Midterm Flashcards
How would you work up someone with a primary immunodeficiency?
CBC w/ differential
Swab/sputum culture
Respiratory Panel
Blood, urine, CSF cultures
Your pt is a 4yo presenting with fever, lethargy, won’t eat, barely drinking for the past 2 days. No cough. Negative PMH. What do you suspect and how do you work it up?
Secondary Immune issue
CBC w/ differential
CMP (electrolytes)
Primary immunodeficiencies can be characterized by their defect:
(4 types)
Cellular immunity (T-cells)
Humoral immunity (B cells)
Phagocytes
Complement
Many primary immunodeficiencies are inherited these 2 ways
X linked
Autosomal recessive
Consider Primary immunodeficiency in children with SPUR:
Severe, Prolonged, Unusual, Recurrent infections
SCID(Severe combined immunodeficiency) and Wiskott-Aldrich(Aldrich syndrome) and DiGeorge are all caused by___ defects
T-cell
_____ is characterized by eczema and thrombocytopenia
Wiskott-Aldrich syndrome
_____ defects usually aren’t seen until after 6 mo due to remaining maternal immunoglobulins.
B-cell
Aggamaglobulinemia, CVID, Hyper IgM syndrome are all caused by:
B cell deficiency
T/F: immunizations are essential for kids with B cell deficiencies
False. Can’t make memory cells anyways
Most common cause of stridor in infants
Laryngomalacia
Most common cause of drug-induced cutaneous reactions (as in SJS or TEN)
Amoxicillin, Ampicillin, and Bactrim
____ is when neutrophils fail to adhere to vascular endothelium
Leukocyte adhesion defect
____ is when there is a defect in intracellular killing. Lack of superoxidase after phagocytosis.
Chronic Granulomatous Disease
Chronic granulomatous disease is inherited this way
x-linked recessive
How do you test the complement pathway function?
CH50
What type of immune mediated pathway is involved in hemolytic anemia
Type II
Serum sickness, Henoch-Schonlein purpura, and post-strep. Glomerulonephritis are all cause by type ____ reactions
Type III
Infants with eczema have lesions on _______ surfaces
Facial
Older children and with eczema have lichenification on ____ surfaces
Flexural
Asthma tests include
Lung fxn, peak flow, CXR, ABGs, eosinophil count
Causes of cough in the first months of life = CRADLE
CF RTI Aspiration Dyskinetic cilia Lung malformation Edema
In the Asthma Action Plan:
Green = ______% of the peak expiratory flow rate
Yellow = ______
Red = ____
Green = 80-100% Yellow = 50-80% Red = below 50%
This classification of asthma requires no daily medications
Mild intermittent