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Flashcards in Microbiology Deck (16):
1

Osteomyelitis

Inflammation of bone and medullary cavity, normally in one of the long bones

2

Contiguous vs haematogenous source

Contagious - coming directly or adjacent to eg. break, surgery or bite
Haematogenous - coming from blood stream

3

What is the most important pathogen in osteomyelitis?

Staph aureus

4

What are the main subtypes of osteomyelitis?

1) Open fracture
2) Diabetes/vascular insufficiency
3) Haematogeneous osteomyelitis
4) Vertebral osteomyelitis
5) Prosthetic joint infection

5

What is the 'Rule of 2's in diabetic insufficiency with osteomyelitis?

If the ulcer has been there for more than 2 months and is more than 2 cm in diameter then it is likely there will be osteomyelitis

6

What is the management for suspected osteomyelitis?

1) Examine, inflammatory markers probe to bone test
2) Radiography
3) Bone biopsy
4) Debridement and antimicrobials

7

What situations are the exception to waiting for biopsy before giving antibiotics?

Suspected sepsis or severe soft tissue involvement

8

In what groups of people does haematogenous osteomyelitis occur?

PWID (People who inject drugs) and children (large bone blood supply as still growing)

9

Which pathogens are most common in PWID osteomyelitis?

Staph and strep

10

What is the most common source for vertebral osteomyelitis, and what can they be associated with?

Haematogenous, can be associated with psoas abscess or epidural abscess

11

Pott's Disease

Skeletal TB when it is in the vertebrae

12

What are the risk factors for prosthetic joint osteomyelitis?

RA, diabetes, malnutrition and obesity

13

What is the most important pathogen in prosthetic osetomyeltits, and what is its treatment?

Staph epidermidis - Vancomycin

14

Septic arthritis

Inflammation of the joint space caused by infection

15

What is the investigations for septic arthritis?

Joint aspiration > Microscopy, C&S
Blood culture if pyrexial
Exclude crystals

16

Which pathogen causes tetanus?

Clostridium tetani (gram +ve strict anaerobic rod)