MODULE 1

Question 1

Intended for diagnosis, cure, mitigation, treatment, or prevention of disease

Answer 1

Drug

Question 2

Give the Dosage Forms:

Answer 2

Solid (tablet, capsule)
Semisolid (ointment, creams)
Liquids
Suspension
Emulsion

Question 3

Considered as drug delivery system as it release and deliver drugs to site of action

Answer 3

Drug products

Question 4

Designed to meet patient needs such as Palatability, Convenience, and Safety

Answer 4

Drug products

Question 5

Examines the interrelationships of physical/chemical properties of drug

Answer 5

Biopharmaceutics

Question 6

Rate and extent of drug absorption

Answer 6

Bioavailability

Question 7

Measures the availability of the drug

Answer 7

Bioavailability

Question 8

Described as the sequence of events that precedes elicitation of drugs therapeutic effect

Answer 8

Drug substance and Drug formulation

Question 9

Drug is released from dosage form

Answer 9

Liberation

Question 10

Where drug reached the site of action

Answer 10

Distribution

Question 11

Results when site of action reaches or exceeds the minimum effective concentration

Answer 11

Pharmacodynamic response

Question 12

Tiniest amount of drug that produce a pharmacologic effect

Answer 12

MEC

Question 13

It is where the Starting dose, Maintenance dose, Dosage form, and Dosing intervals are determined

Answer 13

Clinical trials

Question 14

Provides a scientific basis on product design and product development

Answer 14

Biopharmaceutics

Question 15

Most important steps in manufacturing process is termed what?

Answer 15

Critical manufacturing variable

Question 16

It involves Test apparatus and equipments and no involvement of Laboratory animals or humans.

Answer 16

In vitro methods

Question 17

It involves humans and laboratory animals

Answer 17

In vivo methods

Question 18

Science of kinetics of drug absorption, distribution and elimination.

Answer 18

Pharmacokinetics

Question 19

Description of drug distribution and elimination is often termed as what?

Answer 19

Drug disposition

Question 20

Pharmacokinetics involves 2 approaches/aspects. What are these?

Answer 20

Experimental aspect
Theoretical aspect

Question 21

Involves development of biologic sampling techniques, analytical methods for the measurement of drugs and metabolites

Answer 21

Experimental aspect

Question 22

Involves development of pharmacokinetics models that predicts drug disposition

Answer 22

Theoretical aspects

Question 23

Integral part of pharmacokinetic studies

Answer 23

Statistics

Question 24

Used for pharmacokinetic parameter estimation and data interpretation

Answer 24

Statistical methods

Question 25

FDA approved label

Answer 25

Package insert

Question 26

Drug concentration below MEC

Answer 26

Subtherapeutic

Question 27

Drug concentration above the MTC

Answer 27

Toxic response

Question 28

It involves multidisciplinary approach

Answer 28

Clinical pharmacokinetics

Question 29

Study of pharmacokinetic differences of drugs in various population

Answer 29

Population pharmacokinetics

Question 30

True or False Clinical pharmacokinetics is also applied to Therapeutic drug monitoring.

Answer 30

True

Question 31

Example of Prothrombin clotting time

Answer 31

WARFARIN / PLDTWG

Question 32

Drugs that are frequently monitored

Answer 32

Aminoglycosides Anticonvulsants

Question 33

Drugs that are closely monitored

Answer 33

Cancer chemotherapy

Question 34

Study of drug effect including distribution and disposition due to genetic differences. Is also the main reason why many new drugs have to be further studied

Answer 34

Pharmacogenetics

Question 35

Related field which emphasizes different aspects of genetic effect on drug response.

Answer 35

Pharmacogenomic

Question 36

Its measurements can confirm whether the drug dose is subtherapeutic or was not responsive to the drug therapy

Answer 36

Plasma drug concentration

Question 37

Study of the biochemical and physiological effects of drugs on body.

Answer 37

Pharmacodynamic

Question 38

Molecules that interacts with specific drugs to produce pharmacologic effect on body

Answer 38

Receptors

Question 39

Refers to the relationship between drug concentration and pharmacologic response.

Answer 39

Pharmacodynamic

Question 40

Refers to the dose (drug input to the body) and various measures of acute or integrated drug conc. & other biological fluids (Cmax, Cmin, Css)

Answer 40

Drug exposure

Question 41

Refers to direct measure of the pharmacologic effect of drug.

Answer 41

Drug response

Question 42

Provides information on safety and effectiveness of drug during development .

Answer 42

Toxicologic and Efficacy studies

Question 43

Application of pharmacokinetic principles to design, conduct, and interpretation of drug safety.

Answer 43

Toxicokinetics

Question 44

Aids in the interpretation of toxicologic findings in animals and extrapolation of resulting data to humans.

Answer 44

Toxicokinetic data

Question 45

Performed in animals during preclinical drug development.

Answer 45

Toxicokinetic studies

Question 46

Study of adverse effects of drugs and toxic substances such as poisons in body.

Answer 46

Clinical Toxicology

Question 47

Drugs frequently involved in toxicity cases includes:

Answer 47

Acetaminophen Salicylate Opiates TCAs

Question 48

Causes an increase in heart rate when given intravenously but has no observable effects on the heart when given orally.

Answer 48

Isoproterenol

Question 49

May differ from one drug to another containing the same drug, even the same route of administration.

Answer 49

Bioavailability

Question 50

Provides a scientific basis for drug design and drug development.

Answer 50

Biopharmaceutics

Question 51

May affect the drug product performance including the release of drug from drug product.

Answer 51

Excipient

Question 52

Science of kinetics of Drug absorption, distribution, and elimination - ( metabolism and excretion)

Answer 52

Pharmacokinetics

Question 53

The most important steps of the manufacturing process are termed what?

Answer 53

Critical manufacturing variable

Question 54

Main reason why many drugs still have to be further studied after regulatory approval.

Answer 54

Pharmacogenetics

Question 55

Is it desirable that this occurs at drug concentration higher relative to the therapeutic drug concentrations

Answer 55

Adverse drug reaction

Question 56

Oral

Answer 56

Mouth

Question 57

Sublingual

Answer 57

Under the tongue

Question 58

Parenteral

Answer 58

By injection

Question 59

Intraosseous

Answer 59

Bone

Question 60

Intra-articular

Answer 60

Joint

Question 61

Intrasynovial

Answer 61

Joint fluid area

Question 62

Aural

Answer 62

Ear