Moderate and other opioid agonists Flashcards Preview

23 Opioids > Moderate and other opioid agonists > Flashcards

Flashcards in Moderate and other opioid agonists Deck (12)
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1

Moderate opioid agonists - 3 drugs

Codeine
Hydrocodone
(Propoxyphene - removed)

2

Moderate opioid agonists - adm

Oral with nonopioid analgesic. High dose cause intolerable side effects.

3

Moderate opioid agonists - indications

Mild to moderate pain
Alleviate or prevent coughing.

4

Codeine - MOA

Most of the therapeutic effect is caused by metabolism to morphine.

5

Explain the different effect of codeine and hydrocodone in different patients.

Most of therapeutic effect caused by metabolism to morphine. Pts deficient in CYP2D6 have little pain relief. Pts who are ultra-rapid metabolizers may have a higher peak, and cause intoxication of fetus/infant if pregnant/nursing.

6

Other opioid agonists

Tramadol
Tapentadol
Dextromethorphan
Diphenoxylate
Loperamide

7

Tramadol - MOA

Dual-action analgesic: agonist at μ receptors and inhibits neuronal reuptake of serotonin and norepinephrine.
Analgesic effect is only partially inhibited by opioid antagonists.

8

Tramadol - indications

Moderate pain.
Chronic pain syndromes

9

Tramadol - side effects

Lowers seizure threshold
Increased risk of suicidal thoughts and behaviors.

10

Tapentadol - MOA

Acts on μ receptors and inhibit NE reuptake.

11

Dextromethorphan - indications

Antitussive (little analgesic effect).
Used with quinidine for psuedobulbar affect in neurodegenerative disease.

12

Opioids used for diarrhea

Diphenoxylate and loperamide.