Misc Flashcards

1
Q

Which of the following is not a narcotic analgesic?

Levorphanol
Oxycodone
Fentanyl
Dextromethorphan
Hydromorphone

A

Dextromethorphan

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2
Q

Oxazepam is a metabolite of:

Nitrazepam
Clorazepate and clonazepam
Flurazepam
Diazepam and flurazepam
Chlordiazepoxide, diazepam and clorazepate

A

Chlordiazepoxide, diazepam and clorazepate

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3
Q

Alcohol is:

Distributed throughout the total body water
Metabolized by the kidneys
A mild stimulant
Largely excreted unchanged
Metabolized by lactate dehydrogenase

A

Distributed throughout the total body water

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4
Q

The relationship that exists between the weight of alcohol distributed between the air phase and the aqueous phase in a closed system at equilibrium is described as:

Henry’s Law
Widmark’s Law
Charles’ Law
Dubowski’s Law
Levine’s Law

A

Henry’s Law

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5
Q

Hemolysis is a characteristic toxic effect of which of the following?

Arsine
Thallium
Mercury
Lead
Nickel

A

Arsine

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6
Q

The concentration of ethanol in the blood can be estimated from urine. A urine ethanol concentration of 260 mg/dL is equivalent to a post-absorptive blood ethanol level of:

260 mg/dL
200 mg/dL
130 mg/dL
348 mg/dL
65 mg/dL

A

200 mg/dL

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7
Q

Knowing the Volume of Distribution (Vd) of a drug and its plasma concentration (Cp), it is possible to estimate the administered dosage (D) by using the formula:

D=Cp x Vd
D = Cp / Vd
D = Vd / Cp
D = 0.693 / Cp x Vd
D = 0.693 x Cp

A

D=Cp x Vd

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8
Q

This container type does not contain any preservative:

Red top tube
Royal blue top tube
Green top tube
Gray top tube
Lavender top tube

A

Red top tube

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9
Q

In performing a benzodiazepine test, the ability of a method to distinguish between diazepam and other benzodiazepines is a function of its:

Precision
Reproducibility
Specificity
Accuracy
Sensitivity

A

Specificity

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10
Q

The following drug is frequently analyzed in plasma specimens by GC-NPD is:

Ethanol
Doxepin
Chlordane
Tetrahydrocannabinol
Acetone

A

Doxepin

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11
Q

Drug A is more polar than Drug B. In a reverse-phase chromatography system:

Drug A has a longer retention time than Drug B
Drug A elutes before Drug B
Increasing the polarity of the mobile phase means Drug B and Drug A elute at the same retention time
Increasing the polarity of the mobile phase means Drug B elutes before Drug A
Drug A elutes after Drug B

A

Drug A elutes before Drug B

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12
Q

Which one of the following compounds is a conjugating agent used by the human liver in detoxification metabolism?

Hyaluronic acid
Aspartic acid
Lactic acid
Benzoic acid
Glucuronic acid

A
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13
Q

In a zero-order process:

Drugs are eliminated at the same rate as a first-order processes
A half-life cannot be determined
The amount of drug eliminated from the body occurs at an inconsistent rate
A constant amount of drug is eliminated per unit time
A constant fraction of drug is eliminated per unit time

A

A constant amount of drug is eliminated per unit time

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14
Q

One way to increase the migration of a non-polar solute on a non-polar adsorbent is to:

Add more polar solvent
Decrease the amount of solute
Increase the volume of solvent mixture
Add a more non-polar solvent
None of the above

A

Add a more non-polar solvent

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15
Q

Which one of the following analytical methods gives the most information about the structure of organic compounds?

