Midterm 3 (continue use after each quiz)

Question 1

What type of estrogen is common in menopause?

Answer 1

Estrone E1

Question 2

What type of estrogen is common in productive years?

Answer 2

Estradiol E2

Question 3

What type of estrogen is common in pregnancy?

Answer 3

Estratriol E3

Question 4

What is the synthetic steroidal estrogen?

Answer 4

Ethinyl Estradiol

Question 5

What is the synthetic non-steroidal estrogen?

Answer 5

Diethylstilbesterol

Question 6

What does combo progesterone and estrogen do for contraception?

Answer 6

decreases ovulation 100%

Question 7

What does progestin only do for contraception? (minipill)

Answer 7

decreases ovulation 50-80%

thickens mucus to slow sperm down

Question 8

What is monophasic, biphasic, triphasic for contraception?

Answer 8

Mono: constant dose of estrogen and progesterone
Bi: dose of one or both change one time
Tri: dose changes 2 times

Question 9

What does Tamoxifen do? What’s it also used to treat?

Answer 9

blocks estrogen actions in breast for breast cancer.

Also used for oral contraception

Question 10

What does Mifepristone do? When is it used?

Answer 10

Blocks progesterone and glucocorticoid receptors for oral contraception.
Morning after sex.

Question 11

What does Danazol do?

Side effect?

Answer 11

suppresses ovarian function oral contraception.

Masculinizing side effect

Question 12

What drug is ovulation inducing to promote pregnancy?

Answer 12

Clomiphene

Question 13

What drug is a primary treatment for gout? how does it work?

Answer 13

Allopurinol.

decreases synthesis of purines.

Question 14

What drugs can be used for anti inflammatory (steroids)? 3

Answer 14

Dexamethasone
Cortisone
Prednisone

Question 15

What two drugs are keratolytics?
How does it works?
2 uses?

Answer 15

Salicylic acid.
Benzoyl peroxide.
Removes the keratin layer to open glands.
Wart removers/Acne

Question 16

What 2 retinoid drugs are there?
What are they used for?
Side effects?
What are they derived from?

Answer 16

Tretinoin (topical)
Isotretinoin (systemic): major birth defects.
Acne.
Derived from Vit A.

Question 17

What drugs are Muscle relaxants? MOA (BCDD)

Answer 17

Baclofen (GABA B antagonist)
Carisoprodol (sedative in Soma)
Diazepam
Dantrolene (alters Ca++ trafficking)

Question 18

What two drugs are good antivirals for shingles and herpes? What do they work good on?
Which one is longer acting?

Answer 18

Acyclovir (best on HSV)
Famciclovir (best on VSV and HSV)
Famciclovir is longer acting.

Question 19

What are two DMARD (disease modifying anti-rheumatic drugs)?
MOA?
3 side effects?

Answer 19

Sulfasalazine.
Methotrexate.
Slow inflammation and bone damage in arthritis.
Hepatotoxic, Stomatitis, Immunosuppressed.

Question 20

What are non-drug treatments for acne?

Answer 20

UV-phototherapy

Question 21

What are 2 non-depolarizing neuromuscular blocking drugs?

MOA for both?

Answer 21

Tubocurarine, Acetylchoninerase
Tubo: depolarizing Nicotinic receptors.
Acet: blocks by overwhelming with ACh

Question 22

What does Dapson, Clindimycin, Erythromycin, Tetracyclin do for acne?

Answer 22

eliminates bacteria that’s causing it.

Question 23

What’s a depolarizing neuromuscular blocking agent? MOA?

What can make it irreversible?

Answer 23

Succinylcholine.
Succ: Blocks Nicotinic receptors by desensitizing.
Acetylcholinesterase inhibitor.

Question 24

What is foscarnet used for?
Why’s it good?
MOA?

Answer 24

Antiviral.
Less resistance problems.
Non-thymidine dependent.

Question 25

What is Pilocarpine for? How does it work? What type of drug is it?

Answer 25

Glaucoma. Increases outflow of aqueous humor by contracting ciliary muscle. Cholinomimetic.

Question 26

What is Timolol for? How does it work? What type of drug is it?

Answer 26

Glaucoma. decreases aqueous humor secretion for open angle glaucoma. Beta blocker.

Question 27

What type of Alpha-agonist is used to treat Glaucoma?

Answer 27

Epinephrine

Question 28

What is Lantanoprost used for? How does it work? What type of drug is it?

