Module 3.1 and 3.2 Flashcards

there is about hundrd cards tha have been repeates o keep tha tin mindd ...

1
Q

dUnicellular / singlecellular organism (amoeba)
-fresh water ponds

A

-all organisms re constanlty , eschaning materials , with their enviornment .
-e.g , amoeba carries out aerobic respirattion generae atp .
-oxygen , needed for aerobic respiration —> diffuses into he cel through the cell membrane .

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2
Q

-scientists call the cell membrane an exchange surface .
-when amoeba carries our respiration , it prouduces the gas co2 .
-this co2 diffuses out of the cel via the cell membrane ,

A

In microscopic organsisms _ amoeba organism , exhange all the substance it needs directly though the cell memerbane , There is two reasons for this .

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3
Q

reason one

A

-microsocopic organisms , relatively low rate of respiration as ehya rent ery active organsimss .

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4
Q

reasons two

A

relatively large compared to volue of the cell . SA:V ,
-calcukae sa;v ratio using this equation

s:volume ratio = surface area / volume

sa;v=24/8 =3:1 96/64=1.5:1 for example

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5
Q

-single cell organsisms have a large sa to volume ratio .

A

they can transfer all of the chemicals they need across the cell membrane .
-However , large multiceullar orgasims sa;V much less .

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6
Q

-some small multicellular organsisms do rely on diffusion across their body e.g flatowrm .

A

by evolvingg a very flat and thin body size all of the cells in the flat are clsoe to the surfce .
-so diffusion corss hte body urfce is sufficne in a fla surface .

-HOWEVER , LARGE MULTICeullar organsims sa : v can not what .
-So multiceullar organsism evovles two specialsied sytems to compensate .

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7
Q

evolving one

A

-evovled specialised gas exchange sytems –> very large surface area ( lungs in mammals gulls in gish .

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8
Q

evovling two

A

specialsied transport sytem to carry moelcules around their bodlood

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9
Q

Mammals have a very low surface to volume ratio .
-mammals are also very active animals , mammals maintain a constant body temp .

A

-this required , an increased rate of aerobic respiration .
for these reasons , mammals have an extremely high oxygen demand .

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10
Q

-mammals , get their oxygen from the air , via their lungs shown , structure of human breathing system .

A

-humans have two lungs which are found in the thorax chest activity .
-the lungs are protected by the ribs .
-The ribs also plays a role in breathing .
-Along , with the intercostal muscles and diaphragm .

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11
Q

stage one of breathing

A

-when humans breathe though their nose , air passes through the nasal cavity .

-hairs in the nasal cavity traps , dust particles and pathogens .
-the nasal cavity also warms and moistens the air before it enter the lungs .

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12
Q

stage two of breathing

A

-The air , then makes it way down a wide tube called the trachea .
-The air then makes it way down a wide tube calle the trachea .

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13
Q

the trachea two key adaptations which you need to learn .

A

-walls of the trachea contain cartilage which is a firm but flexible material .
-The cartilage prevent the walls of the trachea , for collapsing when we inhale .

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14
Q

-this diagram shows a view of the trachea looking down towards the lungs .

A

-as you can see the trachea is very close to the oesophagus , which is the tube carrying food to the stomach .
-Yu’ll notice that the cartilage in the trachea forms a c shape , rather than forming the complete rings ?

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15
Q

Why does it not form complete rings ?

A

The absence if cartilage in the region near the oesophagus allows the food to pass down the oesophagus easily .

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16
Q

What is the second adaptation of the trachea

A

The walls are lined with ciliated epithelial and goblet cells .
-Showing cells lining the walls of the trachea .

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17
Q

What s the role of goblet cells

A

Goblet cells secrete mucus which traps dust particles and pathogens .
-The ciliated epithelial cells have cilia extending from the cell membrane .
-T

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18
Q

What do the cilia do ?

A

The beating of the cilia moves the mucus to the throat .
-The mucus is then swallowed and the dust and pathogens are digested by the stomach enzymes .

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19
Q

Going back to our lungs , we can see trachea divide into two bronchi

A

two bronchus carries air into one of the lung .
-Just like the trachea , the bronchi contain cartilage ciliated epithelial and goblet cells .

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20
Q

What does each bronchus split into ?

A

Each bronchus splits forming progressively narrower airways called bronchioles .
-The walls of larger bronchioles are supported by cartilage , they also contain smooth muscle .

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21
Q

What happens when the smooth muscle reflexes ?

A

The bronchioles widen allowing more air to pass into the deeper part of the lungs .

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22
Q
A
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23
Q

Deep in the lungs the bronchioles are extremely narrow .
What do these bronchioles lead to ?

A

Air sacs , called alveoli .
-Alveoli are the sites of gas exchange .
-There are hundreds of millions of alveoli in the lungs . The internal walls of the alveoli are covered with a thin layer of moisture .

