(XVI) Viruses (3)*HIV

Question 1

AIDS defined by

1. CD4+ T cell count below […]
2. 1 or more […]

Answer 1

AIDS defined by

1. CD4+ T cell count below 200/mm3 (200/ul)
2. 1 or more Opportunistic Infections/Malignancies

Question 2

Are HIV found in breastmilk?

[…]

Answer 2

Are HIV found in breastmilk?

YES! so positive mummies shouldnt breastfeed

Question 3

Attachment of HIV virus to CD4 is by […]

Answer 3

Attachment of HIV virus to CD4 is by gp120 (outer glycoprotein membrane)

Question 4

Briefly describe pathology of HIV’s infection on cellular level.

1. […]
2. […]
3. […]
4. […]

Answer 4

Briefly describe pathology of HIV’s infection on cellular level.

1. Fusion of HIV on cells expressing CD4 (attachment, entry, uncoating)
2. Viral DNA formed from RNA by reverse transcriptase and integrated into in host DNA by integrase (Reverse transcription, integration)
3. Synthesis of viral parts using new viral RNA and host cell machinery (synthesis)
4. New viral RNA and protein move to cell surface, formation of new HIV virus (assembly, protease action & release)

Question 5

Clinical diagnoses of HIV requries confirmation by a mandatory second test:

[…]

Answer 5

Clinical diagnoses of HIV requries confirmation by a mandatory second test:

***Western Blot (tests for viral proteins)
*
p24, gp41, gp120 bands