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Flashcards in Strong opioid agonists Deck (17):
1

Strong opioid agonists - 8 drugs

Morphine
Fentanyl
Meperidine
Methadone
Oxycodone
Sufentanil
Alfentanil
Remifentanil

2

Strong opioid agonists - adm

Fentanyl - parenteral, transdermal, sublingual, buccal.
Meperidine, methadone and morphine - oral and parenteral.
Oxycodone - oral
Sufentanil - parenteral
Remifentanil - only IV infusion

3

Long-acting strong opioid agonist

Methadone.

4

Strong opioid agonists with active metabolites

Meperidine
Morphine

5

Morphine - MOA

6-glucoronide metabolite is more active than morphine.

6

Morphine - indications

Severe pain associated with trauma, MI, cancer.
Chronic pain.
Pain after major surgery.

7

Derivatives of fentanyl - 3 drugs

Sufentanil
Alfentanil
Remifentanil

8

Most potent opioid agonists

Fentanyl, sufentanil, alfentanil, remifentanil.

9

Fentanyl and derivatives - indications

Severe or chronic pain.
Pre- and postoperative as adjunct to general anesthesia.

10

Fentanyl - adverse effects

Truncal rigidity (when used as adjunct to parenteral anesthesia).
Less nausea.

11

Strong opioid agonist with ultra rapid onset of action

Remifentanil. Recovery within 5-10 min

12

Strong opioid agonist with no antitussive effect

Meperidine

13

Meperidine - indications

Obstetric or postsurgical analgesic (parenteral).
Moderate to severe pain (oral).
Short-term treatment of acute pain syndromes.

14

Meperidine - adverse effects

Toxic metabolite (normeperidine): CNS excitation, convulsions, tremors

15

Methadone - indications

Opioid dependence.
Chronic pain.

16

Oxycodone - administration

Orally, usually with nonopioid analgesic.

17

Oxycodone - indications

Moderate to severe pain