Atomic absorption spectroscopy
Fluorimetry
Gas chromatography
Flame photometry
Infrared spectrophotometry

A

Infrared spectrophotometry

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16
Q

The Henderson-Hasselbach equation is used to calculate the pH of pOH of a solution containing a:

Buffer system
Salt of a strong acid and strong base
Salt of a weak acid and strong base or a salt of a strong acid and weak base
Weak acid or weak base
Strong acid or strong base

A

Buffer system

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17
Q

An electron-capture detector measures:

The number of coulombs consumed
A decrease in standing current
A decrease in radioactivity
An increase in radioactivity
An increase in standing current

A

A decrease in standing current

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18
Q

The injection port of a gas chromatography is generally kept at a temperature:

At a temperature just hot enough to produce instantaneous evaporation of the entire sample
300 degrees higher than the oven temperature
100-200 degrees lower than the oven temperature
At the same temperature as the initial oven temperature
25-50 degrees lower than the oven temperature

A

At a temperature just hot enough to produce instantaneous evaporation of the entire sample

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19
Q

An n-demethyl metabolite of cocaine produced by liver cytochrome p450:

Methylecgonidine
Ethylcocaine
Ecgonine methyl ester
Benzoylecgonine
Norcocaine

A

Norcocaine

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20
Q

A transesterification product formed when cocaine is used with alcohol:

Benzoylecgonine
Ecgonine methyl ester
Norcocaine
Ethylcocaine
Methylecgonidine

A

Ethylcocaine

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21
Q

A homogenous immunoassay where the label attached to the drug is glucose-6-phosphate dehydrogenase:

ELISA
EMIT
FPIA
CEDIA
KIMS

A

EMIT

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22
Q

Removal of the liquid mobile phase in LC-MS is a process called:

Dissociation
Electrospray ionization
Desolvation
Chemical ionization
Atmospheric pressure ionization

A

Desolvation

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23
Q

These are the two main functions of the LC-MS interface:

Desolvation and ionization
Dissociation and ionization
Desolvation and dissociation
Desolvation and ion isolation
Ionization and ion isolation

A

Desolvation and ionization

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24
Q

In MS/MS analysis, this quadrupole functions as the collision cell:

Q1
Q2
Q3
Q4

A

Q2

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25
In a first-order process: Drugs are eliminated at the same rate as a first-order processes The amount of drug eliminated from the body occurs at an inconsistent rate A half-life cannot be determined A constant amount of drug is eliminated per unit time A constant fraction of drug is eliminated per unit time
A constant fraction of drug is eliminated per unit time
26
The main purpose is to increase the water solubility of compounds to facilitate elimination: Phase I metabolism First-pass effect Hepatic excretion Phase II metabolism Renal excretion
Phase II metabolism
27
When performing a liquid/liquid extraction the pH should be adjusted to create: Salts Non-ionized drug Amphoteric drug Ionized drug Isoelectric drug
Non-ionized drug
28
Microorganism activity in whole blood can be prevented by the addition of this substance: EDTA Potassium oxalate 1% sodium citrate 1% sodium fluoride Lithium heparin
1% sodium fluoride
29
When testing for CO by Conway diffusion a solution containing this substance is added to the center well: Sodium hydrosulfite 1% o-cresol and ammonium hydroxide Palladium chloride Sulfuric Acid Trinder reagent
Palladium chloride
30
The addition of this substance reduces oxyhemoglobin and methemoglobin to hemoglobin while leaving carboxyhemoglobin unaffected: Sulfuric Acid Trinder reagent 1% o-cresol and ammonium hydroxide Sodium hydrosulfite Palladium chloride
Sodium hydrosulfite
31
The acetylation of morphine yields this substance: Norcodeine Hydromorphone 6-acetylmorphine Codeine Heroin
Heroin
32
The collection of blood in a collection container with this preservative can produce falsely elevated GHB concentrations: Lithium heparin 1% sodium fluoride Potassium oxalate Citrate 1% sodium citrate
Citrate
33
The type of LC when the stationary phase is very polar and the mobile phase has low polarity: Normal phase chromatography Non-polar phase chromatography Polar phase chromatography Gradient elution chromatography Reverse phase chromatography
Normal phase chromatography
34
The type of MS where only a few mass-to-charge ratios are monitored: Full scan Collision-induced dissociation Full monitoring Selected ion monitoring Specific ion monitoring
Selected ion monitoring
35
When preparing samples, one sample inadvertently had 1/2 the internal standard added. One approach to obtain the drug concentration in the sample is to: Divide the raw result by 2.5 Multiply the raw result by 2 Divide the raw result by 2 Multiply the raw result by 2.5 Divide the raw result by 0.5
Divide the raw result by 2
36
This substance produces a metabolic acidosis with severe visual disturbances leading to blindness: Ethanol Methanol Isopropanol Acetone Ethylene glycol
Methanol
37
This substance produces a metabolic acidosis with hypocalcemia and calcium oxalate crystalluria: Methanol Isopropanol Acetone Ethanol Ethylene glycol
Ethylene glycol
38
This substance binds Hb about 200 times more strongly than oxygen: Arsine CO CN As COHb
CO
39
Treatment for overdose includes naloxone: Cocaine Opiates Benzodiazepines PCP Ethanol
Opiates
40
True/False: Blood and plasma concentrations are not necessarily equivalent with many toxicants
True
41
True/False: Heroin is an active drug even before it is metabolized to 6-acetylmorphine.
False
42
True/False: Cocaine metabolism is an example of ester hydrolysis.
True
43
True/False: Alcohol has an affinity for water and distributes itself throughout the body organs and tissues in proportion to their water content.
True
44
True/False: Blood alcohol concentration is proportional to the volume of alcohol consumed, but inversely related to the volume of distribution in an individual.
True
45
True/False: Small amounts of CN may be produced during long-term refrigerated storage of whole blood specimens.
True
46
True/False: Heroin is rapidly inactivated in blood by hydrolysis to 6-acetylmorphine and morphine.
False
47
True/False: Carboxyhemoglobin saturation of the blood can be determined by oxidation of the oxyhemoglobin to hemoglobin.
False
48
True/False: The approximate blood:breath concentration ratio for ethanol is 1:2100.
False
49
True/False: Carbon monoxide poisoning causes a characteristic blue-green coloration of the skin.
False
50
Advantages of IV injection include: Blood concentrations are not affected by apparent volume of distribution Serum protein binding has less effect on pharmacokinetics Avoids first pass metabolism Can regulate dose by rate of infusion C and D
C and D
51
A characteristic feature of any form of chromatography is the: Calculation of an Rf value for the separated analytes Use of a mobile and a stationary phase Use of an inert carrier gas Separation of analytes that soluble in water All of the above
Use of a mobile and a stationary phase
52
This is an important determinant of renal elimination of PCP: Blood pH Urine pH Hepatic function Route of administration Volume of Distribution
Urine pH
53