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24
Q

-Close up of the alveoli , the alveoli is covered with blood capillaries .,
What happens to the oxygen in the air ?

A

Oxygen in the air of the alveoli dissolves nt he mositure on the inside of the alveoli wall .
-The oxygen then diffuses into the red blood cells where it combines with haemoglobin .
-Carbon dioxide diffuses from the blood into the alvelar spcae .

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25
Q

Between the alveoli , are elastic fibres which stretch and recoil during breathing .

A

As we have seen , the alveoli is where gases diffuse in and out of the blood .

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26
Q

What is one way alveoli are adapted to maximise the rate of diffusion .

A

Hundreds of millions of alveoli , these provide a massive surface area for the diffusion of gases .

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27
Q

Check sheet for the close up of alveolus and blood capillaries .

A

Both he wall of the alveolus and the walls of the capillary are only one cell thick .
-This means there is a very short diffusion distance between the air in the alveolia nd red blood cells in the capillary .

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28
Q

The narrow diameter of the capillary means that the red blood cells are close tot he capillary wall .

A

This minimises diffusion distance .

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29
Q

The extensive capillary network means that once oxygen diffuses into the blood , what happens ?

A

It is rapidly carried away from the alveoli -This ensures there is always a steep concentration gradient for oxygen .

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30
Q

Co2 also has a steep concentration gradient ,a s more is continually brought to the alveoli int he blood stream .

A

these concentration gradients are also maintained by breathing , which brings fresh air into the alveoli .

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31
Q

This ensures there is always a high concentration of oxygen in the alveolar air .

A

as well as a low concentration of co2 , this helps to ensure a rapid rate of diffusion of these gases .

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32
Q

What is breathing also known as ?

A

Ventilation .
-Ventilation brings fresh air from outside of the body into the alveoli .
-THIS , increases the concentration of oxygen in the alveoli air spaces whilst decreasing the concentration of co2 .
-The effect of this , is to increase the concentration of these gases thus increasing the rate of reaction .

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33
Q

What is the mechanism for ventilation ?

A

Simplified version of the lungs .
-Ventilation involves the action of two sets of muscles .

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34
Q

Muscle one involved in ventilation

A

intercostal muscles - which lie between the ribs and the diaphragm .
-Which separates the thorax (chest cavity ) from the abdomen .
-The two sets of muscles work together to change the volume of the thorax .
-

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35
Q

What happens if we change the volume of the thorax ?

A

By changing the volume of the thorax , this changes the pressure of air in the lungs .
-The effect of this , is to draw air into the lungs (inhalation ) . Or to expel air from the lugs (exhalation )

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36
Q

There are the two sets of intercostal muscles . What are they ?

A

These are called the external and internal intercostal muscles as they are involved in regular breathing . focus on external
-The internal intercostal muscles are involved in stronger breathing , this is what happens when we inhale / breathe in .

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37
Q

Stage one of inhalation

A

during inhalation ,t he external intercostal muscles contract aka they shorten .
-this pulls the ribs upwards and outwards l

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38
Q

stage two of inhalaiton

A

at the same time ,t he diaphragm also contracts which causes it tot flatten . The effect of these is to increase the volume of the thorax and lungs .
-This reduces the air pressure in the lungs .

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39
Q

stage thee of inhalation

A

as the air pressure in he lungs is now less than atmosphere pressure , air is drawn into he lungs .
-air is moves into the alveoli and the elastic fibres between the alveoli stretch .

BECAUSE - inhalation involve muscles constrain , inhalation active process .

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40
Q
A
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41
Q
A
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42
Q

Stage one of exhalation

A

during regular breathing , exhalation is essentially process as the muscles relax .
-Therefore exhalation does not require a great deal of energy .

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43
Q

stage two of exhalation

A

-during exhalation ,the external intercostal muscles relax and return to their original length .

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44
Q

stage three of exhalation

A

the diaphragm also relaxes returning to its usual dhape .
-The effects of this is to reduce there volume of the thorax and lungs .
-now air pressure in the lungs is gretaher than atmospehrec pressure .
-air ispushed out of the lugns .

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45
Q

-The elastic fibres between the alveoli also recoil helping to push out he air

A

scientists call this elastic retraction .

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46
Q

volume of lungs changes when we inhale and exhale

A
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47
Q

lungs are surrounded by a pleural membrane .
what do theyd o ?

A

between these membranes there is plural fluid which acts as a lubricant as the lung volume changes

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48
Q

As we have seen . during regular breathing exhalation is mainly a passive process .

A

This is not the case ,when we exhale strongly , as during this internal intercostal macules contract as we exhale strongly .
-this pulls the ribs down and inwards forcing air out of the lungs .

