MOD Etc. II

Question 1

Translocation for Chronic Myelogenous Leukemia (CML)

Answer 1

(9;22)

Question 2

Genes associated w/ CML

Answer 2

ABL 9q34

BCR 22q11

Question 3

Translocations for Acute Myeloid Leukemia (AML)

Answer 3

(8;21)

15;17

Question 4

Translocation for Burkitt lymphoma

Answer 4

(8;14)

Question 5

Translocation for Mantle cell lymphoma

Answer 5

(11;14)

Question 6

Translocation for Follicular lymphoma

Answer 6

(14;18)

Question 7

Gene DNMT3A

Function:
Tumor:

Answer 7

Function: DNA methylation
Tumor: AML

Question 8

Gene MLL1

Function:
Tumor:

Answer 8

Function: histone methylation
Tumor: acute leukemia in infants

Question 9

Gene MLL2

Function:
Tumor:

Answer 9

Function: histone methylation
Tumor: follicular lymphoma

Question 10

Gene CREBBP/EP300

Function:
Tumor:

Answer 10

Function: histone acetylation
Tumor: diffuse large B cell lymphoma

Question 11

Gene ARID1A

Function:
Tumors:

Answer 11

Function: nucleosome positioning/chromatin remodeling
Tumors: ovarian clear cell carcinoma, endometrial carcinoma

Question 12

SNF5

Function:
Tumor:

Answer 12

Function: nucleosome positioning/chromatin remodeling
Tumor: malignant rhabdoid tumor

Question 13

PBRM1

Function:
Tumor:

Answer 13

Function: nucleosome positioning/chromatin remodeling
Tumor: renal carcinoma

Question 14

Laboratory diagnosis of cancer - 6 methods (6)

Answer 14

Histologic

Immunohistochemistry

• cytokeratin
• epithelial membrane ag. (EMA)
• leukocyte common ag. (LCA, CD45)
• peroxidase
• non-specific esterase
• GFAP

Cytologic

Flow cytometry

Circulating tumor cells

Molecular and cytogenetic diagnostics

Question 15

Neuron-specific enolase (2)

Answer 15

Small cell carcinoma

Neuroblastoma

Question 16

TP53, APC, RAS mutants in stool and serum

Answer 16

Colon cancer

Question 17

TP53, RAS mutants in stool and serum

Answer 17

Pancreatic cancer

Question 18

TP53, RAS mutants in sputum and serum

Answer 18

Lung cancer

Question 19

TP53 mutants in urine

Answer 19

Bladder cancer

Question 20

Most common cancer of the skin

Answer 20

Basal cell carcinoma > squamous cell carcinoma > melanoma

Question 21

TP53 is the…

Answer 21

Guardian of the genome

Question 22

APC is the…

Answer 22

Gatekeeper of colonic neoplasia

Question 23

RB is the…

Answer 23

Governor of the cell cycle

Question 24

What are the targets cells of the DNA viruses that can induce cancer?

Answer 24

HPV - cervical carcinoma
HHSV8 - Kaposi sarcoma
HBV - liver disease
EBV - Burkitt lymphoma and nasolaryngeal carcinomas
MCV - Merkel cell carcinoma

Question 25

Squamous cell carcinoma is associated with which paraneoplastic syndrome?

Answer 25

Hypercalcemia

Question 26

Malignancies associated with HH/WNT in Beckwith-Wiedemann syndrome

Answer 26

Hepatoblastoma Pancreatoblastoma Adrenocortical tumors Rhabdomyosarcomas

Question 27

Most common malignancy in kids

Answer 27

B cell leukemia

Question 28

Most common solid tumor in kids

Answer 28

Medulloblastoma

Question 29

Most common extracranial tumor in kids

Answer 29

Neuroblastoma

Question 30

Immunohistochemistry techniques and what cancers they target (6)

Answer 30

Cytokeratin - skin cancers Epithelial membrane Ag - carcinomas Leukocyte C Ag (LCA) (CD45) - WBC malignancies Peroxidase - myeloid cell line malignancies Non-specific esterase - monocytic neoplasia GFAP - malignancies of glial origins

Question 31

"Major nuclear regulatory oncogene"

Answer 31

MYC

Question 32

All of the oncogenes are AD, except:

Answer 32

MSH - DNA repair factor

Question 33

Von Hippel Lindau syndrome includes (3)

Answer 33

Cerebellar hemangioblastoma Retinal angioma Renal cell carcinoma

Question 34

To perform its normal action, p53 acts through what?

Answer 34

p21 to cause apoptosis via transcription of genes like BAX

Question 35

What chromosome is p53 found?

Answer 35

17p13.1

Question 36

Xeroderma pigemtosum

Answer 36

Problem with nucleotide excision repair from UV damage

Question 37

HTLV-1 is an RNA virus that causes what malignancy?

Answer 37

Adult T cell/leukemia/lymphoma, mostly in South American countries