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The Cardiovascular System > MI and Ischaemic Heart Disease > Flashcards

MI and Ischaemic Heart Disease Flashcards

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1
Q

What is chronic stable angina?

A

Demand led ischaemia of the heart muscle due to a fixed stenosis

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2
Q

What is the recommendation for patients who have an angina attack and have stable angina?

A

Stop, sit and use GTN spray

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3
Q

When may angina commonly be felt?

A
  • After a meal
  • In cold air
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4
Q

Where does pain for angina commonly radiate?

A
  • Jaw
  • Back
  • Epigastrium
  • Left (and right) arm
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5
Q

What type of pain is felt with angina?

A

Heavy crushing pain with tightness

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6
Q

What are the two types of acute MI?

A
  1. STEMI
  2. NON-STEMI (NSTEMI)
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7
Q

Why does acute cornonary syndrome occur?

A

Development of an atheromatous plaque that develops a thrombosis and ruptures

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8
Q

Which steps lead to thrombosis occuring?

A
  • Normal
  • Fatty streak
  • Atherosclerotic plaque
  • Fibrous plaque
  • Rupture/thrombosis
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9
Q

In what ways is chronic stable angina different to an acute coronary syndrome such as unstable angina?

A
  • It has a fixed stenosis (not comple occulsion)
  • Demand led ischaemia (not supply led)
  • Predictable
  • Safe
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10
Q

What are the three sub-stages of thrombosis formation?

A
  1. Initiation
  2. Adhesion
  3. Activation
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11
Q

Describe the initiation stage of thrombosis formation

A

There is vascular damage exposing the sub-endothelium, collagen and von Willebrand factor

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12
Q

Describe the adhesion stage of thrombosis formation

A

Platelets recruit to the area and bind to the exposed collagen and von Willebrand factor forming a monolayer

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13
Q

Describe the activation stage of thrombosis formation

A
  • Platelets become activated after adhesion and change shape from discs to star-like shapes
  • Platelets release ADP and thromboxane A2 (generated by cyclooxygenase)
  • ADP bind to receptors on circulating platelets allowing more activation to occur
  • Activated platelets express adhesion sites for leukocytes (P-selectin and CD40 ligand)
  • These processes contribute to the platelet cascade which causes acceleration of platelets activation and coagulation
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14
Q

What is the consequence of intraluminal coagulation?

A

Vascular blockage

Hence MI, stroke and death are all possible

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15
Q

What are key synptoms of MI?

A
  • Severe crushing (10/10) pain not relieved by GTN and lasting a long time
  • Pain occurs at rest
  • Pain radiates to jaw, left (and right) arm, back and epigastric region
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16
Q

For a MI, where will the changes be seen on an ECG?

A
  • ST elevation
  • T wave inversion
  • Q waves
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17
Q

How is a STEMI seen on an ECG?

A
  • >/= 1mm ST elevation in 2 adjacent limb leads
  • >/= 2mm ST elevation in at least 2 continous precordial leads
  • New onset bundle branch block
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18
Q

How does the ECG change after an MI?

A
  1. Initially an ST elevation is present (a few hours)
  2. Q wave formation and T wave inversion follow (within a day)
  3. Finally, Q waves are present with or without T waves
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19
Q

In an inferior MI, which limb leads will be affected?

A

II, III, aVF

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20
Q

In an aterior MI which limb leads can be affected?

A

V1-6

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21
Q

In an anteroseptal MI, which limb leads are affected?

A

V1-4

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22
Q

In an anterolateral MI, which limb leads are affected?

A

I, aVL, V1-6

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23
Q

Which two urine tests can help in the diagnosis of MI?

A
  1. Creatinine kinase
  2. Troponin C
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24
Q

At what time will creatinine kinase levels peak in the urine after MI and what does this signify?

