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NAPLEx > Migraine > Flashcards

Migraine Flashcards

1
Q

migraine triggers

A
  • hormonal changes in women
  • floods
  • stress
  • sensory stimuli
  • changes in wake-sleep pattern
  • changes in the environment
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2
Q

triptans

A

agonists for 5-HT1 receptors cause vasoconstriction of cranial blood vessels, inhibit neuropeptide release and decrease pain transmission

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3
Q

rizatriptan

A

Maxalt-MLT

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4
Q

Sumatriptan

A

Imitrex
Imitrex STATdose system
Zembrace SymTouch
Onzentra Xsail

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5
Q

Zolmitriptan

A

Zomig ZMT

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6
Q

long-acting triptans

A

flovatriptan (frova)- t1/2 26hrs longest
frovatriptan and naratriptan are considered the long-acting but onset is slower

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7
Q

triptans w/ a shorter t1/2 but faster onset

A

almotriptant, eletripatna, rizatriptan, sumatriptan, zolmitriptan

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8
Q

triptans… nasal spray, treximet, maxalt-MLT and Zomig ZMT ODTs

A

maxalt-MLT and Zomig ZMT ODTs- contain phenylalanine so avoid in PKU pts
nasal spray contains only 1 dose, do not prime!!
treximet: dispense in original contain protect from moister.

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9
Q

triptan formulation tablet

A

All triptans

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10
Q

triptan formulation ODT

A

Rizatriptan (Maxalt-MLT)
Zolmitriptan (Zomig ZMT)

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11
Q

triptan formulation spray/powder

A

spray:
sumatriptan (Imitrex)
Zolmitriptan (Zomig)

Powder:
Sumatriptan (Onzetra Xsail)

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12
Q

triptan formulation SC injection

A

prefilled syringe:
sumatriptan

autoinjector:
Sumatriptan (Imitrex STATdoe system, Zembrace Symtouch)

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13
Q

ergotamine

A

nonselective agonists of serotonin receptors

contra and box warning: w/ cyp3A4 inhibitors due to serious and life-treating peripheral ischemia
avoid in pt w/CV risk due to cerebrovascular events…

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14
Q

D.H.E 45, Migranal

A

Dihydroergotamine
(IM/SC/IV), nasal spray
prime nasal spray by pumping 4 times
avoid w/ or within 14 days of MOA
- ergotamine

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15
Q

rimegepant

A

Nuretc ODT
oral CGRP receptor anatagonist
- prevent and tx acute migraines
do not use w/ strong 3A4 inhibitors

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16
Q

ubrogepant

A

Ubrelvy
oran CGRP receptor anataognst
- tx acute migraine attacks

17
Q

Lasmiditan

A

Reyvow
- first in the class serotonin agonists that is selective for 5-HT1F
- unlike triptans and ergotamine- it does not cause vasoconstriction

18
Q

oral prophylactic drugs

A

prpranolol
metoprolol
timolol
divalproex
topiramate

19
Q

divalproex

A

valproic acid
Depakote
boxed warning: fetal harm, hepatic failure, pancreatitis
SE: weight gain!!, thrombocytopenia!!, increase ammonia!!, and alopecia!!

20
Q

topiramate

A

topamax
warning: fetal harm, metabolic acidosis!!, nephrolithiasis, increase ammonia, open-angle glaucoma and visual field defects, oligohidrosis (no sweating!)
SE: weiht loss, somnolence, cognitive impairment

21
Q

botox

A

botulinum tox type A, only for chronic migraines >=15 headache days per month

NAPLEx (75 decks)

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