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Flashcards in vacular cards Deck (13)
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1

neurofibroma


well circumscribed non encapsulated dermal proliferation
spindle cells with wavy nuclei
in pink bubblegum stroma

2

Kaposi sarcoma

Compact proliferation back-back spindle cells
Sieve like cross section, slit like vascular spaces
promontory sign +, Cytologic atypia mild, sparse mitoses
RBC vascular lumina,dermal hemosiderin
Plasma cells, eosinophilic hyaline globules (PAS positive, Mallory trichrome positive)

3

Kaposi sarcoma stains

CD31/34, hhv8

4

Angiosarcoma

poorly demarcated haphazard maze-like proliferation
Slit like vascular spaces dissecting collagen bundles
atypical spindled epitheloid cells increased cellularity mitoses and cellular atypia papillary projections lumen
prominent extravsated RBC, hemosiderin

5

Angiosarcoma stains

CD31/34/Factor 8 related ag, Ulex europaeus, negative HHV8

6

glomus tumor

Aggregates uniform cuboidal cells
proliferation blood vessels surrounded by small round blue monomorphous cells (glomus cells) filing through stroma
Copiuous cytoplasm round hyperchomatic nuclei lining vascular channels

7

glomus tumor stains

SMA + desmin +

8

lymphangioma

Epidermal hyperplasia sometimes
Proliferation and dilation of lymph vessels in dermis (especially papillary dermis) or deep soft tissue
lined by endothelial cells

9

pyogenic granuloma

epidermal collarette scale crust
Vascular lobules proliferation thin walled blood vessels in edematous pale myxoid stroma
infiltrate neutrophils, lymphocytes

10

hemangioma

proliferation vessels and endothelial cells

11

hemangioma stain

cd 31/34

12

vascular malformation

mixture thin and thicker walled blood vessels

13

Angiokeratoma

Hyperkeratosis, epidermal rete ridges often encircle dilated vessels
Dilated vessels in superficial dermis, without much endothelial proliferation
Thrombi common