Misc

Question 1

patients wth erythropoietic protoporphyria have a defect in

Answer 1

ferrochelatase

Question 2

location of split in bullous pemphigoid, cicatricial pemphigoid, PCT, EBA

Answer 2

sub-epidermal

Question 3

immunoflourescent patter in bullous pemphigoid and herpes gestationis

Answer 3

linear C3 with occasional IgG at basement membrane

Question 4

atopic derm is Th*

Answer 4

Th2

Question 5

the portion of the electromagnetic spectrum that products a particular biologic effect (e.g. erythema, delayed tanning)

Answer 5

action spectrum

Question 6

wavelength of Wood’s light

Answer 6

365nm

Question 7

how is actinic prurigo different from polymorphous light eruption?

Answer 7

AP lesions begin in childhood and remit in puberty, occur on all sunexposed areas and may occur on non-sun exposed areas, and may persist for months, and chelitis is frequently seen

Question 8

Topical and systemic agents that produce phototoxicity and/or photoallergy usually have action spectra in what range?

Answer 8

UVA

Question 9

Patients with an allergy to the compositae family may have an allergic reaction to which family of drugs?

Answer 9

Pyrethrins, insecticidal

Question 10

mosquitos that cause malaria

Answer 10

Anopheles

Question 11

Mosquitos that cause yellow fever

Answer 11

Aedes

Question 12

Mosquitos that cause dengue

Answer 12

Aedes

Question 13

Capsaicin works by ***ing substance P release

Answer 13

increasing, leading to depletion

Question 14

leading cause of necrotic arachnidism in several states of the Pacific Northwest

Answer 14

Tegenaria agrestis (hobo spider)

Question 15

The necrosis and hemolysis that can result from a brown recluse spider bite may be attributed to which of the following toxins?

Answer 15

sphingomyelinase D

Question 16

Organ transplant recipients are at risk for developing many cutaneous tumors. The risk of melanoma is ***-fold that of the general population whereas these patients have a xxx-fold increased risk of developing squamous cell carcinoma.

Answer 16

***3

xxx65

Question 17

What is the tattoo pigment responsible for most lichenoid reactions?

Answer 17

mercuric sulfide

Question 18

laser used for rhinophyma

Answer 18

carbon dioxide

Question 19

10,600 nm laser

Answer 19

carbon dioxide

Question 20

Which of the following histochemical stains can be used intraoperatively during Mohs micrographic surgery to confirm the diagnosis of extramammary Paget’s disease?

Answer 20

cytokeratin 7

Question 21

This medication is the drug of choice for erythema nodosum leprosum. It inhibits tumor necrosis factor-alpha and suppresses monocyte and neutrophil phagocytosis.

Answer 21

thalidomide

Question 22

most photosensitizing tetracycline

Answer 22

demeclocycline

Question 23

a chimeric anti-epidermal growth factor receptor antibody that is FDA approved to treat advanced colorectal cancer. Acneiform eruptions have been reported to occur in up to 1/3 of patients.

Answer 23

cetuximab

Question 24

What is the most common cause of nonpigmented fixed drug eruption?

Answer 24

pseudoephedrine

Question 25

Fibrofolliculomas are associated with

Answer 25

Birt-Hogg-Dube syndrome

Question 26

On electron microscopy, which cell demonstrates cytoplasmic projections and secretory granules

Answer 26

Mast cell

Question 27

MOA of ipilimumab

Answer 27

inhibitor of CTLA-4 (normally inhibit T-cell activation)

Question 28

Acid keratins (K10-20) are expressed on what chromosomes?

Answer 28

17

Question 29

basic keratins expressed on what chromosomes?

Answer 29

12

Question 30

Major protein component of the cornified cell envelope

Answer 30

Loricrin

Question 31

protein that is cross-linked by transglutaminase in the granular layer to form insoluble cell boundary

Answer 31

Involucrin

Question 32

Protein that links cell envelope to desmosomes and keratin filamnets

Answer 32

Envoplakin

Question 33

protein that promotes aggregation and disulfide bonding of keratine filaments in cell envelope

Answer 33

Filaggrin

Question 34

T cell subset in Sezary syndrome

Answer 34

CD4+/CD7-

Question 35

***syndrome is the leukiemia phase of MF

Answer 35

Sezary

Question 36

most common autoimmune disorder in pts with chronic hep C

Answer 36

autoimmune thyroiditis

Question 37

most common sunscreen ingrediant to cause photoallergic CD

Answer 37

oxybenzone

Question 38

Rituximab targets

Answer 38

CD20 antigen

Question 39

CD20 antigen is expressed on what cells

Answer 39

T cells

Question 40

SPINK5 mutation

Answer 40

netherton's syndrome

Question 41

SLURP1 mutation

Answer 41

Mal de Maleda

Question 42

GJB2 mutation

Answer 42

VohWinkels syndrome

Question 43

LMX1B mutation

Answer 43

Nail-Patella syndrome

Question 44

CYLD mutation

Answer 44

Familial Cylindromiasis

Question 45

syndrome: ichthyosis linearis circumflexa, trichorrhexis invaginata, atopic derm, food allergy

Answer 45

Netherton'ssyndrome

Question 46

tooth finding in tuberous sclerosis

Answer 46

enamal pits

Question 47

genodermatosis associated with BCC

Answer 47

Gorlin Syndrome

Question 48

mutation in PTCH gene

Answer 48

Gorlin syndrome

Question 49

folliculin mutation

Answer 49

Birt Hogg Dube

Question 50

PRKAR1A mutation

Answer 50

Carney

Question 51

PTEN mutation

Answer 51

Cowden and Bannayan-Zonana