Metabolism of Phospho- and Sphingolipids, Inositol Phosphates

Question 1

What is the main group of lipids

Answer 1

TAG, GPL

Question 2

Where are TAGs

Answer 2

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Question 3

What are Glycerphospholipids - structure, properties, where are they present

Answer 3

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Question 4

What are Sphingolipids - structure, properties

Answer 4

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Question 5

What are the membrane lipids

Answer 5

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Question 6

Give examples of a glycerophospholipid with specialised function

Answer 6

Dipalmitoylphosphatidyl Choline
Phosphatidylinositols
PAF - Platelet-activating factor

Question 7

What is the structure of Dipalmitoylphosphatidyl Choline (Dipalmitoyl Lecithin)

Answer 7

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Question 8

How is Diplamitoylphosphatidyl Choline synthesised

Answer 8

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Question 9

What is the function of Diplamitoylphosphatidyl Choline

Answer 9

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Question 10

What are the different Phosphatidylinositols

Answer 10

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Question 11

What is PIP2

Answer 11

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Question 12

What is PIP3

Answer 12

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Question 13

What is the function of PAF (Platelet-activating factor)

Answer 13

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Question 14

What is the structure of PAF (Platelet-activating factor)

Answer 14

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Question 15

What are the 3 examples of Glycosphingolipids

Answer 15

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Question 16

What do the carbohydrate residue of Glycosphingolipids participate in

Answer 16

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Question 17

Describe Cerebrosides

Answer 17

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Question 18

Describe Gaucher Disease (in relation to cerebrosides)

Answer 18

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Question 19

Where are galactocerebrosides predominantly found

Answer 19

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Question 20

Where are glucocerebrosides predominantly found

Answer 20

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Question 21

What are the 3 Sphingolipids with specialised function

Answer 21

Globosides
Sulfatides
Gangliosides

Question 22

What are Globosides

Answer 22

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Question 23

What are Sulfatides

Answer 23

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Question 24

What are Gangliosides - description, where are they present and what is their role

Answer 24

e.g GM2

Question 25

What are the sphingolipids involved in cell signalling

Answer 25

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Question 26

What is the role of Sphingosine-1-Phosphate SP1

Answer 26

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Question 27

What is the role of Ceramide-1-Phosphate C1P

Answer 27

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Question 28

What are the roles of sphingosine and ceramide in cell signalling

Answer 28

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Question 29

Where are ceramide derived from

Answer 29

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Question 30

Describe the relationship of sphingolipids with Blood Type Antigens

Answer 30

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Question 31

How are Glycophospholipids formed

Answer 31

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Question 32

What are the substrates for Glycerphospholipids synthesis

Answer 32

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Question 33

The substrates for Glycerphospholipids synthesis include FAs, what needs to happen to the FAs for the process to further

Answer 33

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Question 34

How does the body obtain Glycerol-3-Phosphate

Answer 34

HINT: Glycerol Kinase, Glycerol-3-P DH

Question 35

How does the degradation of glycerophospholipids occur and why is it possible

Answer 35

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Question 36

What are the different Phospholipases

Answer 36

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Question 37

All Sphingolipids are synthesised on the base of what?

Answer 37

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Question 38

1. What is the first step of Sphingolipid synthesis

Answer 38

HINT: 18-C formed

Question 39

2. What is the second step of Sphingolipid synthesis

Answer 39

HINT: amide linkage formed

Question 40

3. What is the third step of Sphingolipid synthesis

Answer 40

HINT: double bond added

Question 41

4. What is the fourth step of Sphingolipid synthesis

Answer 41

HINT: attachment of head group

Question 42

In what organelle does sphingolipids synthesise

Answer 42

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Question 43

What degrades gangliosides

Answer 43

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Question 44

What does pulmonary surfactant contain

Answer 44

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Question 45

What is the function of pulmonary surfactant

Answer 45

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Question 46

The deficiency of pulmonary surfactant in premature infants is known as - what is the treament

Answer 46

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Question 47

What are the 2 diseases that involve phospholipids PL and Sphingolipids SpL

Answer 47

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Question 48

What occurs in Multiple Sclerosis, in terms of PL and SpL

Answer 48

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Question 49

What is Sphingolipidosis

Answer 49

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Question 50

What enzyme is deficient in General Gangliosidosis

Answer 50

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Question 51

What enzyme is deficient in Tay-Sachs disease

Answer 51

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Question 52

What is Tay-Sachs disease and what are the symptoms

Answer 52

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Question 53

What enzyme is deficient in Gaucher's disease

Answer 53

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Question 54

What is Gaucher's disease and what are the symptoms

Answer 54

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Question 55

What enzyme is deficient in Niemann-Pick disease

Answer 55

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Question 56

What is Niemann-Pick disease and what are the symptoms

Answer 56

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Question 57

What enzyme is deficient in Fabry's disease

Answer 57

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