MicroB Antimicrobials 1. Principal of Antimicrobials Flashcards
What is CONCENTRATION DEPENDENT KILLING?
The rate and extent of microorganism killing are dependent on the antimicrobial […]
- See …
- These antibiotics are given at high doses at less frequent intervals (e g once a day)
What is CONCENTRATION DEPENDENT KILLING?
The rate and extent of microorganism killing are dependent on the antimicrobial concentration
- See **peak concentration (Cmax /MIC **)(e g aminoglycosides)
- These antibiotics are given at high doses at less frequent intervals (e g once a day)
What is POST ANTIBIOTIC EFFECT (PAE)?
The suppression of microbial growth that persists after levels of antibiotic have fallen […] the MIC
- These drugs may demonstrate […] time and concentration dependent properties (e g carbapenems)
What is POST ANTIBIOTIC EFFECT (PAE)?
The suppression of microbial growth that persists after levels of antibiotic have fallen BELOW the MIC
- These drugs may demonstrate both time and concentration dependent properties (e g carbapenems)
Recovery from the PAE induced by the aminoglycoside tobramycin in E coli depends upon re-establishment of protein synthesis
Recovery from the ciprofloxacin induced PAE depends upon restoration of DNA synthesis
What is TIME DEPENDENT KILLING?
The rate and extent of microbe killing remain […] regardless of how high antimicrobial concentration is, provided it is above the MIC.
- See […]
- To maximize time dependent activity, these antibiotics need to be administered […] so that the antibiotic concentration is above the MIC for as long as possible (e g beta lactams)
What is TIME DEPENDENT KILLING?
The rate and extent of microbe killing remain unchanged regardless of how high antimicrobial concentration is, provided it is above the MIC.
- See period of time the concentration is above the MIC (T> MIC)
- To maximize time dependent activity, these antibiotics need to be administered regularly so that the antibiotic concentration is above the MIC for as long as possible (e g beta lactams)
