Menstrual Disorders Flashcards

(53 cards)

1
Q

When does the menstrual cycle begin and end?

A

From the first day of a woman’s period until the day before her next period

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2
Q

What is considered a normal amount of period blood loss?

A

less than 80ml over 7 days (16tsp)

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3
Q

What is the average period blood loss?

A

30-40ml (6-8 tsp)

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4
Q

What is the average period duration?

A

2-7 days

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5
Q

How long does a menstrual cycle last?

A

28 days (average 24-35 days)

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6
Q

When does menarche occur?

A

10-16 years old (average 12)

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7
Q

At what age does menopause occur?

A

50-55

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8
Q

What are the different types of menstrual disturbance?

A

disturbance of menstrual frequency - infrequent or frequent
irregular menstrual bleeding - absent or irregular
abnormal duration of flow - prolonged or shortened
abnormal menstrual volume - heavy or light

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9
Q

What are the criteria for a diagnosis of heavy menstrual bleeding?

A

Bleeding >80ml over 7 days, regular cycle
AND/OR
The need to change menstrual products every one to two hours
AND/OR
Passage of clots greater than 2.5cm
AND/OR
Bleeding through clothes
AND/OR
‘Very heavy’ periods as reported by the woman/affecting quality of life

Can occur alone or in combination with symptoms like dysmenorrhoea

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10
Q

Which uterine and ovarian pathologies can cause heavy menstrual bleeding?

A
Uterine fibroids (HMB/dysmenorrhoea, pelvic pain)
Endometrial polyps (HMB/intermenstrual bleeding)
Enometriosis and adenomyosis (HMB/dysmenorrhoea, dyspareunia, pelvic pain, difficulty conceiving)
Pelvic inflammatory disease and pelvic infection (for example chlamydia - may also present with vaginal discharge, pelvic pain, intermenstrual and postcoital bleeding, and fever)
Endometrial hyperplasia or carcinoma (postcoital bleeding, intermenstrual bleeding, pelvic pain)
Polycystic ovary syndrome (causes anovulatory menorrhagia and irregular bleeding)
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11
Q

Which systemic diseases and disorders can cause heavy menstrual bleeding?

A

Coagulation disorders (for example von Willebrand disease)
Hypothyroidism
Liver or renal disease

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12
Q

What are some iatrogenic causes of heavy menstrual bleeding?

A

Anticoagulant treatment
Herbal supplements (ginseng, ginkgo, soya) - these may cause menstrual irregularities by altering oestrogen levels or coagulation parameters
Intrauterine contraceptive device (Cu IUD)

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13
Q

What does PALM-COEIN stand for and what is it used for?

A

Causes of abnormal menstrual bleeding

Polyps
Adenomyosis
Leiomyoma/fibroid
Malignancy
Coagulopathy
Ovulatory dysfunction
Endometrium/hyperplasia
Iatrogenic
Not yet classified
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14
Q

What are fibroids?

A

Non cancerous growths made of muscle and fibrous tissue, also called myoma or lieoyoma

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15
Q

What are some of the symptoms of fibroids?

A

May be asymptomatic

Can cause:
HMB
Pelvic pain
Urinary symptoms
Pressure symptoms
Backache
Infertility
Miscarriage
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16
Q

How is a diagnosis of fibroids made?

A

Ultrasound

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17
Q

How is HMB +/- small fibroids treated?

A

COCP
POP
Mirena

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18
Q

How are large fibroids treated in a patient who wishes to preserve their fertility?

A

Fibroid embolisation

Myomectomy

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19
Q

How are submucosal fibroids treated?

A

Hysteroscopic fibroid resection

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20
Q

How do you treat fibroids in a patient who has declined or failed medical treatment and fertility preservation is not required?

A

Hysterectomy

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21
Q

What is endometriosis?

A

Endometrial tissue present outside the lining of the uterus. During menstruation this ectopic tissue behaves the same as endometrium and bleeds.

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22
Q

How many women in the UK are affected by endometriosis?

23
Q

What are some of the symptoms of endometriosis?

A

Painful menstrual cramps that get worse over time
Pain during and after sexual intercourse
Lower back pain
Painful bowel movements or urination
Abnormal bleeding or spotting between menstrual periods
Diarrhoea, nausea and blotting

24
Q

What are some possible sites for endometriosis?

