Methylprednisolone Sodium Succinate

Question 1

METHYLPREDNISOLONE SODIUM SUCCINATE (SOLUMEDROL)

Pharmacology & Actions

Answer 1

• Potent synthetic steroid that inhibits many substances that cause inflammatory response
• Controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level

Question 2

METHYLPREDNISOLONE SODIUM SUCCINATE (SOLUMEDROL)
Indications

Answer 2

• Acute bronchospastic disease (asthma or COPD)
• Adrenal insufficiency

Question 3

METHYLPREDNISOLONE SODIUM SUCCINATE (SOLUMEDROL)
Absolute Contraindications

Answer 3

• Traumatic brain injury (high doses)
• Methylprednisolone sodium succinate allergy

Question 4

METHYLPREDNISOLONE SODIUM SUCCINATE (SOLUMEDROL)
Precautions & Side Effects

Answer 4

• None

Question 5

METHYLPREDNISOLONE SODIUM SUCCINATE (SOLUMEDROL)
Administration

Answer 5

• IV
• Onset: 1-6 hours
• Peak Effect: 8 hours
• Duration: 18-36 hours