MOA Flashcards

Question

Timolol

Answer 1

β receptors produce aqueous humor so you block and ↓ aqueous humor and ↓IOP

Answer 2

↓CO, ↓plasma renin release and ↓ central sympathetic tone

Answer 3

↓CO, ↓plasma renin release and ↓ central sympathetic tone

Answer 4

Blocks β2α1 in 4:1 rtio

Answer 5

Blocks β2α1 in 10:1 ratio

Answer 6

works directly at α2 receptors to 1. Tells enough NE and stops release by acting at presymaptic receptors on postganglionic neurons 2. ↓Sympathetic outflow in the brain

Answer 7

must be metabolized to α-methyl-NE to 1. Tells enough NE and stops release by acting at presymaptic receptors on postganglionic neurons 2. ↓Sympathetic outflow in the brain

Answer 8

α2 receptors n locus coeruleus to 1. Tells enough NE and stops release by acting at presymaptic receptors on postganglionic neurons 2. ↓Sympathetic outflow in the brain

Answer 9

enters via NET and concentrates in vesicle to ↓ NE over time | NE that escapes is metabolized by MAO

Answer 10

enters terminal, membrane blocks VMAT causin ↓NE | NE that escapes is metabolized by MAO

Answer 11

Releases FA that inhibit hepatic FA synthesis

Answer 12

↑ clearance of TGs

Answer 13

Direct inhibition of HMG CoA reductase which leads to ↓ cholesterol→ ↑ synthesis of hepatic LDL receptors→ ↑ LDL clearance

Answer 14

Direct inhibition of HMG CoA reductase which leads to ↓ cholesterol→ ↑ synthesis of hepatic LDL receptors→ ↑ LDL clearance

Answer 15

⊕charged so binds to bile acids (cholesterol metabolites) → prevents reabsorption of bile acids → ↑conversion of cholesterol to bile acids→ ↑LDL receptors and ↑LDL clearance from plasma Can also lead to up regulation of HMG-CoA reductase

Answer 16

Inhibits lipase and ↓ TG transport to liver→ ↓TG synthesis in liver

Answer 17

Agonist for PPAR α receptor (a transcription factor)

Answer 18

blocks degredation of LDL receptor

Answer 19

Converted to NO →↑Guanylate cyclase →↑cGMP→dephosphorylates MLC→↓conractile smooth muscles

Answer 20

Block influx of Ca→↓contractile state of smooth muscle

Answer 21

Block influx of Ca→↓contractile state of smooth muscle

Answer 22

Block influx of Ca→↓contractile state of smooth muscle | more potent on vessel than heart

Answer 23

Block influx of Ca→↓contractile state of smooth muscle more potent on vessel than heart high affinity for cerebral vessels

Answer 24

Block β1 R on heart→↓HR and ↓contraction due to ↓Calcium influx Blocks β1 and β2 ↓renin secretion→↓Ang II

Answer 25

block Na Cl pump | ↑Na in lumen→depolarizing luminal membrane→↑loss of K

Answer 26

Blocks ACE which blocks conversion of Ang I → Ang II (normally causes vasoconstriction)

Answer 27

Block pathway at receptor level AT1

Answer 28

Vasodilate arterial smooth muscle → baroreceptor reflex response

Answer 29

Vasodilate arterial smooth muscle → baroreceptor reflex response

Answer 30

Vasodilate arterial smooth muscle → baroreceptor reflex response

Answer 31

Blocks binding of NE to to α1 receptors

Answer 32

Transported into vesicles and replace NE and blocks exicatation secretion coupling at Post ganglionic peripheral nerurons

Answer 33

Binds to storage vesicles and inhibits transmitter uptake→dysfunctional vesicles bc depletion of NE at Central and peripheral vesicles

Answer 34

↓sympathetic activity→vasoconstriction

Answer 35

↓sympathetic activity→vasoconstriction

Answer 36

Vasodilates Dilates large epicardial arteries →↓coronary steal→↓LV pressure ↓Preload ↓Wall tension

Answer 37

↓contractility

Answer 38

More coronary and peripheral vasodilation than non-dihydros ↓BP ↑HR ↑Contractility

Answer 39

↓HR ↓contraction ↑Preload and tension (might want to use in combo w/ ↓preload)