A standard containing acetone is injected on a gas chromatograph at 50°C. The acetone produces a peak at 4.2 minutes. A sample is then injected on the same gas chromatograph. There are peaks at 3.1, 4.2 and 7.4 minutes. In can be concluded that: The mixture has three components, but acetone is not one of them The mixture has at least three components, one of which must be acetone The mixture has at least three components, one of which might be acetone The mixture has three components, one of which must be acetone The mixture has at least three components, but acetone is not one of them
The mixture has at least three components, one of which might be acetone
54
The process by which a compound is chemically changed, producing a new compound that has properties more amenable to a particular analytical method: Derivatization Phase I metabolism Phase II metabolism Reduction Sulfation
Derivatization
55
Silylation, acylation and alkylation: Three basic types of derivatization used in ion-exchange chromatography separations Three basic types of derivatization used in all chromatography separations Three basic types of derivatization used in gas chromatography separations Three basic types of derivatization used in liquid chromatography separations Three basic types of derivatization used in ion chromatography separations
Three basic types of derivatization used in gas chromatography separations
56
To separate neutral drugs from alkaline drugs in an organic solvent after a simple extraction, the analyst would: Filter the solvent Employ a pH 7.5 buffer wash of the solvent Evaporate the solvent to dryness Extract the solvent with 0.1N HCl Centrifuge to solvent
Extract the solvent with 0.1N HCl
57
The most effective method for distinguishing between d- and l- methamphetamine without using a chiral derivatizing agent is: Liquid Chromatography Mass spectrometry Ultraviolet spectrophotometry Gas chromatography ELISA
ELISA
58
Drugs that tend to produce very low serum concentrations at therapeutic doses are: Acidic drug (e.g., barbiturates) Neutral drugs (e.g., meprobamate) Volatile substances (e.g., ethanol) Alkaline drugs (e.g., desipramine) A and D
Alkaline drugs (e.g., desipramine)
59
How long approximately would it take for a person with a post-absorption blood alcohol concentration of 0.30% to metabolize all the alcohol in his body? 0.30% is not compatible with life 20 hours 2 hours 200 hours 7.5 hours
20 hours
60
After an acute dose of cocaine, brain concentrations of this neurotransmitter increase rapidly and then decrease to below normal concentrations: Glutamate Dopamine GABA Norepinephrine Serotonin
Dopamine
61
This substance is the primary psychoactive ingredient in marijuana: Cannabidiol Cannabinol 11-OH-THC Delta-9-carboxy THC Delta-9 THC
Delta-9 THC
62
If the lipid solubility of a barbiturate is increased: The potency of the drug and the duration of action decreases The duration of action increases The potency of the drug is decreased, but the duration of action increases The potency of the drug is increased, but the duration of action decreases The potency of the drug is decreased
The potency of the drug is increased, but the duration of action decreases
63
The degree of response in an immunoassay to a substance other than the analyte of interest: Avidity Cross-reactivity Accuracy Affinity Efficiency
Cross-reactivity
64
The main diuretic effect of ethanol is due to: The increase in the secretion of the antidiuretic hormone The inhibition of the secretion of the diuretic hormone The increase of the secretion of the diuretic hormone The inhibition of the secretion of the antidiuretic hormone None of the above
The inhibition of the secretion of the antidiuretic hormone
65
LSD is in this hallucinogen category: Tryptamines Ergolines Beta-carbolines Phenylalkylamines Indolyalkylamines
Indolyalkylamines
66
The actions of PCP of this neurotransmitter system are thought to account for the main effects on behavior: NMDA Dopaminergic Adrenergic GABA Cholinergic
Dopaminergic
67
This effect is observed in approximately 50% of PCP intoxications: Coma Rhabdomyolysis Generalized tonic-clonic seizures Hyperthermia Hypertension
Hypertension
68
This drug has some medicinal value, but with a high potential for abuse: GHB Cocaine Marijuana Morphine PCP
Cocaine
69
This substance has been used as a marker for poppy seed ingestion: Papaverine Thebaine Acetylcodeine Morphine-3-glucuronide 6-acetylmorphine
Thebaine
70
This is the major inhibitory neurotransmitter in the brain and has two subtypes: GABA Dopamine Flumazenil Norepinephrine Serotonin
GABA
71
Conjugation with glucuronide acid: Makes the analyte less polar Makes the analyte more non-polar Phase I metabolism Creates more pharmacologic active metabolites Phase II metabolism
Phase II metabolism
72
This drug is frequently used for detoxification and maintenance of opioid dependence persons: Naloxone Methadone Clonazepam Alprazolam Naltrexone
Methadone
73
Carbon monoxide is: Heavier than air A smelly, dangerous gas A cardiac sensitizer Impossible to measure by gas chromatography None of the above
None of the above
74
True/False: The metabolism of diazepam to nordiazepam is an example of an oxidative reaction.
True
75
