MHC

Question 1

What is component of MHC 1?

Answer 1

All nucleated cells

Question 2

What is component of MHC 2?

Answer 2

APC - dendritic cell, b cell + macrophages

Question 3

What is CD4+?

Answer 3

HELPER CELLS -> MHC 2

Question 4

What is CD8+?

Answer 4

CYTOTOXIC -> MHC 1

Question 5

how much alpha + beta in MHC 1?

Answer 5

3 alpha + 1 beta

Question 6

how much alpha + beta in MHC 2?

Answer 6

2 alpha + 2 beta

Question 7

how much Cytoplasmic tail in transmembrane region in MHC 1?

Answer 7

1

Question 8

how much Cytoplasmic tail in transmembrane region in MHC 2?

Answer 8

2

Question 9

Where is the peptide binding cleft/variable region in MHC 1?

Answer 9

between alpha 1 + 2

Question 10

Where is the peptide binding cleft/ variable region in MHC 2?

Answer 10

between alpha + beta

Question 11

What is cytoplasmic tail in transmembrane region?

Answer 11

for signal transduction

Question 12

is alpha or beta needed for signal transduction in MHC 1?

Answer 12

alpha

Question 13

Does MHC 1 go through membrane?

Answer 13

yes its transmembrane.

Question 14

Which alpha in MHC 1 bind to CD8?

Answer 14

alpha 3

Question 15

At the peptide binding cleft of MHC 1 - how many amino acids does it bind to?

Answer 15

8-10 amino acids

Question 16

What beta is in MHC 1?

Answer 16

BETA 2 MICROGLOBULIN

Question 17

Is beta necessary for MHC 1?

Answer 17

Without it we can’t make MHC 1

Question 18

How does MHC 1 get expressed?

Answer 18

Virus enter –> phagosome –> ubiquinated –> peptide –> enter via TAP to ER –> MHC 1 go through er to golgi to vesicle –> MHC 1 go out.

Question 19

What is HLA?

Answer 19

same as MHC

Question 20

Where is binding cleft in MHC2?

Answer 20

alpha 1 + beta 1

Question 21

Where is the conservative in MHC2?

Answer 21

alpha 2 + beta 2

Question 22

At the peptide binding cleft of MHC 2 - how many amino acids does it bind to?

Answer 22

13-25 amino acids

Question 23

Which beta in MHC 2 bind to CD4?

Answer 23

beta 2

Question 24

How many locis encode for MHC 2?

Answer 24

5

Question 25

How does MHC 2 get expressed?

Answer 25

antigen --> endolysosome --> ER --> MHC 2 + invarient chain --> golgi --> vesicle --> CLIP --> break invarient --> HLA --> break clip --> MHC 2

Question 26

How many peptides bind at once in MHC?

Answer 26

1

Question 27

What does MHC require of cells?

Answer 27

T

Question 28

What increases level of MHC?

Answer 28

CYTOKINES

Question 29

Peptides from ___ associate with MHC I

Answer 29

cytosol

Question 30

Peptides from ___ associate with MHC 2

Answer 30

vesicles

Question 31

HLAs in MHC 1:

Answer 31

HLA- a/b/c

Question 32

HLAs in MHC 2:

Answer 32

HLA- D p/q/r

Question 33

which MHC has endogenous antigens and which has exogenous antigens?

Answer 33

MHC 1: endogenous | 2: exogenous