Answer 28

Glaucoma. increases outflow of aqueous humor. prostaglandin.

Question 29

What is acetazolamide used for? | How does it work?

Answer 29

Glaucoma. | Reduces aqueous humor secretion.

Question 30

What are the drugs for Glaucoma? LEPAT

Answer 30

``` Lantanoprost. Epinephrine. Pilocarpine. Acetazolamide. Timolol. ```

Question 31

What do anticholinergics (amphetamines) do to glaucoma?

Answer 31

Make it worse.

Question 32

What is Bevacizumab used for? | What type of drug is it?

Answer 32

Age-related Macular degeneration. | Monoclonal Ab drug.

Question 33

What are the drugs for Meniere disease (ear disease)? DMD PH

Answer 33

``` Diazepam Meclizine Dexamethasone Promethazine Hydrochlorothiazide. ```

Question 34

What is Diazepam used for?

Answer 34

Meniere disease of the ear

Question 35

What is Meclizine and Promethazine used for?What type of drug is it? What symptoms does it relieve?

Answer 35

Meniere disease of the ear. H1 blocker. Motion sickness relief.

Question 36

What is Dexamethasone used for? | How is it administered and how does it relieve symptoms?

Answer 36

Meniere disease of the ear. | Injected into ear, it reduces fluid.

Question 37

What is hydrochlorothiazide used for? | How does it work?

Answer 37

Meniere disease of the ear. | Regulates fluid volume and pressure in ear.

Question 38

What ear problem does Ceclafor/Clavulanate or Amoxicillin/ help with? What are the second level drugs to help with this disease?

Answer 38

Otitis media infections | Trimethoprim/Macrolides

Question 39

What's are 2 new treatment strategy drugs for cancer? | How does it work?

Answer 39

Imatinib. Erlotinib Imat: Tyrosine hydroxylase inhibitor. Erlo: blocks epidermal growth factor

Question 40

What's an alkylating agent drug for cancer? How does it work? What type of cancer does it treat?

Answer 40

Cyclophosphamide. Transfers alkyl groups to various cell constituents such as DNA. Brain cancer.

Question 41

What's a Nitrosourea drug for Cancer? | Whats good about it?

Answer 41

Procarbazine | Crosses BBB

Question 42

What's a platinum analog drug for cancer?

Answer 42

Cisplatin

Question 43

What's an antimetabolite drug for cancer? | How does it work?

Answer 43

Methyltrexate. | Interferes with proliferating DNA.

Question 44

What are 2 natural product chemotherapy drugs? | How does it work?

Answer 44

Vinblastine or Vincristine. | Inhibits tubulin polymerization.

Question 45

What's are 3 anti-tumor antibiotic drug for cancer? What cancer do they treat? MOA?

Answer 45

Anthracycline. doxorubicin/bleomycin breast cancer forms free radicals that bind DNA

Question 46

What is MOA of Fluorouracil as a cancer drug? | What does fluorocil treat?

Answer 46

Inhibits thymidine synthase and NDA synthase. | Colon cancer

Question 47

What drug treats Multiple myeloma?

Answer 47

Prednisone

Question 48

What are 3 types of H2 receptors blockers to use for GERD? one side effect. What are the 3 OTC's for GERD? What side effect for each one?

Answer 48

Cimetidine (headaches) Famotidine Ranitidine Mg (diarrhea) Bicarb (farts, acid rebound) Calcium carbonate (constipation)

Question 49

What are 3 types of proton pump inhibitors for GERD? | Side effects?

Answer 49

Omeprazole Lansoprazole Esomeprazoleq Side effects: Canker sores

Question 50

What to treat peptic ulcer disease with? 2 drugs...What is the second drug made of?

Answer 50

Milk of magnesia | Prevpac (lansoprazole, amoxicillin)

Question 51

What 2 drugs for constipation? How do they work?

Answer 51

Bisacodyl (smooth muscle stimulant) | Docusate (water retention in poop)

Question 52

What are 3 drugs for Diarrhea?

Answer 52

Loperamine (Imodium) Atropine (Anti-cholinergics) Bismuth

Question 53

What is the drug for Irritable Bowel syndrome, which symptom does it work for? MOA?

Answer 53

Linaclotide (constipation) | MOA: guanylate cyclase agonist

Question 54

What are 3 drugs for Inflammatory Bowel Disease?What types of drug are they?

Answer 54

Mesalamine (antiinflammatory) Corticosteroids (antiinflammatory) Metronidazole (antibiotic)