Flashcards in Opioid antagonists Deck (13)
Naloxone, naltrexone - MOA
Competitive opioid receptor antagonists. Reverse effects of opioid agonists.
Naloxone, naltrexone - indications
Opioid and alcohol dependence.
Treatment of mild pain
Treatment of moderate pain
Codeine, hydrocodone, oxycodone.
(may be used with nonopioid analgesic)
Treatment of severe pain
Fentanyl, meperidine, methadone, morphine.
Peripheral nerve pain - treatment
Capsaicin (also postherpetic neuralgia)
Capsaicin - MOA
Activates peripheral nociceptors on primary sensory neurons. Increased release of substance P and eventually depletion of substance P in CNS
Capsaicin - adverse effects
Burning sensation the first days, replaced by analgesic effect after a few days
Antiepileptic drugs (carbamazepine, gabapentin, phenytoin, valproate, pregabalin)
Antidepressants (amitriptyline, desipramine)
Antiepileptics - indications as coanalgesics
Continuous burning neuropathic pain
Antidepressants - indications as coanalgesics
Amitriptyline, desipramine, other TCAs: postherpetic neuralgia, diabetic neuropathy, migraine headache, neuropathic pain syndromes.
Duloxetine, milnacipran: fibromyalgia