A
Ovary
Pouch of Douglas
Bladder
Colon
Small intestine
Fallopian tube
Rectum
25
How many stages of endometriosis are there?
``` 4: Minimal Mild Moderate Severe ```
26
How is stage 1 (minimal) endometriosis characterised?
Small patches, surface lesions or inflammation on or around organs in the pelvic cavity
27
How is stage 2 (mild) endometriosis characterised?
More widespread than stage 1 and starting to infiltrate pelvic organs
28
How is stage 3 (moderate) endometriosis characterised?
Peritoneal (pelvic side walls) involvement or other structures, sometimes there is also scarring and adhesions
29
How is stage 4 (severe) endometriosis characterised?
Infiltrative and affecting many pelvic organs and ovaries, often with distortion of the anatomy and adhesions
30
How is endometriosis diagnosed?
Pelvic examination Ultrasound scan Diagnostic laparoscopy
31
How is endometriosis managed?
Analgesia / medical / surgical Medical: COCP, POP, Mirena IUS, depot provera, GnRH analogues Surgical: ablation, hysterectomy, endometrioma excision, pelvic clearance Surgical management may be required as part of fertility treatment
32
What is adenomyosis?
A condition where endometrium becomes embedded in myometrium
33
What are the symptoms of adenomyosis?
HMB | May have significant dysmenorrhoea
34
How is adenomyosis treated?
May respond to hormones partially | Definitive treatment is hysterectomy
35
What are endometrial polyps?
Overgrowth of endometrial lining can lead to formation of pedunculated structures called polyps which extend into myometrium, mostly benign
36
How is a diagnosis of endometrial polyps made?
Ultrasound or hysteroscopy
37
How are endometrial polyps treated?
Polypectomy
38
How should heavy menstrual bleeding be investigated?
``` Thorough history Pelvic examination (speculum, bimanual) Clotting profile Thyroid function Pelvic ultrasound scan Laparoscopy if endometriosis suspected ```
39
What is tranexamic acid and what does it do?
Antifibrinolytic - reduced blood loss by 60%
40
What is mefenamic acid and what does it do?
Prostaglandin inhibitor - reduces blood less by 30% and reduces pain
41
What are some of the medical treatments for heavy menstrual bleeding?
``` Tranexamic acid Mefenamic acid Hormonal contraception - COCP - levonorgestrel IUS - depo-provera - oral progestogens ```
42
What are some of the surgical treatments for heavy menstrual bleeding?
Endometrial ablation - first gen: under hysteroscopic vision - uses diathermy - second gen: thermal balloon, radiofrequency
43
What does a subtotal hysterectomy consist of?
Removal of the uterus, sparing the cervix
44
What does a total hysterectomy consist of?
Removal of the uterus and cervix
45
What does a total hysterectomy with bilateral salpingo-oopherectomy consist of?
Removal of the uterus and cervix, as well as both fallopian tubes and ovaries
46
What are the risks of a hysterectomy?
Infection DVT Bladder/bowel/vessel injury Altered bladder function Adhesions
47
What are the advantages and disadvantages of having a bilateral salpingo-oopherectomy alongside a hysterectomy?
Advantages: reduces risk of subsequent ovarian cancer Disadvantages: immediate menopause - recommended HRT til age 50
48
What are the risks of conserving the ovaries in a hysterectomy?
High risk of menopause in next 2 years due to compromised blood supply
49
What is oligomenorrhoea?
infrequent or abnormally light menstruation
50
What can cause oligo/amennorrhoea?
``` Life changes: stress, eating disorders/malnourishment, obesity, intense exercise Hormones: POP, Mirena, depo injection Primary ovarian insufficiency PCOS Hyperprolactinaemia Prolactinomas Thyroid disorders (hyperthyroid) Obstructions of the uterus, cervix and/or vagina ```
51
What is polycystic ovary syndrome?
Metabolic syndrome with diagnosis confirmed if 2 of 3 criteria are met: - no ovulation - high androgen levels - ovarian cysts
52
What are the differential diagnoses for PCOS?
Adrenal hyperplasia Hypothyroidism Hyperprolactinaemia/prolactinoma
53
How is PCOS treated?
Hormonal treatment - COCP, POP, Mirena IUS