Misc Flashcards
Which of the following is not a narcotic analgesic?
Levorphanol
Oxycodone
Fentanyl
Dextromethorphan
Hydromorphone
Dextromethorphan
Oxazepam is a metabolite of:
Nitrazepam
Clorazepate and clonazepam
Flurazepam
Diazepam and flurazepam
Chlordiazepoxide, diazepam and clorazepate
Chlordiazepoxide, diazepam and clorazepate
Alcohol is:
Distributed throughout the total body water
Metabolized by the kidneys
A mild stimulant
Largely excreted unchanged
Metabolized by lactate dehydrogenase
Distributed throughout the total body water
The relationship that exists between the weight of alcohol distributed between the air phase and the aqueous phase in a closed system at equilibrium is described as:
Henry’s Law
Widmark’s Law
Charles’ Law
Dubowski’s Law
Levine’s Law
Henry’s Law
Hemolysis is a characteristic toxic effect of which of the following?
Arsine
Thallium
Mercury
Lead
Nickel
Arsine
The concentration of ethanol in the blood can be estimated from urine. A urine ethanol concentration of 260 mg/dL is equivalent to a post-absorptive blood ethanol level of:
260 mg/dL
200 mg/dL
130 mg/dL
348 mg/dL
65 mg/dL
200 mg/dL
Knowing the Volume of Distribution (Vd) of a drug and its plasma concentration (Cp), it is possible to estimate the administered dosage (D) by using the formula:
D=Cp x Vd
D = Cp / Vd
D = Vd / Cp
D = 0.693 / Cp x Vd
D = 0.693 x Cp
D=Cp x Vd
This container type does not contain any preservative:
Red top tube
Royal blue top tube
Green top tube
Gray top tube
Lavender top tube
Red top tube
In performing a benzodiazepine test, the ability of a method to distinguish between diazepam and other benzodiazepines is a function of its:
Precision
Reproducibility
Specificity
Accuracy
Sensitivity
Specificity
The following drug is frequently analyzed in plasma specimens by GC-NPD is:
Ethanol
Doxepin
Chlordane
Tetrahydrocannabinol
Acetone
Doxepin
Drug A is more polar than Drug B. In a reverse-phase chromatography system:
Drug A has a longer retention time than Drug B
Drug A elutes before Drug B
Increasing the polarity of the mobile phase means Drug B and Drug A elute at the same retention time
Increasing the polarity of the mobile phase means Drug B elutes before Drug A
Drug A elutes after Drug B
Drug A elutes before Drug B
Which one of the following compounds is a conjugating agent used by the human liver in detoxification metabolism?
Hyaluronic acid
Aspartic acid
Lactic acid
Benzoic acid
Glucuronic acid
In a zero-order process:
Drugs are eliminated at the same rate as a first-order processes
A half-life cannot be determined
The amount of drug eliminated from the body occurs at an inconsistent rate
A constant amount of drug is eliminated per unit time
A constant fraction of drug is eliminated per unit time
A constant amount of drug is eliminated per unit time
One way to increase the migration of a non-polar solute on a non-polar adsorbent is to:
Add more polar solvent
Decrease the amount of solute
Increase the volume of solvent mixture
Add a more non-polar solvent
None of the above
Add a more non-polar solvent
Which one of the following analytical methods gives the most information about the structure of organic compounds?
Atomic absorption spectroscopy
Fluorimetry
Gas chromatography
Flame photometry
Infrared spectrophotometry
Infrared spectrophotometry
The Henderson-Hasselbach equation is used to calculate the pH of pOH of a solution containing a:
Buffer system
Salt of a strong acid and strong base
Salt of a weak acid and strong base or a salt of a strong acid and weak base
Weak acid or weak base
Strong acid or strong base
Buffer system
An electron-capture detector measures:
The number of coulombs consumed
A decrease in standing current
A decrease in radioactivity
An increase in radioactivity
An increase in standing current
A decrease in standing current
The injection port of a gas chromatography is generally kept at a temperature:
At a temperature just hot enough to produce instantaneous evaporation of the entire sample
300 degrees higher than the oven temperature
100-200 degrees lower than the oven temperature
At the same temperature as the initial oven temperature
25-50 degrees lower than the oven temperature
At a temperature just hot enough to produce instantaneous evaporation of the entire sample
An n-demethyl metabolite of cocaine produced by liver cytochrome p450:
Methylecgonidine
Ethylcocaine
Ecgonine methyl ester
Benzoylecgonine
Norcocaine
Norcocaine
A transesterification product formed when cocaine is used with alcohol:
Benzoylecgonine
Ecgonine methyl ester
Norcocaine
Ethylcocaine
Methylecgonidine
Ethylcocaine
A homogenous immunoassay where the label attached to the drug is glucose-6-phosphate dehydrogenase:
ELISA
EMIT
FPIA
CEDIA
KIMS
EMIT
Removal of the liquid mobile phase in LC-MS is a process called:
Dissociation
Electrospray ionization
Desolvation
Chemical ionization
Atmospheric pressure ionization
Desolvation
These are the two main functions of the LC-MS interface:
Desolvation and ionization
Dissociation and ionization
Desolvation and dissociation
Desolvation and ion isolation
Ionization and ion isolation
Desolvation and ionization
In MS/MS analysis, this quadrupole functions as the collision cell:
Q1
Q2
Q3
Q4
Q2