HIV, bloods not routinely indicated over the age of 45 with Sx
  3. Use of transdermal preparations preferred due to lower risk of GI S/es and VTE
  4. There may be drug interaction between systemic HRT and some ART regimes - use drug checker
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10
Q

Which symptom is particularly more prominent following a surgical menopause?

A

Loss of libido

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11
Q

What may be the consequences of a surgical menopause?

A
  • More severe consequences,
    including increased rates of overall mortality, CHD, stroke, cognitive impairment, osteoporosis and sexual dysfunction
  • Evidence to suggest that the cardiovascular risk of
    surgical menopause may be greater than a premature natural menopause.
  • Post-menopausal ovaries play a role in androgen production, theorising that a surgical menopause can impact libido more significantly compared to natural menopause
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12
Q

All women aged under what age should receive HRT until natural age of menopause following a surgical menopause?

A

Women under 45 years old

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13
Q

How should HRT in women with a subtotal hysterectomy be managed?

A

Should have an initial progesterone challenge - two cycles of sequential HRT - if no bleeding occurs, or pathology reports confirm no remaining endometrium then they can be managed on oestrogen-only HRT. Otherwise, long term they will require ccHRT

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14
Q

How should HRT in BRCA carriers be managed following a surgical menopause?

A

Swap to non-hormonal methods at age 50/51yrs

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15
Q

In whom may tibolone be particularly helpful?

A

Those with low libido, due to some androgenic activity
May also be useful in women whom have endometriosis, who have had a hysterectomy/BSO, but whom may have some endometrial deposits remaining

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16
Q

What is the BMS consensus status on breast cancer risk in women using HRT <50?

A

Women aged <50 years using HRT do not have an increased risk of breast cancer

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17
Q

How should the HRT of women with endometriosis be managed following a surgical menopause?

A
  • ccHRT is advised in women who
    have widespread endometriosis to reduce the risk of stimulation/malignant transformation of deposits
  • Changing to estrogen-only at a later date due to a better safety profile can be considered but must
    be balanced with the risk of reactivating endometriosis and potential malignant transformation
  • HRT should be reviewed and suspended if symptoms recur.
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18
Q

How does age effect oestrogen dosing in HRT?

A

Younger women may require higher oestrogen doses to control Sx

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19
Q

Tips for discussing weight and nutrition with perimenopausal women:

A
  • Ask women how they feel about their diet and lifestyle. Don’t go straight in if they aren’t ready or happy to discuss the issue
  • Use a food and activity diary
  • Agree two or three changes at a time
  • Discuss strength exercise as part of a weight management regime. Regular, consistent weight resistance exercise is the most efficient method for increasing muscle mass and metabolic rate
    and changing body shape
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20
Q

How can you practically start a conversation about weight and nutrition?

A

Ask a patient to rate how healthy they feel their diet and lifestyle is out of 10. If they respond with a
figure less than 10, ask them what they’d need to do to achieve 10/10. Their answer will give you a very good indication of where they sit with knowledge and beliefs about healthy living

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21
Q

On average, how much weight does a woman gain during the menopause transition?

A

1.5kg year, resulting in a 10kg weight gain by the time menopause is reached

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22
Q

How does body fat change during the menopause?

A

Weight accumulates around the abdomen and upper body. As oestrogen levels reduce, visceral fat increases from 5-8% total body weight to 10-15% total body weight. Concurrently, metabolic rate slows as lean muscle mass
reduces.

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23
Q

How much calcium does a woman require?

A

Satisfactory bone density score? 700mg
Osteopenia/osteoporosis? 1200mg

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24
Q

How often should women established on HRT be reviewed?

