Opioid antagonists Flashcards Preview

23 Opioids > Opioid antagonists > Flashcards

Flashcards in Opioid antagonists Deck (13):
1

Opioid antagonists

Naloxone
Naltrexone

2

Naloxone, naltrexone - MOA

Competitive opioid receptor antagonists. Reverse effects of opioid agonists.

3

Naloxone, naltrexone - indications

Opioid overdose.
Opioid and alcohol dependence.

4

Treatment of mild pain

NSAID

5

Treatment of moderate pain

Codeine, hydrocodone, oxycodone.
(may be used with nonopioid analgesic)

6

Treatment of severe pain

Fentanyl, meperidine, methadone, morphine.

7

Peripheral nerve pain - treatment

Local anesthetic.
Capsaicin (also postherpetic neuralgia)

8

Capsaicin - MOA

Activates peripheral nociceptors on primary sensory neurons. Increased release of substance P and eventually depletion of substance P in CNS

9

Capsaicin - adverse effects

Burning sensation the first days, replaced by analgesic effect after a few days

10

Coanalgesics

Antiepileptic drugs (carbamazepine, gabapentin, phenytoin, valproate, pregabalin)
Antidepressants (amitriptyline, desipramine)

11

Antiepileptics - indications as coanalgesics

Trigeminal neuralgia
Postherpetic neuralgia
Continuous burning neuropathic pain
Pregabalin: fibromyalgia.

12

Antidepressants - indications as coanalgesics

Amitriptyline, desipramine, other TCAs: postherpetic neuralgia, diabetic neuropathy, migraine headache, neuropathic pain syndromes.
Duloxetine, milnacipran: fibromyalgia

13

Chronic opioid adm - management of constipation

Methylnaltrexone bromide