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49
Q

At the same time , the external intercostal muscles relax

A

As the internal intercostal muscles relax which the external interoctysal muscles contract . Scientists descrier this as antagnote .

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50
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51
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52
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53
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54
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55
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56
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57
Q

Insects can be extremely active organisms so what would there oxygen demand be like ?

A

They would have a very high oxygen demand , for example , during flight .

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58
Q

Key , how have gas exchange systems evolved in insects ?

A

to provide oxygen directly to cells .
-although insects do have a specialised transport system , this transfers nutrients and not oxygen .

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59
Q

What are insects covered with ?

A

A protective exoskeleton made of the polysaccharide chitin .
-Gases such as oxygen and carbon dioxide do not easily pass though .
-so on the surface of the exoskeleton ,t here are small openings called spircales .

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60
Q

What do spiracles do ?

A

Spiracles allow gases such as oxygen and carbon dioxide to diffuse into the body of the insect .

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61
Q

What can spiracles leads to ?

A

Spircales can lead into a network of tubes called the trachea .
(trachea are relatively wide tubes with a diameter of around 1 mm) .

-trachea extends down into the body of t he insect .
-trachea are relatively wide tubes with a diameter of around 1 mm .

-trachea extends down and along the insect’s body .

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62
Q

what is the trachea reinforced with

A

spirals of chitin .
-the chitin prevents the trachea from collapsing example when an insect moves .

-extending from the trachea are very fine tubes called tracheoles .

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63
Q

What are the adaptations of tracheoles ?

A

Tracheoles have a diameter of around 1 micrometre , or less .
-In fact they are much narrower than shown in the diagram .
-each trachea is a single cell that has extended to form a hollowtube .

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64
Q

insects

A

-a huge number of tracheoles extend down inbetween the cells of the insects body .

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64
Q

adaptations 2 of tracheoles

A

unlike trachea , tracheoles are not supported by chitin .
-This is because tracheoles have such a narrow diameter and are extremely close to cells , there is a very short diffusion distance for gases moving between the cells and the tracheoles .

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65
Q

adaptation 3 of tracheoles

A

huge number of tracheoles provide a very large surface area for gas exchange .

-this allows insects to maintain a very rapid rate of aerobic respiration ( example flight ) .

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66
Q

What are the ends of the trachea filled with ?

A

They are filled with fluid also known as tracheal fluid .
-during intense activity , the cells around the tracheoles undergo anaerobic respiration .

-anaerobic respiration which produces lactic acid lowering the water potential of the cells .

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67
Q

what does lowering the water potential of cells do to the tracheal fluid ?

A

causes the water in the tracheal fluid to move into the cell .
-this reduces the volume of the tracheal fluid drawing air into the tracheoles .
-also shows more tracheole surround avoidable for diffusion of oxygen and carbon dioxide .

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68
Q

Is gas exchange active or passive in insects ?

A

It is essentially a passive process .
This is because , oxygen diffuses down its co2 gradient from a high concentration in the external air into the lower concentration .

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69
Q

describe co2 diffusion in insects

A

co2 , diffuses down its conc tracheoles gradient .
-with a relatively high concentration in the tracheoles out to the external air .

rate of diffusion decreases with distance meaning insects tend to be small .

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70
Q

smaller size of insects , reduces distance required for diffusion to take place .

A

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71
Q

However , what is one problem that insects have ?

A

This is loss of water .
-The walls of the tracheoles are moist and the ends contain tracheal fluid .

-Meaning , water vapour can diffuse out of an insect via the spiracles .

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72
Q

However , what is one problem that insects have ? (2)

A

muscular sphincter .

-This means insects can reduce water loss by closing their spiracle (example insects oxygen req)

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73
Q

ocr , –> how have some insects evolved to increase rate of gas exchange ?

A

-If , we look at insects ,w e can see they have three main body segments .
Head –> Thorax–> Abdomen
-Some insects can also contract muscles to change the volume of the thorax and abdomen .

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74
Q

ocr , –> how have some insects evolved to increase rate of gas exchange ? (2)

A

causing , pressure changes in the trachea pushing air in and out .
-this bulk movement is called mass movement .

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75
Q

-in some insects , the trachea contain expanding sections called air sacs .
-What are the adaptations of the air sacs ?

A

-changes in the volume of the thorax and the abdomen can squeeze the air sacs , causing air to move from the air sacs into the tracheoles . -insects can also use the oxygen in the air sacs during when the spiracles have been closed for water conservation .

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76
Q

Larger organisms , have a much lower surface area to volume ration , so what does this mean ?

A

The vast majority of cells are a large distance from the surface of organisms .

-also , large organsisms , are often , very active , and have a high demand of oxygen for aerobic respirations /

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77
Q

so , if larger organisms , cannot rely on diffusion alone for the exchange of material , what else do they rely on ?