A

Annually

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25
When may women not using hormonal methods of contraception stop using contraception?
If >50, after 1 year of amenorrhoea If <50, after 2 years of amenorrhoea
26
What are the major risk factors for endometrial cancer?
1. BMI ≥ 40 2. Hereditary conditions e.g. Lynch or Cowden syndrome 3. Estrogen-only HRT for >6/12 with a uterus 4. Tricycling HRT >12/12 5. Prolonged sHRT regimen - use for >5 years when started in women aged ≥ 45 6. 12 months or more of using shorter than recommended durations of progestogens in sHRT
27
What are the minor risk factors for endometrial cancer?
1. BMI 30-39 2. DM 3. PCOS 4. Unopposed estrogen for >3/12 but <612 5. Tricycling HRT for >6/12 but <12/12 6. >6/12, but <12/12 of using shorter than recommended durations of progestogens in sHRT 7. When the proportion progestogen to the estrogen dose for >12/12 (including expired 52 mg LNG-IUD
28
What are the minimum number of days of progestogen in sequential HRT?
MPA and NET - 10 days Micronised progestogen - 12 days
29
When should you move a patient from sequential to continuous combined HRT?
After 5 years, or by age 54 (whichever is soonest)
30
What is the first-line response to unscheduled bleeding, in absence of RFs for Endo Ca?
If a) unscheduled bleeding within 6/12 of starting HRT b) unscheduled bleeding persisting 3/12 after a HRT dose/prep change ...offer adjustments in progestogen/HRT prep for 6/12 total
31
After 6/12 of adjustments in progestogen/HRT prep, what should be offered?
Options: - Urgent USS (w/in 6 weeks) - Weaning off HRT - Consideration of non-hormonal alternatives
32
If patient transitions off HRT, how long do they have to stop bleeding until investigations required?
4 weeks
33
When should urgent TVUS (6 week) be offered irrespective of duration/change in prep?
a) If bleeding is prolonged/heavy b) There are 2 minor RFs for Endo Ca
34
When should a cancer pathway USS be offered?
One major or three minor RFs for Endo Ca
35
What are the endometrial cut-offs with different HRT regimes?
ccHRT
36
What should be done if ET increased on USS?
Biopsy --> if normal, change progestogens and can reassure for 3/12 If hysteroscopy and biopsy normal --> can reassure for 6/12
37
What proportion of women experiences unscheduled bleeding?
ccHRT - 41% sHRT - 38%
38
Ultra-low dose oestrogen doses:
Oestrogel 1/2 pump Sandrena 0.25mg Lenzetto 1 spray Patch 12.5microg Oral estradiol 0.5mg
39
Low dose oestrogen doses:
Oestrogel 1 pump Sandrena 0.5mg Lenzetto 2 sprays Patch 25microg Oral estradiol 1mg
40
Standard dose oestrogen doses:
Oestrogel 2 pumps Sandrena 1mg Lenzetto 3 sprays Patch 50microg Oral estradiol 2mg
41
Moderate dose oestrogen doses:
Oestrogel 3 pumps Sandrena 1.5-2mg Lenzetto N/A Patch 75microg Oral estradiol 3mg
42
High dose oestrogen doses:
Oestrogel 4 pumps Sandrena 3mg Lenzetto N/A Patch 100microg Oral estradiol 4mg
43
Up to what dose oestrogen can tibolone be used for endometrial protection?
Standard dose oestrogen
44
Within what distance of the fundus should the IUS be placed?
Within 2cm
45
Progestogen dose for ultra and low dose oestrogen regimes?
Micronised - cHRT 100mg - sHRT 200mg MPA - cHRT 2.5mg - sHRT 10mg NET - cHRT 5mg - sHRT 5mg
46
Progestogen dose for standard dose oestrogen regimes?
Micronised - cHRT 100mg - sHRT 200mg MPA - cHRT 2.5-5.mg - sHRT 10mg NET - cHRT 5mg - sHRT 5mg
47
Progestogen dose for moderate dose oestrogen regimes?
Micronised - cHRT 100mg - sHRT 200mg MPA - cHRT 5mg - sHRT 10mg NET - cHRT 5mg - sHRT 5mg
48
Progestogen dose for high dose oestrogen regimes?
Micronised - cHRT 200mg - sHRT 300mg MPA - cHRT 10mg - sHRT 20mg NET - cHRT 5mg - sHRT 5mg
49
What is the post-test probability of cancer with a positive pipelle biopsy?
81.7%
50
