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Flashcards in misc Deck (10)
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1

erythema multiforme

necrotic keratinocytes
spongiosis, basal vacuolar changes, subepidermal blister
dermal edema
perivascular lymphocytes
extravasated RBC

2

sweets syndrome

epidermal necrotic keratinocytes
dermal edema
diffuse dermal infiltrate of neutrophils lymphocytes, histiocytes few, eosinophils
extravasated RBC
vasculitis present/absent

3

LCV

epidermis nromal /necrotic/vesicles/pustules
vasculitis small venules
predominant neut, e/l/histio
nuclear dust
RBC extravasation, thrombi

4

DIF LCV

IgG/M/complement/fibrin( splash pattern)
granular pattern
superficial blood vessels

5

PAN

-epidermis normal/necrotic/ulcerated
-leukocytoclasticvasculitis of arteries( small/medium)- deep dermis/subQ fat
-intimal proliferation/thrombi
-fibrosis older lesions

6

PAN systemic complications

brain, heart
kidney, abdominal arteriits/aneurysms
death

7

PAN cuaneous lesions

urticarial, purpura, painful red nodules
livedo reticularis, digital infarct

8

PAN underlying systemic disease

-hep B/C
-cryoglobinemia
-ANCA autoab

9

Epidermal nevus

Hyperkeratosis, papillomatosis, acanthosis, sometimes hypergranulosis ▪ Epidermolytic hyperkeratosis rarely (11.1) ▪ Acantholytic dyskeratosis rarely (11.3) ▪ Perivascular lymphocytes often

10

Epidermal nevus genetics

post-zygotic somatic mosaicism
mutations in FGFR3 gene or PIK3CA gene