A

-we have already seen , how insects fish and humans have specialised gas exchange systems .

-This ensures a very efficent gas exchnage sytem for oxygen and carbondioixde .

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78
Q

how have insects adapted to their gas exchange system ?

A

so that gases diffuse directly .

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79
Q

How does diffusion work in fish and humans ?

A

gases dissolve in blood , which acts as a transport system .
-The blood then moves around the circulatory system , transferring the gases between the cells and
the gas exchange system .

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80
Q

what else does blood transfer , other than oxygen ?

A

Other essential molecules like glucose and amino acids .
-when molecules are carried in a transport medium such as blood through a circulatory system , scientists call this mass transport .

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81
Q

circulatory system of fish (1)

A

deoxygenated blood , is pumped by the heart , through the blood vessels to the gills .

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82
Q

circulatory system of fish (2)

A

In the gills , blood passes though narrow blood vessels called capillaries .

-oxygen diffuses from the water into the blood .

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83
Q

circulatory system of fish (3)

A

the oxygenated blood now passes from the gills though the blood vessels to the body tissues .

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84
Q

circulatory system of fish (4)

A

when it reaches the body tissues , the blood again passes though narrow capillaries , where oxygen diffuses from the blood to the cells that needd it .

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85
Q

circulatory system of fish (5)

A

finally , the deoxygenated blood , now returns in blood vessels back to the heart .

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86
Q

circulatory system of fish (6)

A

so blood , only passes though the heart only once .
-as it moves around the circulatory system scientists call this a single circulatory system .

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87
Q

problem with single circulatory system ?

A

when the blood passes through two sets of narrow capillaries .
-firstly ,
-firstly , in the gills . and secondly , as it passes into the body tissues when the blood passes though capillaries’ , blood flows down and looses pressure .
-MEANING –> once ,, the blood passes though the gills , blood is moving relatively slowly .

-limiting how rapidly oxygen can be delivered to body cells .

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88
Q

circulatory system in mammals (1)

A

deoxygenated blood is pumped under high pressure from the heart to the lungs .

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89
Q

circulatory system in mammals (2)

A

in the lungs , blood passes though the narrow capillaries and oxygen diffuses from air into the blood.

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90
Q

circulatory system in mammals (3)

A

As the blood , has passed though the capillaries , it is moving slowly with lower pressure .

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91
Q

circulatory system in mammals (4)

A

however , now the oxygenated blood returns back to the heart . Pumping blood at high pressure around the body .

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92
Q

circulatory system in mammals (5)

A

as it passes though the body , blood passes through the capillaries and oxygen diffuses to the body cells .

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93
Q

circulatory system in mammals (6(

A

the low pressure , deoxygenated blood now makes it way back to the heart to be pumped again .

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94
Q

so double circualtory system , blood passes though twice

A

this makes sure the blood makes it ways to the body tissues rapidly and under high pressure .

-so a double circulatory system can carry oxygen more efficiently , than a single circulatory system .

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95
Q

what is a closed sytem ?

A

-fish and mammmals , blood is always contained in blood vessels as it travels form the heart . this is a closed ciruclaotry sytem .

-in a closed cirulatory sytem , blood can move relatively rapidly , and the amout of blood pumped to differen ooorgans can be controlled by constricting or dialiating blood vessels .

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96
Q

What is an open circulatory sytem ?

A

insects have it , insects do not contain blood .
-instead , they contain a fluid called haemolymph .
-haemolymph carries nutrients also like sugar’s but do not carry oxygens //

-haemolymph is pumped out of the insects heart and passes directly into the body cavity called haermoroel .

-moelcuels are then transferred , becween the haemolymp and body ells an d hten the haemolymph makes its way back into the heart .

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97
Q

what is key about haemolymph

A

It is not carried in Venule , so it is an example of an open circulatory system .
-as the haemolympg is not Carried in vessels and jf moves rapidly around the insect .
-Also. (!3 insect is nkg essily change or cannot of how how much is moving to different parts of its body .

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98
Q

What do arteries branch to form

A

They form narrow blood vessels called arterioles.
Arteries carry the blood to the capillaries from each organ .

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99
Q

How does molecules diffuse in the capillaries

A

-Morley les diffuse from the body cells back into the blood .
-finally . The blood then passes from capillary to blood vessels called Venules and the which carry the blood back k tk the heart .

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100
Q

What way does the arteries carry the blood ?

A

Arteries carry the blood away from the heart to the organs blood on the arteries is under high pressure .

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101
Q

What is the pulse ?

A

When the heart beats , a surge of even higher blood
Pressure is pushed down the arteries scientists call this
PULSE

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102
Q

What way does the heart beat even when the heart beats ?