True/False: If a weakly basic drug is given by intravenous injection, you may assume that it will not be found in the stomach.
False
76
True/False: Cyanide exhibits its toxic effects by producing the same type of hypoxia as carbon monoxide.
False
77
True/False: In medicine, the LD50 of a drug is always greater than its ED50.
True
78
True/False: Isopropyl alcohol is more toxic than methyl alcohol.
False
79
True/False: Aspirin is rapidly hydrolyzed in the blood to salicylate.
True
80
True/False: Acidic and neutral drugs generally produce higher serum concentrations at therapeutic dosages than do alkaline drugs.
True
81
True/False: The deposition of any toxic substance in bone renders it harmless.
False
82
True/False: Phenobarbital is a long-acting barbiturate.
True
83
True/False: Metabolites are generally more polar and exhibit greater water solubility than their parent substances.
True
84
When blood is unavailable and carboxyhemoglobin testing is required the next best specimen to use is: Liver Bile Vitreous Kidney Spleen
Spleen
85
Under SAMHSA guidelines, a test result may be "Rejected for Testing" due to: The presence of glutaraldehyde A Fatal Flaw Abnormal physical characteristics Abnormal pH Immunoassay interference
A Fatal Flaw
86
The apparent volume of distribution is: The theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood. The theoretical volume that would be necessary to contain half the amount of an administered drug at the same concentration that it is observed in the blood. The theoretical volume that would be necessary to contain half the amount of an administered drug at the same concentration that it is observed in the tissue. The theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the tissue.
The theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood.
87
What organ is responsible for metabolism in the first pass effect? Kidney Liver Spleen Brain Heart
Liver
88
This prolongs the persistence of a drug in the body and may lead to delayed toxicity: Absorption Bioavailability Enterohepatic circulation First pass metabolism First order elimination
Enterohepatic circulation
89
If a drug is ___ % bound to plasma proteins, only 90% can exhibit biological activity. 15% 50% 95% 85% 10%
10%
90
The 3-o-methylation of morphine to produce codeine yields a drug that: Has greater lipid solubility Is a weaker narcotic analgesic Is partially metabolized to morphine All of the above None of the above
All of the above
91
Cyanide produces toxicity by: Displacement of oxygen from the body Inhibition of rhodanase Irritation of mucous membranes Binding to the iron of methemoglobin Inhibition of cytochrome oxidase
Inhibition of cytochrome oxidase
92
Hypertension, hyperthermia, delirium and convulsions would most likely be observed after overdosage with: Alcohol Diazepam Morphine Amphetamine Pentobarbital
Amphetamine
93
The following is seen in severe salicylate poisoning: Respiratory alkalosis Metabolic acidosis Hyperpyrexia Tinnitus All of the above
All of the above
94
Which of the following statements is most correct? Lead absorbed by the body tends to accumulate Lead can be detected by the Fujiwara test Any amount of lead in the body is considered serious Tolerance to lead develops with continued exposure Most cases of lead poisoning result from accidental ingestion of lead-containing drugs
Lead absorbed by the body tends to accumulate
95
This drug acts as a competitive GABA antagonist in humans: Diazepam GHB Flumazenil Zolpidem Flurazepam
Flumazenil
96
GHB may only be detected a maximum of __ hours in blood and __ hours in urine. 8, 10 4, 12 4, 6 8, 12 2, 8
8, 12
97
In a patient with a blood barbiturate concentration of 30 mcg/mL, one would expect to observe: Hypotension Unable to determine without more information Death Coma Respiratory depression
Unable to determine without more information
98
Chlorpromazine, fluphenazine and thioridazine are: Dibenzoxazepines Benzamides Dihydroindoles Phenothiazines Thioxanthenes
Thioxanthenes
99
In people who smoke the carboxyhemoglobin concentration may be has high as: 2% 10% 4% 20% 15%
10%
100
The primary target organ of cyanide is: The liver The lungs The bone marrow The heart The brain
The brain
101
The major pathway of detoxification of cyanide is by: Binding to iron in the hemoglobin molecule Enzymatic conversion to cyanogenic glycosides Enzymatic conversion thiosulfate Hydrolytic conversion to thiocyanate Enzymatic conversion to thiocyanate
Enzymatic conversion to thiocyanate
102
This is a common sequel to long-term, high dose use of stimulants: Convulsions Hallucinations Flashbacks Lethargy Progression from oral to intravenous drug use
Convulsions
103
This drug has been used to reduce the effects of alcohol withdrawal: Clonazepam Temazepam Diazepam Flumazenil Lorazepam
Diazepam
104
In spectrophotometry, a linear relationship is usually apparent between: Percent transmittance and analyte concentration Absorbance and analyte concentration Log %T and log C All of the above None of the above
Absorbance and analyte concentration
105
The first forensic toxicologist in the United States is believed to have been: Morris L. Umberger M. Orfilla R. Harger A. Gettler
