Flashcards in Misc Path Deck (18)
Eliminates O2 free radical?
Eliminates OH free radical
Types of systemic amyloidosis?
Primary (AL) and secondary (AA)
Derived from Ig light chain?
Diseases assoc with primary AL?
Plasma cell dyscrasias and multiple myeloma
What is secondary AA derived from?
Serum amyloid A (SAA)--acute phase reactant that is increased in chronic inflammatory states (RA, IBD, spondyloarthropathies, chronic infection), malignancy
Familial Mediterranean fever?
S/S of FMF?
Episodes of fever and acute serosal inflammatio (mimics MI and acute appendicitis)
Most common organ affected by amyloid?
Kidney (nephrotic syndrome)
Non-mutated (wild type) serum transthyretin deposits?
Senile cardiac amyloidosis--usually asxs
Mutated serum transthyretin?
Familial amyloid cardiomyopathy--leads to restrictive cardiomyopathy
Amylin deposits in islets of pancreas?
T2DM--derived from insulin
Derived from B-amyloid precursor protein?
B2 microglobulin deposits?
What is B2 microglobulin a component of?
MHC class I
S/S of dialysis assoc amyloidosis?
Carpal tunnel and other joint issues