MHC and transplantation Flashcards
What method was used to reveal blood group substance in cell membranes?
immunofluorescent staining
Which isoagglutinins naturally occur in normal individuals?
anti-A and anti-B
Where are the proteins encoded by MHC expressed?
cell surface
how many MHC molecules are on the average mammalian cell?
50,000-100,000
What does HLA class I region encode?
HLA-A, B and C (‘classical’ antigens)
what does class II region encode?
HLA-DR, DQ, DP antigens
What does class III region encode?
HSP70, TNF, C4A, C4B, C2, BF, CYP21
What does HLA stand for?
human leucocyte antigens
Which class of HLA antigens are found in all nucleated cells?
class I
Where are class Ii antigens primarily expressed?
B lymphocytes (but can be induced on T lymphocytes and other cells)
How would you describe the genera structure of HLA?
domain like structure
What is the inheritance of HLA?
Mendelian inheritance
What does codominant expression mean?
everything you inherit, you express
How is allelic variation maintained at population level?
due to survival advantage
Which type of recognition is the most common in transplantation?
indirect recognition