A. Gettler
106
The first text written on the subject of forensic toxicology was contributed by: M. Orfilla J. March L. Umberger A. Gettler R. Harger
M. Orfilla
107
Clonazepam is relatively unstable in postmortem specimens due to: The acidic pH of postmortem blood The basic pH of postmortem blood Thermal degradation only Bacterial and thermal degradation UV sensitivity
Bacterial and thermal degradation
108
The use of this technology for the analysis of ethanol in breath has become a mainstay in evidential breath-testing devices: AAFS Diode-array detection Graphite furnace UV-VIS spectrophotometry IR
IR
109
The operation of this GC detector is uses a radioactive beta particle source to measure the degree of electron capture: FID PFPD ECD TCD NPD
110
In this GC detector electrodes are placed adjacent to a flame fueled by hydrogen / air near the exit of the column, and when carbon containing compounds exit the column they are pyrolyzed by the flame: PFPD NPD FID ECD TCD
FID
111
This GC detector is useful for analysis of drugs and pesticides containing phosphorous: NPD ECD FID PFPD TCD
NPD
112
The Vd for a drug that is completely retained in the vascular compartment would be: Low High
Low
113
The Vd for a drug highly bound in peripheral tissues would be: High Low
High
114
Codeine is best assayed as a: Neutral drug Amphoteric drug Acidic drug Alkaline drug None of the above
Alkaline drug
115
Which of the following drugs would exhibit its minimal solubility in water at pH 8.5: Amphetamine Morphine Heroin Salicylic acid Codeine
Morphine
116
One of the most common methods for the analysis of ethanol in hospital laboratories uses: Potassium dichromate and sulfuric acid Alcohol dehydrogenase Acetaldehyde dehydrogenase Alcohol hydrogenase Aldehyde dehydrogenase
Alcohol dehydrogenase
117
When the effects of ethanol are perceived to be greater when the blood ethanol concentration is ascending as opposed to descending: Henry's Law Harbinger Effect Widdemer Effect Ulster's Law Mellanby Effect
Mellanby Effect
118
When ethanol concentration increases beyond 30%, irritation of the mucosa of the GI tract occurs. This affects gastric emptying: Not at all In individuals with gastric motility disorders By increasing it By delaying it None of the above
By delaying it
119
The precision and accuracy in measurement of an analyte under a variety of analytical conditions: Reproducibility Variance Robustness Recovery efficiency Stability
Robustness
120
The most common mass analyzers: Ion trap Collision Induced Quadrupole Magnetic Sector Time-of-Flight
Quadrupole
121
In this type of assay, the labeled antigen in the reagent competes with unlabeled antigen in the patient sample for binding sites on the antibody. Competitive Non-competitive Immunoassays All of the above None of the above
Competitive
122
What is the cross-reactivity (%) of 500 ng/mL fentanyl added to an assay where the apparent concentration of the target drug (morphine) is 100 ng/mL? 0.01% 20% 0.1% 100% 1%
20%
123
Enzyme activity of G6P-DH decreases when the attached drug is bound to antibody. CEDIA FPIA ELISA KIMS EMIT
EMIT
124
A substance that stimulates an animal lymphocyte to produce an antibody that specifically binds to it. Antibody Hapten Antigen Antigenic determinant Analyte
Antigen
125
Nordiazepam accumulates in plasma during administration of: Nitrazepam Temazepam Chlordiazepoxide Oxazepam Flurazepam
Chlordiazepoxide
126
The respiratory clearance of carbon monoxide from blood under normal atmospheric conditions is approximately: 10% per hour 25% per hour 50% per hour 70% per hour 90% per hour
10% per hour
127
Decomposed postmortem blood samples can produce amines which often can produce false positive in this immunoassay. Cocaine Opiates Oxycodone Cannabinoids Amphetamines
Amphetamines
128
The term used when several different precursor-product ion pairs are monitored: Simultaneous reaction monitoring Multiplied reaction monitoring Selected reaction monitoring Multiple reaction monitoring Selected ion monitoring
Multiple reaction monitoring
129
Using a combination of __________ and __________ on the sets of diagonally opposed rods allows only ions of a single m/z value to pass through the analyzer. Radio Frequency Radio Frequency and DC voltages AC and DC voltages DC voltages Radio Frequency and AC voltages
Radio Frequency and DC voltages
130
This drug has mixed agonist-antagonist properties: Methadone Tramadol Buprenorphine Codeine Fentanyl
Buprenorphine
131
This is the carrier gas of choice to maximize sensitivity: Hydrogen Oxygen Nitrogen Carbon Dioxide Helium
Helium
132
The methamphetamine antibody binds methamphetamine in a sample more strongly than the labeled amphetamine. This is an example of: Competitive binding The Hook effect Cooperative binding Non-cooperative binding Non-competitive binding
Cooperative binding
133
Half Life of 6MAM
0.6 hours
134
What are the metabolites of cocaine?
EME, Norcocaine, BE, Ethylcocaine, Methylecgonidine
135
Extraction pH of Cocaine
8-11
136
Half Life of BE
7.5 hours
137
Half Life of EME
3.6 hours