Midterm Chapter 6 Antitubercular Antibiotics to Azole Antifungal

Question 1

Bacteria Source of Rifampin

Answer 1

Streptomyces mediterranei

Question 2

It is the most active agent againts TB

Answer 2

Rifampin
-Enzyme Inducer-Toxic Effect are relatively Infrequent
-Drugs taken combination with INH or ethambutol causes Higher hepatoxicty
-S/E : Reddish color body secretion and Hepatoxicity

Question 3

Drugs that came from Streptomyces mediterranei

Answer 3

Rifampin
Rifamycins
Rifabutin

Question 4

Brand Name for Rifampin

Answer 4

Rifadin
Rimactane
Rifampicin

Question 5

In Rifampin , this drugs taken combination can cause higher hepatoxicity

Answer 5

INH or Ethambutol

Question 6

First line Treatment for TB

Answer 6

(RIPES)

Rifampin
Isoniazid
Pyrazinamide
Ethambutol
Streptomycin

Question 7

Standard Duration of Treatment in TB

Answer 7

Total Duration: 6 Months of Treatment:

————PTB= 2 Months RIPES or RIPE (Depends on Case)
————Maintenance Phase= 4 Months (R+I)

Total Duration :6 Months

Question 8

Cycloserine Brand

Answer 8

Seromycin (R)

Question 9

Clycloserine bacterial source

Answer 9

Streptomyces orchidaceus
Streptomyces garyphalus
Streptomyces lavendulus

Question 10

Cycloserine Moa

Answer 10

Prevent synthesis of cross-linking peptide in formation of bacterial cell wall

Question 11

Bacteria Source of Capreomycin

Answer 11

Streptomyces capreolus

Question 12

-Only Aminogylosides used for tuberculos
-first Antibiotic effectuve treatment for TB (1944 by Waksman)

Answer 12

Streptomycin

Question 13

First Antibiotic effective Treatment of Tuberculosis

Answer 13

Streptomycin

Question 14

Study of fungi

Answer 14

Mycology

Question 15

Also known as Oral Thrush

Answer 15

Candida albicans

Question 16

Studied the Trichophyton schoenleinii (1839)

Answer 16

Schonlein and Gruby

Question 17

Reported yeast like microorganism responsible for oral thrush

Answer 17

Langenbeck

Question 18

Oral thrush causes by?

Answer 18

Candida albicans

Question 19

2 types of fungal infection

Answer 19

Superficial mycoses
Deep-seated mycoses

Question 20

-Most common Groups of fungal Infection
-Caused by dermatophytes
-Tinea/Ringworm infection or Candida Infection

Answer 20

Superficial mycoses

Question 21

True or False?
Is Ringworm infection are caused by worms?
if false, what causes ringworm?

Answer 21

False, Ringworm infection are caused by fungi, not worm ! 😤

Question 22

Types of fungi that cause skin,hair and nail infection

Answer 22

Dermatophytes

Question 23

Ringworm Infection:
Which part of the body does Tinea capitis found?

Answer 23

Head/Scalp

Question 24

Ringworm Infection:
Which part of the body does Tinea barbae found?

Answer 24

Beard area

Question 25

Ringworm Infection: Which part of the body does Tinea faceie found?

Answer 25

Face

Question 26

Ringworm Infection: Which part of the body does Tinea cruris found?

Answer 26

Groin

Question 27

Ringworm Infection: Which part of the body does Tinea pedis found? Other term: Athlete’s foot

Answer 27

Feet

Question 28

Ringworm Infection: Which part of the body does Tinea manuum found?

Answer 28

Hand

Question 29

It is a microflora to the skin and at the same time opportunistic Found in Oily area/Skin surface

Answer 29

Pityriasis versicolor

Question 30

Old Name:Pityriasis versicolor New name:

Answer 30

Old Name:Pityriasis versicolor New name: Malasseria furfur

Question 31

List of Systemic Mycoses

Answer 31

Hsb-ccp Histoplasmosis Sporotrichosis Blastomycosis Coccidioidomycosis Cryptococcosis Paracoccidioidomycosis

Question 32

Opportunistic Fungal Infection

Answer 32

SamP Systemic Candidiasis Aspergillosis Mucormycosis Pneumocystis carinii

Question 33

Cutaneuos Infection (Dermatophytoses)

Answer 33

MTEM Microsporum Trichophyton Epidermophyton Malasseria furfur

Question 34

refers to a group of fungal diseases in which both the skin and subcutaneous tissue are involved but typically no dissemination to the internal organ occurs

Answer 34

Subcutaneous fungal infection

Question 35

Referst to Tinea or Ringworm

Answer 35

Dermatophytoses

Question 36

TOPICAL AGENT FOR DERMATOPHYTOSES

Answer 36

Sebum(Fatty Acid) Propionic Acid Zinc Propionate Sodium caprylate Undecylenic acid Triacetin Salicylic acid Whitfield’s Oitment

Question 37

-acidic -fatty acid substance in or on skin - Natural antifungal agent (function - Innate Immune system (Part)

Answer 37

Sebum

Question 38

-antifungal agent -no irritating and Nontoxic

Answer 38

Propionic acid

Question 39

-unstable to moisture -forming zinc hydroxide and propionic acid -used as Fungicide (ADHESIVE TAPE)

Answer 39

Zinc Propionate

Question 40

Source : Caprylic acid (Coconut/palm oil) Topical Treatment superficial (Dermatomycoses) -Candida albican -Trichophyton -Epidermophyton -Microsporum

Answer 40

Sodium Caprylate

Question 41

“10-undecenoic acid” -from destructive distillation of CASTOR OIL -Up to 10% Concentration (Used can be) -Treatment for ATHLETE’S FOOT

Answer 41

Undecylenic Acid

Question 42

-Activity - Due to acetic acid released by (Hydrolysis) of compound) by esterases present in the skin

Answer 42

Triacetin

Question 43

Poor antifungal agent Antiseptic And keratolytic properties

Answer 43

Salicylic acid

Question 44

Content: -Petroleum base -6% benzoic acid (Antiseptic Agent) antiseptic -6% salicyclic acid (keratolytic agent) penetration

Answer 44

Whitefield’s ointment