A

It moved FORWARD
-cross ex goin of w typical artery
- although I should point out , that very large artistes can have a wide diameter

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103
Q

Adaptation of arteries

A

The first thing to notice is that the artery wall is relatively thick .
-l this alllsws the artery to withstand high pressure of the blood .

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104
Q

The walls of the artery consist of several layers

A

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105
Q

The outer layer of the artery EXPLAIN

A

The other layer of the artery is rich in the fibrous protein collagen .
-collagen plays a structural role in, strengthening the artery wall against the pressure of the blood .

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106
Q

Next , the artery has a layer containing smooth malice

A

When the smooth muscle contracts , the diameter of the artery narrows .
THis alllws the body to control how much blood flows to different organs .

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107
Q

Different between large and small muscles

A

Smaller arteries tend to have a greater proportion of SMOOTJ muscles than larger ateries .
-that js bevause smaller attire is okay a great role in controlling blood pressure

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108
Q

Next layer w shave is elastic fibres

A

Elastin fibres contain the protein elastin which can stretch .
/when the heart contracts a surge of high blood pressure passes down the artery .

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109
Q

-as fhe surge moves through , the elastic fibres stretch , fhen recoil , once the surge has passed .

A

Elastic recoil helps the blood moving smoothly forward , inbetween contractions of the heart .

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110
Q

What is the. Entrap. about of the artery. Called ? Lumen

A

The linen is where the blood flows through. Lumen is lined with a thin layer of endothelial cells .
- this presents a very smooth surface to reduce the friction as blood flows through .

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111
Q

What do arteries branch into ?

A

Smaller blood vessels called arterioles .

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112
Q

What is the job of the arterioles

A

The jobs of the arterioles is to deliverto to the capillaries .
-the walls of the arterioles contain the same layers as arteries . -but as you will see they differe in their relative thickness .

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113
Q

Blood pressure in arterioles

A

-the blood pressure is lower than in arteries and the effect of the pulse is weak . This means , that in arterioles the collagen - rich outer mager and the elastic kager are relatively thin compared to the arteries .

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114
Q

What about the smooth muscle layer in arterioles

A

-is
Much thicker than in arteries .
- that is because arterioles are invovled in. Contracting the amount of blood passing through the capillaries .

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115
Q

What happens when the smooth muscles on the arterioles contact

A

Blood flow through the cappillaties ir reduced .
-scientists call this vasoconstriction
/hwo ded fhe smooth muscle in the arteries relaxes .
- blood flow through the capillaries increases , scientists call this vasodilation .

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116
Q

When does vasodilation take place ?

A

Vasodilation takes place when an organ requires an in increased amount of oxygen .

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117
Q

There is an extensive network of.Capillaries in every organ ?

A

As you can see , cappilladies are extensively branched and no body cell is very far from a capillary .

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118
Q

What is a network of capillaries called ?
What happens here ?

A

It is called a capillary bed .
_the capillary hed is where substances are e change between the blood and body cells .
-for example , oxygen and glucose diffuse from the blood to the body cells .

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119
Q

How do waste products diffuse ?

A

Waste products such as carbon dioxide diffuse from the cells back to the blood .

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120
Q

What does the extensive branching of capillaries provide ?

A

It provides a massive surface area for the exchange of. Materials .
- the structure of capillaries has evolved tk maximise the rate of diffusion for molecules such as oxygen .

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121
Q

What are the walls of capillaries like in the blood vessels ?

A

They ade extremely thin walls
-in fact , the walls of the capillaries consist of a single layer of endothelial cells .

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122
Q

What is the outside membrane like of capillaries ?

A

There is a thin membrane called the basement membrane .
-consists of a single layer of cells .
-making there is a short diffusion distance between the blood and the cells near the capillary .

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123
Q

Why does the shift diffuse distance of the capillaries help ?

A

-it increases the rate of diffusion for molecules .
-between the blood and the cells for example oxygen and carbon dioxide .

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124
Q

What is the diameter of the capillary lumen like compared to. Red blood cell

A

It is only slighted higher than a red blood cell .
—this means that when red blood cells pass through the capillary , they are pressed against the capillary wall .

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125
Q

What is the effect of the red blood cells being pressed against the wall !

A

This reduces the distance for diffusion fo oxygen .
-from the red blood s tk the tissue cells .
- as the lumen of the capillaries is only slightly wider than a red blood cell .

-meaning ew e blood cells reve
Though capillaries in a single file. /

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126
Q

What does it mean as red blood cells are travelling in single file ?

A

Because of this , red blood cells
Love though the capillaries
More
Slowly than on arteries and arterioles .
-this relative movement , increases the time available for molecules to diffuse in and out of the blood S

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127
Q

Last adaptation of capillaries
-if we look at the capillaries we can see gaps between endothelial cells .

