Microbiology Chapter 15 Flashcards Preview

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Flashcards in Microbiology Chapter 15 Deck (21):
1

Any molecule that stimulates an immune response

Antigen (Ag)

2

B Cell receptor is what kind of a molecule?

Immunoglobulin (Ig)

3

B cells receptors are secreted as what?

Antibodies (Ab = Ig)

4

What is never secreted?

T-Cell receptor (TCR)

5

List the Antigen Presenting Cells (APC)

Macrophages, B-Cells, and Dendritic Cells (Macrophage-like cell in tissue)

6

What are the functions of APC?

Process and present antigen in association with MHC II (cell surface protein on host cells). T-Cell receptor recognize antigen/MHC complex.

7

Thought to secrete interleukin; a cytokine which suppresses helper T-Cells

Regulatory B-Cell

8

Secreted protein that regulates other cells

Cytokine

9

Immunoglobulin classes

IgG, IgA, IgM, IgD, IgE

10

Based on the Fc (constant region) fragment

Isotopes

11

Most prevalent in tissue fluid and blood. Only one to cross Placenta.

IgG

12

Monomer or dimer (secretory IgA). Dimer - two Ig held together by a J chain. Secretory IgA is there for local immunity (salivary glands, intestine, nasal membrane, breast, lung, genitourinary tract. Provides protection for newborns.

IgA

13

Pentomer (five monomers). First to be synthesized during primary immune response. Associated with complement activation. Circulates in the blood

IgM

14

Monomer. Small amounts in the serum (rarely secreted). Receptor for antigen on B-cells is its only function.

IgD

15

Activates during allergies and parasite infections.Constant region binds to mast cells and basophils which release chemical mediators that aid inflammation.

IgE

16

Direct Involvement of T-Cells. Produce and react to cytokines. Activated simultaneously with B cell activation. Subset of T cells have unique CD receptors (CD4, CD8)

Cell-Mediated Immunity

17

Types of T-cells

Helper T-cells (TH) CD4+
Cytotoxic T cells (TC) CD8+

18

What helps T-cell bind to Ag on MHCII

CD4

19

Binds and lyses infected cells and cancer cells

Cytotoxic Cells

20

T-helped cell binds to Ag plus MHC II on antigen presenting cell.

TH cell Activation

21

T-cytotoxic cells binds to Ag plus MHC I on target cells (cells to be killed)

TC Activation