Module 1: Section 3 Flashcards
(18 cards)
Drug Action Factoirs
drug targets, drug response, efficacy and potency, theraputic range
drug targets
designed to interact with one target in body. (receptors)
receptors
molecule located outside or inside cell. activated by ligands - found in hormones and neurotransmitters. loacted all throughout body
opioid receptors
receptors in brain = bain releif, recptors in gastrointestinel tract = constipation
chemical reactions
antiacids neutralize stomach acid
physical chemical forces
cholestrymine = binds to bile acids, prevent reabsorbtion, increase elimination of bile salts used to make cholesterol
Drugs and receptors
drug mimics or blocks effect of ligand at receptor
agonists
drugs that stimulate and bind too receptor
antagonists
drugs that bind to and block response at recptor
drug dose relationship
intensity increases with dose
drug response
for drug to acheive desired response, activates many receptors at once
low doses
very little response observed, not many receptors activated
threshold
as dose increases, more receptors activated. threshold = number or recpetors needed to be eactivated befor ena effect can be seen
theraputic dose
small increase from threshold = large increase in response
maximal effect
increase in response not indefinite. once max reached, increase in dose has no effect on theraputic response
ED 50
dose of drug that results in 50 percent of maximal effects. also interpreted as dose of drug that will be effective in 50% of the population
potency
dose of drug required to produce response magnitude. saying drug A more potent than drug B = take less of drug a to acheive same result as drug B
theraputic range
minimum concentration for thereputic response and maximum concentration for unaccptable toxic response