A

These gaps allow fluid to pass out of the blood and scientists flak this tissue fluid .
- tissue fluid ? Bathes the cells providing essential molecules such as glucose and amino acids .

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128
Q

What do the gals in the capillary wall do ?

A

Allow white blood cells to leave the blood steam .

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129
Q

Where does the blood goe after it passes though the capillary ?

A

It makes its way though very small veins called the venules .

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130
Q

What do venules connect into . S

A

Venules connect into larger veins .
- these veins carry deoxygenated blood to the venavava where it passes into the heart .

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131
Q

How does blood in the Venules travel ?

A

Unlike arteries the blood in the Venules and veins flow under flow pressure and it is not travelling in pulses .
-this means that the structure of the veins is different to the arteries .

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132
Q

Why do veins have thinner s than arteries ?

A

This is because the walls of the veins do not need to withstand high blood pressure.

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133
Q

Why do veins have a larger lumen ?

A

To carry a greater volume of blood compared to the arteries .
- the smooth muscle layer and the elastic.are thinner in veins compared to the arteries .

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134
Q

Rememebr , the blood on veins does not travel in pulses , so there is no elastic. Recoil .

A

However , just like arteries. (!: lumen of the veins has an internal lining of endothelial cells . The smooth surfaces reduces the friction between the old and the walls of the veins .

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135
Q

Another important adaptation of grind er nerd yo learning that veins contain valves .

A

These valves keep the blood flowing in the forward direction.
- rememebr , the blood vessels are moving back to the heart .
Meaning blood may well be moving against gravity especially in legs and arms

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136
Q

Problem of blood in the veins ?

A

It is travelling slowly and under low pressure q

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137
Q

Quesfion ? What makes blood in the veins move back to the heart

A

Many veins are found lying between the skeletal muscles such as the large muscle of the arms and legs .
- when these muscles contract e.g during normal movement , they stayed: between the veins lying between them .

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138
Q

Blood flowing back to the heart part two

A

As we have seen xx veins have relatively thin walls . So when they squeeze they change shape .
This squeezing forces the blood along . If the blood moves forward then the valves. Remain open XD s
/however if the blood starts to move backwards fhen then the valves shut

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139
Q

The combined egg feed kd the muscles Darryl’s and the grind Ed erll Ed the action of the valves

A

Helps to keep the blood moving towards the heart .

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140
Q

What are the two main components of blood

A

Cells —> red blood cells which transport oxygen and white blood cells which play a role in the immunity .
- blood cells are suspended and cell fragments platelets are in a water solution invovled in blood clotting called blood plasma .

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141
Q

What does blood plasma contain

A

Blood plasma contains a range of dissolved molecules such as glucose and amino acids and ions such as sodium ions xx

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142
Q
  • blood plasma also cotnains dissolved oxygen which ?
A

Blood plasma also contains contains dissolved oxygen which doffusss out of the red blood cells. .
- another very important of blood plasma are proteins such as Albanian scientists refer to these as plasma proteins. .

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143
Q

What does the fluid do in the capillaries ?

A

The fluid passes out of the blood and bathed the tissue cells .
- scientists call it tissue fluid .

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144
Q

What does tissue fluid do ?

A

Tissue fluid leaves the bloood at the part of the capillary which is near the artery .
/ tissue fluid transfers molecules such as oxygen and tissue cells .

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145
Q

What do waste meocluels from tissue cells do ?

A

Did exmsd co2 pass into the tissue fluid
- the tissue fluid then truths bsck I my o the bloodstream. Af parts of the capillary which are near the vein ,

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146
Q

Stage one of how tissue fluids move on and out of the blood (1)

A

Tissue fluid is forced out of the blood at the arterial end of the blood capillary . And returns back to the blood at the venous end of the blood capillary ,

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147
Q

In order to understand the tissue fluid process we need to look at two competing factors

A

-. These are calllrd hydrostatic pressure and on proof oressure
/ structural end of capillary whrte tisdru fluid it reached - at the end of the capillary , the blood ha: .

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148
Q

end of the capillary the blood has just passed into an arteriole

A

-because of this , the blood at the arterial and of the capillary is still under relatively high pressure ,

-scientists call this hydrostatic pressure

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149
Q

what does hydrostatic pressure do ?

A

hydrostatic pressure tends to force fluid out of the blood into the tissue .
-remember , in blood plasma , got plasma proteins like abeli .

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150
Q

what do plasma proteins do ?

A

-plasma proteins are hydrophilic so they try to lower the water potential , of the blood plasma .

-because the plasma proteins , there is a tendency for water to move back into the blood by osmosis .
-scientists call this oncotic pressure .

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151
Q

what is the hydrostatic pressure like at the arterial end ?