Answer 40

↓preload and blood volume

Answer 41

vasodilation ↓preload and blood volume ↓LV hypertrophy

Answer 42

↓preload and blood volume

Answer 43

Vasoconstriction ↓Sympathetic Activity ↓BP

Answer 44

Block Na channels→ ↑ERP Inc K+ out→ ↓ AP Selective for sick cells

Answer 45

Block Na channels→ ↑ERP Inc K+ out→ ↓ AP Selective for sick cells

Answer 46

Selectively Na channel blocker→ ↑ERP | Inc K+ out→ ↓ AP

Answer 47

Blocks Na channels in normal cells → ↑ERP | Anticholinergic ↓vagal influences

Answer 48

Blocks Na channels in normal cells → ↑ERP | Anticholinergic ↓vagal influences

Answer 49

Blocks Na channels in normal cells → ↑ERP | Anticholinergic ↓vagal influences

Answer 50

Blocks K+ efflux → ↑APD and ↑QT Blocks Na channels→ ↑ERP

Answer 51

Blocks K+ efflux → ↑APD and ↑QT Blocks Na channels→ ↑ERP

Answer 52

Blocks K+ efflux → ↑APD and ↑QT Blocks Na channels→ ↑ERP

Answer 53

Blocks K+ efflux → ↑APD and ↑QT Blocks Na channels→ ↑ERP

Answer 54

L type Ca channel blockade ↓SA and AV node conduction ↓ contractility

Answer 55

L type Ca channel blockade ↓SA and AV node conduction ↓ contractility

Answer 56

↓AV node conduction ↓excitability ↓SA node rate ↓contractility

Answer 57

Inhibits Na+/K+ ATPase→ ↓resting mem potential ↓conduction velocity ↑vagal activity→ ↓recractory period and ↓conduction in AV node

Answer 58

↑K+ efflux and hyperpolarizes cell→ ↓ability for Ca to enter→ ↓AV node conduction and ↓automaticity

Answer 59

↑GABA binding at inhibitory GABAaR ↓Glutamate activation of excitatory NMDAR Facilitate release of endogenous opioids in VTA

Answer 60

↑GABA binding at inhibitory GABAaR | Can directly open GABAa at high concentrations

Answer 61

↑GABA binding at inhibitory GABAaR | Abuse w/ faster acting BZ (alprazolam, diazepam)

Answer 62

Activity mu-opioid receptor

Answer 63

Nicotine stimulates nAchRs in reward pathway

Answer 64

THC binds to cannabinoid receptors (GPCR) and activates the reward pthwy

Answer 65

↑ DA and NE release and block MAO

Answer 66

Blocks reuptake of NA so ↓ NE and serotonin

Answer 67

Agonist at 5HTR, DA receptors and adrengeric receptors

Answer 68

Induce 5HT and DA release 5HT reuptke inhibitor Agonist at 5HT, DA & adrenergic receptor

Answer 69

Inhibit glutamatergic NMDA receptors

Answer 70

CAH inhibitor→↓HCO3⁻ in → ↓ Na⁺ resoprtion→ ↑ luminal Na⁺ concentration (which will retain water and Cl⁻) ↓ H⁺ in Secondary: ↑tubular Na⁺→TGF activation → ↓GFR

Answer 71

↑ conc in tubule that cant be resorbed so holds onto more water ↑plasma osmolality, ↑ECFV→ ↑ RBF & ↓ osmotic gradient

Answer 72

↓ Na⁺/K⁺/2Cl⁻ Symporter → ↓ osmotic gradient Changes in macula densa sensing of Na is duiretic braking

Answer 73

Inhibits Na⁺/Cl⁻ cotransporter

Answer 74

Block ENaC → ↓ Na resoprtion and ↓ K backleak & excretion

Answer 75

Prevents aldosterone & blocks production of ENaC channel, Na/K ATPase and K channel→ ↑Na resportion→ ↑K+ excretion

Answer 76

Block V2 receptor → block aquaporins→ ↓ water resorption

Answer 77

Block conversion of ang I to ang II → ↓ preload by ↓ vasoconstriction ↓aldosterone stimulation → ↓ preload

Answer 78

Block conversion of ang I to ang II → ↓ preload by ↓ vasoconstriction ↓aldosterone stimulation → ↓ preload

Answer 79

Blocks after ang II so no cough but still ↓afterload by ↓ vasoconstriction

Answer 80

↓ HR | Blocks Na funny current in SA node which determines HR and ↓ leak

Answer 81

Releases organic nitrates→release of NO→ ↑cGMP→ uphosphorylated Myosin LC→ vasodilation

Answer 82

Dilates arterioles → ↓ afterload

Answer 83

↓ HR | Blocks Na funny current in SA node which determines HR and ↓ leak

Answer 84

Releases organic nitrates→release of NO→ ↑cGMP→ uphosphorylated Myosin LC→ vasodilation

Answer 85

Dilates arterioles → ↓ afterload

Answer 86

Myocardium: Blocks cAMP destruction → ↑ Ca⁺⁺ levels → ↑ contraction Also affects arterioles → MLCK inactivated → relaxation→ ↓ afterload

Answer 87

Blocks Na⁺/K⁺ ATPase → ↓ Na⁺ outside the cell → ↓ driving force → ↑ Ca⁺⁺ inside cell → ↑ contractility

MOA Flashcards

(111 cards)