A

Within 24 hours

Creatinine kinase found in muscle and brain cells

Suggests muscle damage

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25
What does the presence of troponin C in urine suggest?
Highly specific for cardiac muscle It is a good indicator for myocardial necrosis
26
How is a STEMI immediately treated?
Clopidogrel - 300mg Aspirin - 300mg
27
What is clopidogrel?
An inhibitor of ADP binding sites (P2Y12 receptor) which prevents activation of glycoprotein IIb/IIIa (fibrinogen receptors) on platelets
28
How does aspirin work?
Aspirin prevent cyclooxygenase (COX-1) activation in platelets This prevents production of thromboxane A2 (it also blocks COX in endothelial cells blocking production of anti-thrombotic prostaglandin I2 is inhibited - this is not useful)
29
What is thrombolysis?
A way of unblockign arteries by breaking down clots using thrombolytic drugs such as streptokinase
30
When should thrombolysis be administered?
1. Chest pain is suggestive of acute MI (more than 20 minutes and less than 12 hours) 2. ECG changes - acute ST elevation, new LBBB 3. No contraindications It is NOT administered if PCI will be available
31
What is the downside to thrombolysis?
It can lead to severe intracranial haemorrhage
32
What is primary angioplasty?
A procedure also termed percutaneous coronary intervention (PCI) or coronary angioplasty, which involves inserting a wire through the coronary artery and opening it up again by inserting a balloon
33
What type of pain relief is given for MI?
Analgesic - Diamorphine (IV)
34
What is the full list of treatment given to a patient with a STEMI?
* Analgesia - diamorphine (IV) * Antiemetic - IV * Aspirin - 300mg * Clopidogrel - 300mg * GTN - when BP \>90mmHg * Oxygen - if hypoxic * Primary angioplasty (PCI) * Thrombolysis - when angioplasty is not available within 90 minutes
35
Infarction of myocytes most likey causes which type of arrhythmia?
Ventricular fibrillation
36
What is the KILLIP classification?
A system used in individuals with acute MI taking into account examination and the development of heart failure in order to predict the risk of mortality
37
Describe stages 1 to 4 in the KILLIP classification
* I - No signs of heart failure * II - Crepitation \< 50% of lung fields * III - Crepitations \> 50% of lung fields * IV - Cardiogenic shock
38
How may an NSTEMI be diagnosed?
* ECG may be normal * Pain is present in normal areas - left/right arm, jaw, back and epiastrium * Troponin/creatinine kinase levels in urine
39
Troponin is a proetin exclusive to which cells?
Cardiac cells
40
Why is troponin a good test and relevant to MI?
When mycotyes undergo necrosis after MI, troponin is released and can be present in the urine
41
What are the three types of troponin?
Troponin C - binds to calcium and is identicle in heart and muscle cells Troponin I - in absence of calcium it binds to actin and inhibits actin-myosin ATPase induced contraction, it is specific to the heart Troponin T - links troponin complex to tropomyosin faciliating contraction, it is also specific to the heart
42
Which two out of the three troponin types have a higher likelihood of pointing towards MI?
TnT and TnI - they are specific to the heart muscle
43
Troponin may be detected in the urine in which other conditions?
* PE * Post arrhythmia * Renal failure * Hypertensive crisis
44
What is a class I MI?
Spontaneous MI related to ischaemia due to a primary coronary event such as plaque erosion and or rupture
45
What is a class 2 MI?
MI secondary to ischaemia due to imbalance of oxygen supply and demand from cornary spasm, embolism, anaemia, arrhythmias etc.
46
What is a class 3 MI?
Sudden unexpected cardiac death including cardiac arrest often with symptoms suggestive of ischaemia With new ST segment elevation, new LBBB, or pathological or angiographic evidence of fresh coronary thrombus
47
What is a class 4a MI?
MI associated with PCI
48
What is a class 4B MI?
MI associated with documented in-stent thrombosis
49
What is a class 5 MI?
MI associated with coronary artery bypass graft surgery
50
Which drugs can act as ADP antagonists?
* Ticegralor * Ticlopidine * Clopidogrel * Prasugrel
51
Which drugs can act as COX inhibitors?
Aspirin
52
Which drugs are phosphodiesterase inhibitors?
Dipyridamole
53
Whcih drugs are GP IIb/IIIa inhibitors?
* Tirofiban * Eptifibatide * Abciximab (block platelet aggregation)
54
What may be used to identify stenosis?
Coronary angiography
55
Describe coronary revascularisation
A balloon catheter can stretch out a vessel and push down the plaque to keep the vessel open or An intracoronary stent can be administered via balloon to keep the vessel open
56
What is a transient ischaemic attack (TIA)?
This occurs due to an unstable plaque The blockage will last only for a short time
57
Acute MI involves what extent of vessel occulusion?
Complete
58
What is ischaemic cardiomyopathy?
The negative effects of remodelling and scar tissue from a previous MI
59
Is angina a symptom?
No It is a clinical diagnosis
60
Does pain from angina last a long time?
No, usually a short period
61
What type of pain is angina?
Visceral pain Feels like squeezing, heaviness and is similar to a weight on the chest
62
Where does pain from angina often radiate?
* Arms * Back * Jaw * Teeth * Shoulder
63
How can anginal pain be brought on?
* Exertion * Stress * Cold wind * After meal
64
Which drug is commonly used to relieve anginal pain?
GTN spray
65
What is the differential diagnosis of chest pain?
* GI - acid reflux, peptic ulcer, oesophageal spasm, biliary colic * MSK - Hurts during movement, lasts longer, nerve root pain * Pericarditis - central and posture related * Pleuritic pain - exacerbated by breathing, sharp
66
Is it true that morphine can relieve the pain from an MI?
Not always The pain from an MI is very severe
67
What type of pain is felt with a PE in comparision to an MI?
Dull pain
68
How can angina be tested for?
Exercise testing - shows characteristic changes on ECG Perfusion scanning - can identify areas of the heart with decreased blood flow CT angiography - non invasive, but less precise than angiography when calcium is present Angiography - a sheath is instered into the artery (radial/femoral), x-ray contrast is injectedto outline arteries. This test is the gold standard
69
How can the risk factors be reduced for angina?
* Drugs - aspirin, B blockers, statins, ACEI * Lifestyle - smoking cessation and diet * Revascularisation - CABG, PCI
70
Which two veins may be targeted for coronary revascularisation?
1. The left internal thoracic artery 2. A great saphenous vein
71
Describe how the left thoracic artery can be used in coronary artery bypass grafts
The left thoracic artery is diverted to the left anterior descending branch of the left coronary artery, bypassing the occulusion
72
Describe how a great saphenous vein is used for coronary revascularisation
The vein is removed from a leg One end is attched to the aorta or one of the major branches The other end is attched to the obstructed artery immediately after the occulsion This will restore blood flow
73
What is cardioplegia?
The intentional cessation of cardiac activity This is often done for surgical purposes
74
For a STEMI what is the gold standard treatment?
PCI

The Cardiovascular System (24 decks)

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