A

the hydrostatic pressure is greater than the oncotic pressure .
-this means tissue fluid is forced out of the capillary through the gaps between the endothelial cells .
-scientists call this process ultrafiltration .

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152
Q

do proteins and blood plasma leave ?

A

no , they are too large so they remain in the blood plasma .

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153
Q

What is the hydrostatic pressure like ,a t the venous end ?

A

The hydrostatic pressure is much lower , as a large amount of water has left the blood .

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154
Q

how is the oncotic pressure like at the venous end ?

A

the oncotic pressure is still high due to the plasma proteins in the blood plasma .
- so , because of this ,a t the venous end , the hydrostatic pressure is less than the oncotic pressure . Causing , water to move back to the blood by osmosis .

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155
Q

Around 90% of the tissue fluid is reabsorbed back into the blood .
what happens to the remaining ten percent .

A

the remaining ten percent of the tissue fluid drains into a series of blind-ended valves called lymph capillaries .

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156
Q

What do lymph capillaries do ?

A

Lymph capillaries connect into large lymph vessels forming the lymphatic system .
-the lymphatic fluid moves along to the lymph vessels are squeezed by nearby skeletal muscles .

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157
Q

There are also valves in the lymph valves , why ?

A

valves into he lymph help to keep the lymph fluid .

-eventually , the lymph fluid returns to the blood stream via blood vessels under the collar bone .
-the lymphatic system also plays a role in immunity .

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158
Q

what is the activity of insects ?

A

insects can be extremely active organisms with a very high oxygen demand . For examples , during flight .

159
Q

What is key about the gas exchange in insects ?

A

gas exchange systems in insects have evolved to provide oxygen directly to cells .
-although insects do have a specialised transport system , this only tansfers nutrients not oxygen .

160
Q

What are insects covered in to aid gas exchange ?

A

insects are covered with a protective exoskeleton , made from the polysaccharide chitin .

161
Q

-gases such as oxygen and carbon dioxide cannot easily pass through the exoskeleton , so what does the exoskeleton have to aid this ?

A

-On the surface of the exoskeleton , we have small openings called spiracles .
-Spiracles allow gases such as oxygen and carbon dioxide to diffuse into the body of the insect .

162
Q

what do spiracles lead to ?

A

spiracles can lead into a network of tubes called trachea .
-The trachea are relatively wide tubes with a diameter of 1 mm .
-trachea extends down and along an insects body .

163
Q

what are the walls of the trachea reinforced with ?

A

they are reinforced with spirals of chitin .

164
Q

what does the chitin do in the trachea ?

A

-the chitin prevents the trachea from collapsing example when an insect moves .
-extending from the trachea are very fine tubes called tracheoles .

165
Q

give one adaptation of tracheoles

A

tracheoles have a diameter of around 1mm or less / So in fact , they are much mroe narrow then shown .
-each trachea is a single cell that has extendfed to forma hollow tues .

166
Q

where do the tracheoles extend into ?

A

down in-between the insects body .

167
Q

another adaptation of tracheoles

A

-unlike trachea , tracheoles are not supported by chitin . Because , tracheoles have such a narrow diameter and have an extremely close to cells .. there is a very short diffusion distance for gases moving in between the cells and for gases moving between he cells and the tracheoles .

168
Q

another adaptation of tracheoles (2)

A

this allows , oxygen to diffuse rapidly from the air in the trachea , into the cells .
-the oxygen is needed for aerobic respiration which produces the gas carbon dioxide .
-the carbon dioxide can also rapidly diffuse back into the air in the tracheoles .

169
Q

Give a third adaptation of tracheoles

A

huge number of tracheoles provide a very large surface area for gas exchange .
-this allows insects to maintain a very rapid rate of aerobic respiration (flight)
-the ends of the trachea are filled with fluid aka tracheal fluid .

170
Q

what happens during intense activity in insects

A

cells undergo anaerobic respiration .
-anaerobic respiration produces lactic acid , lowering the water potential of cells.#

-This then causes the water in the tracheal fluid to move into the cells .
-This reduces the volume of the trachea fluid drawing air into the tracheoles.
-also means more tracheole surface is available for diffusion of carbon dioxide and oxygen

171
Q

In many insects , gas exchange is essentially an a passive process , explain ?

A

-oxygen diffuses down the co2 gradient and from high concentrations in the external air .
-rate of diffusion decreases with distance meaning insects tend to be small .
-smaller size insects reduces distance for diffusion to take place .

172
Q

What is the significant problem that insects face ?

A

Loss of water .
-walls of the tracheoles are moist and the ends of the tracheoles contain tracheal fluid .
-meaning water vapour can diffuse out of the insect via the spiracles .