What is the post-test probability of cancer with a negative pipelle biopsy?
0.9%
51
What is the failure rate of pipelle biopsy in a post-menopausal woman?
12%
52
What is the inadequate rate of pipelle biopsy in a post-menopausal woman?
22%
53
What is the failure rate of hysteroscopy in a post-menopausal woman?
3.4%
54
What is the post-test probability of cancer with a positive hysteroscopy?
71.8%
55
What is the post-test probability of cancer with a negative hysteroscopy?
0.6%
56
In which ovarian cancers are HRT not contraindicated?
Epithelial ovarian cancers
57
Which ovarian cancers can express oestrogen receptors?
High grade serous and endometroid ovarian tumours Offer non-HRT options first, however, limited RCT evidence does not suggest increased risk of disease recurrence with systemic HRT
58
Can HRT be offered for low grade serous ovarian cancer?
FIGO I - offer non-hormonal options first, but HRT not contraindicated FIGO II-IV - not recommended as the disease is hormone sensitive and there is an advantage to oestrogen-suppressing treatment
59
Can HRT be offered following treatment for borderline ovarian tumours?
Yes
60
Can HRT be offered following treatment for germ cell ovarian tumours?
Yes
61
Can HRT be offered for granulosa cell tumours?
Limited evidence does not demonstrate harm in relation to a Stage I, however, these tumours are hormone-sensitive and women should be counselled regarding the risks
62
Can HRT be offered after vaginal and cervical cancer?
Yes - not hormone dependant
63
What are the HRT options for women whom have a uterus, but have had pelvic radiotherapy?
Continuous combined estrogen-progestogen HRT or Tibolone (due to functional endometrium that may remain after radiotherapy)
64
Can HRT be used for uterine leiomyosarcoma and endometrial stromal sarcoma?
Avoid (hormone sensitive), try everything else
65
By what degree are hot flushes reduced by oxybutynin?
50-77% reduction
66
In whom would you not use oxybutynin?
Frail, elderly population
67
Whom should have a bine density assessment?
Premenopausal women with treatment-induced menopause or women on aromatase inhibitors
68
What is the average age of early peri-menopause?
47
69
What is the average age of late peri-menopause?
49
70
What proportion of women report disabling menopausal symptoms?
25%
71
What proportion of women experience symptoms in the menopause?
80-90%
72
What is the female dose of testosterone?
5mg/day
73
What proportion of postmenopausal women experience genitourinary symptoms?
50%
74
What is the difference between 'body-identical' and 'bioidentical hormones'?
Body-identical HRT is regulated and prescribed by healthcare professionals, while bioidentical HRT is typically compounded and unregulated
75
What options are available for vaginal oestrogen?
Vagifem tablets (estradiol) Ovestin or Gynest creams (estriol)
76
When is the risk of DVT/PE greatest with HRT?
1st 12 months Remember, no increase in VTE with transdermal preparations
77
What do Evorel Conti patches contain?
Estradiol + NET
78
What do Femseven Conti patches contain?
Estradiol + LNG
79
What do Evorel Sequi patches contain?
Estradiol + NET
80
Which patches contain only oestrogen?
Evorel Estradot Estraderm Femseven mono
81
What schedule drug is gabapentin and pregabalin?
Schedule 2
82
What is the only (easily avilable) licensed non-hormonal medication for HRT?
Clonidine Fezolinetant is now also licensed
83
What proportion of patients experience sleep disturbance using clonidine?
50%
84
Which SSRIs CAN'T be used with tamoxifen?
Paroxetine Fluoxetine Sertraline (i.e. use citalopram)
85
Which SSRI brings about the greatest reduction in vasomotor Sx?
Paroxetine - maximal benefit at 10mg (lower dose)
86
What proportion of ovulation is inhibited by sequential HRT?
Only 40%