Module 2.5 Flashcards
In previous videos we saw
-We have looked at the strucutres of triglyceriedes nd phospolipids .
-W esw that tirglycerides have three fatty acid moleucles onded to one moleucle of glhycerol .
-Triglyceride moelcules are nonpolar making them hydrophobic (AKA insoluble in water .)
WHEREAS PHOSPHOLIPS
-Two fatty acids bonded to a glycerol .
-REMEMBER –> these fatty acids are hydrophillic .
-Flycerol is also bonded toa phosphate group .
-Phosphate group is higly charges , so this part of the moleucle is polar . Menaing the PHOSPHATE goup is hydrophillic .
MEANING WHAT BREH
-phospholips have ahydrophobic region consisting of the fatty cid .
-+a hydrophillic region consisiting of the phosphte grup .
Chceck sheet , rather than drawin a phosphatee=lipie , scientsits acc raw iy out like thi .
circle with two tails .
-AS a phospholipd contain both hydrohpilic region and hyrdophobic trhio , IF WE place them inw ater they arrange themslevs like this , CHECK SHEET .
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-the hydrophillic part of the phospholipd moelcules phosphte group can INTERACT WITH WATER .
-However ,t he hydrophobic parts in other words the FATTY ACIDS are buried int he center way from th water .
-SCIENTISTS cll this the phospholipid bilayer .
-PHOSPHOIPID bilayer is the BAISSI of ALL CELL mEMBRANES .
-Including the cell surface membrane and rhe memranes tha surround organelles , suc as lysosmes and mitochondira .
-Membranes carry out a range of functions inc ells .
One fucntion of phospholipd bilayers
-Act as BARRIERS betweent he internal contents of the cell and the external environemnt .
-OR , between the contents of n organele and cytoplasms .
-Someitmes memranes separare one part of an organelle froma nother part (we will see more detai into this when we looka t mitchodnira)/
second fucntion of phospholipid bilhyers
Mmebranes are also a locaion for chmeical eaxcctions (stages inr edpirtion )
third funciton of phospholipdi bilayer
membranes are also inovved in cell sinalling .
like we said before ,t he cell surfce membrane provides a barriwr between the cytoplasms and the ecternal enviornment of the cell .
BECAUSE the cell surfce membrane contrians a hydrophobic center and hydrohpbic moelcules such as steroid hormone can EASILY pass thorugh the cell memerane .
HOWEVER , the hydrohobic cener prevents hydrphillic water soluble moelcules frome sasily passing through /
As HYDROHPHILLIC SUBSANCES ARE POLAR AKA THEY HAVE CHARGE ,
-These substances cannot eaisly pass through the non-polar refion of the memrbane .
REMEMBER ; water moelcules can ass thorugh the cell memrbane even htough water moelcuesl re polar .
As Water moelcules are extremely smll .
-Even so , gthis tkes plce at a slow rate .
-The cell ,e,brane is based int he phospholipd bilayer , HOWEVER it contains other parts as well .
FIRST THING TO NOTIE
-Cells urfaxe memrbane contins a large number of portein moelcuels .
-Som of these portiens are onlyon one side of the memrbaine .
-Whereas oher poreins span the memrane frm onse side to the otoher .
-The cell ,e,brane is based int he phospholipd bilayer , HOWEVER it contains other parts as well . (2)
The cells urface memrbane also contains choelstrol (saw int eh videos on lpds .)
-SEE STRCUUTRE OF CHOESTROL ONS HEET .
Cholestrol moelcules hve a polar hydrophillic grouop at the end .
-This group cn effect the poar hwad gorups on the phospholipd moleucles .
*The rest f the cholesrrol moelcule is non-polar +hydophobic .
-This part of the cholestrol mopecule cana trxt the non-polar fatty acids int he phospholipds . .
-So ebcuse choelstorl interacts withphospholipids . IT increses the strenght of the cells ufrace merae .
Making the memrbane more stbale nd less liekly to et damaged .
Another unction of choelstrol .
-CholesroL ALSO REDUCES THE SIDE WAYS MOVMEMNT OF THE PHOSPHOLIPDS AND OTHER MOECLUSL ITHIN THE MERBAEN.
-Helping to cotnrol the fulididty of the memrbane .
-Preventing the memrane from becoming too fluid under wam condirons and too rigid under cool conditons .
final dfucntion of cholestrol
-by packing the spaces begtwween the phosphoipds , cholesrol helps o reduce he movemnt of warer soluble sacorss hr cells urfce memrane .
Scienitsts call the strucutre of the cell surface memrbane the FLUID MOSIC MODEL.
-Need to be able to describe wht his means .
-The word “fluid” because the phospholipd molcule cn mvoe around wit each layer .
Menang the moelcule is flexbile nd cn change shape .
-The word “mosic” as the membranes is studed with protien moelcules .
-The rrangeemtn of the poretein molcuels varies like tile in amosaic .
-Looking into detail into the porteins we find in the cell memranes
-All membanes can be divided into two different catgeories
-Intrinsi or intergal proteins .
-Extrinsic or perpherl protins .
Intrinisc porteins
are fully EMedded from onse side to the toehr .
-As they pass right thorugh the ipid bilayer . Inrinisc proteins hae hydrohphobic amino cids ont heoutside surface of hte portein .
-The h ydrohpbic aminoa cids cna interact with the hydrohllic fatty acid tils in phospholipd bilayer .
rane porteins can be divided into two categories
There are two types of intrinsic porteins . Wchi is one of them
-PROTEIN CHANNLESLS
-potein channels contain a channel running thoruhgh he center .
-This channel is lines with the hydrohpillic amino acids and filled with water moleucles .
-Protein channels allow water-soluble moelcules nd ions o diffus htourgh .
Another type of intrinsic porteins
Carruer porteins .
-These can change thier or postion to transger moelcules or ions fromo ne side of the merbane to theo hter .