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Flashcards in Misc Path Deck (18)
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1

Eliminates O2 free radical?

Superoxide dismutase

2

Eliminates OH free radical

Gutathione peroxidase

3

Eliminates H202?

Catalase

4

Types of systemic amyloidosis?

Primary (AL) and secondary (AA)

5

Derived from Ig light chain?

Primary (AL)

6

Diseases assoc with primary AL?

Plasma cell dyscrasias and multiple myeloma

7

What is secondary AA derived from?

Serum amyloid A (SAA)--acute phase reactant that is increased in chronic inflammatory states (RA, IBD, spondyloarthropathies, chronic infection), malignancy

8

Familial Mediterranean fever?

Secondary AA

9

S/S of FMF?

Episodes of fever and acute serosal inflammatio (mimics MI and acute appendicitis)

10

Most common organ affected by amyloid?

Kidney (nephrotic syndrome)

11

Non-mutated (wild type) serum transthyretin deposits?

Senile cardiac amyloidosis--usually asxs

12

Mutated serum transthyretin?

Familial amyloid cardiomyopathy--leads to restrictive cardiomyopathy

13

Amylin deposits in islets of pancreas?

T2DM--derived from insulin

14

Derived from B-amyloid precursor protein?

Alzheimer's

15

B2 microglobulin deposits?

Dialysis-assoc amyloidosis

16

What is B2 microglobulin a component of?

MHC class I

17

S/S of dialysis assoc amyloidosis?

Carpal tunnel and other joint issues

18

Calcitonin deposits within tumor?

Medullary carcinoma of thyroid