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(VIII)Sporing Anaerobic Gram Positive Rods (2) Clostridium Botulinum Flashcards

(2 cards)

1
Q

Characterize (3) : Clostridium botulinum

A

(1) Gram (+) rod
(2) Spores
(3) Obligate anaerobe

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2
Q

Clostridium Botulinum infection

Transmission: Contact with wound or food poisoning (canned food).

Virulence factor & Mechanism: […]

Clinical Presentation:
[…]
- Early signs: […]
- Severe conditions: […]

Treatment:
[…]

A

Clostridium Botulinum infection

Transmission: Contact with wound or food poisoning (canned food).

Virulence factor & Mechanism: Botulinum toxin: blocks Ach release at NMJ (flaccid paralysis)

Clinical Presentation:
Botulism (flaccid paralysis)
- Early signs: diplopia, dysphagia, ptosis, nausea, vomiting, usually no fever
- Severe conditions: paralysis of respiratory muscles (death!!)

Treatment:
Antiserum + ventilate

Note that there is
- infant botulism (constipation, dysphagia, muscle weakness “floppy baby”) and
- wound botulism (esp in IVDAs) (adult botulism symptoms - GIT symtomps + fever and elevation of white count) as well.

Adults usually ingest pre-formed toxin, infants usually ingest spores which then produces the toxins in the gut.

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