173
Q

however , what is the spiracles surrounded

A

each spiracle is surrounded by a muscular sphiniser, this means that insects can reduce water loss by closing their spiracles .
(e.g insects increase oxygen requirement )

174
Q

some insects have evolved to gas exchange

A

if we look at insects we can see we have three main body segments .

-head
-thorax
-abdomen .
-some insects can also contract muscles to change the volume of the thorax and the abdomen

-causing pressure changes in the trachea and tracheoles , pushing air in and out this bulk movement of air is called mass transports .

175
Q

in some insects , the trachea contain expanding sections called air sacs . Explain what the air sacs do ?

A

changes in the volume of the thorax and the abdomen can squeeze the air sac causing air to move from the airspaces into the tracheoles .

-insects can also use the oxygen in airsacs during … when spiracles have been closed for water conservation .

176
Q

what do larger organisms have compared to smaller organisms ? 1

A

-larger organisms have a much lower surface area to volume ration with the vast majority of cells a large distancer form he surface of the organisms .

177
Q

what do larger organisms have compared to smaller organisms ? 2

A

also larger organisms often are very active and have a high demand for aerobic respiration .
-meaning larger organisms cannot rely on diffusion alone for the diffusion if exchange in materials .

178
Q

we have already seen how insects fish and humans have specialised gas exchange systems.

however , what is different in humans and fish ?

A

gases dissolve in blood , which acts as a transport system .
-The blood , then moves around the circulatory system . transferring gases between the cells and gas exchange system .

179
Q

What other essential molecules does blood transfer ?

A

other essential molecules include glucose and amino acids .
-when molecules are carried in a transport medium such as blood through a circulatory system scientists call this mass transport .

180
Q

stage one of circulatory system of fish

A

deoxygenated blood is pumped by the heart through blood vessels to gills .

181
Q

stage two of the circulatory system of fish

A
  • in the gills , blood passes though narrow blood vessels called capillaries.
    -Oxygen diffuses from the water into the blood .
182
Q

stage three of the circulatory system of fish

A

the oxygenated blood now passes from the gills through the blood vessels to the body tissues .

183
Q

stage four of the circulatory system of fish

A

when it reaches the body tissues , the body again passes through narrow capillaries , where oxygen diffuses from the blood to the cells that need it .

184
Q

stage five of the circulatory system of fish

A

finally , the deoxygenated blood ,only returns in blood vessels back to the heart .

-so blood only passes , through the heart once , as i moves around the circulatory system , scientists call this a single circulatory system .

185
Q

what is the problem with the circulatory system of fish ?

A

when blood leaves the heart , the pressure of the blood is high , and the blood is moving rapidly .

-however blood then passes through narrow capillaries where oxygen diffuses from the blood to the cells that need it .

186
Q

stage six of the circulatory of fish

A

finally , the deoxygenated blood now returns in blood vessels back to the heart .-so blood only passes through the heart once .
-as it moves around the circulatory system ,scientist call this a single circulatory system :)

187
Q

problem with single circulatory system ?

A

when the blood leaves the heat , the pressure of the blood is high , and this means blood is moving rapidly ,..
-however , blood then passes through two sets of narrow capillaries

188
Q

problem with single circulatory system ? (2)

A

firstly in the gills and secondly as it passes through the body tissue when the blood passes through the capillaries , blood flows down and looses pressure .
-MEANING , once the blood passes through the gills it is moving relatively slowly .
-This limits , how rapidly oxygen can be delivered to the body cells

189
Q

circulatory system in mammals (1)

A

deoxygenated blood is pumped under high pressures from the heart to the lungs .

190
Q

circulatory system in mammals (2)

A

in the lungs , blood passes through narrow capillaries and oxygen diffuses from the air into the blood .

191
Q

circulatory system in mammals (3)

A

as the blood , has passed through the capillaries is its moving at a relatively lower pressure .

192
Q

circulatory system in mammals (4)

A

however , now oxygenated blood returns back to the heart , pumping blood at high pressure around the body .

193
Q

circulatory system in mammals (5)

A

as it passes through the body , blood passes through the capillaries and oxygen diffuses to the body cells .

194
Q

circulatory system in mammals (6)

A

the low pressure , deoxygenated blood molecules it way , back to the heart and to be pumped again .

195
Q

what happens in a double circulatory system ?

A

in a double circulatory system , blood passes through the heart twice .
-this ensures blood moves to the bodyt issues rapidly under high pressure .

-so a double circulatory system can something oxygen more efficiently than a single circulatory system .

196
Q

where is blood contained in fish and mammals ?

A

blood is always contained in blood vessels as it travels to and from the heart .
-scientists this is a closed circulatory system .

197
Q

what is a closed system ?

A

in a closed circulatory system , blood can move relatively rapidly , and the amount of blood passing to different organs can be controlled constricted by dilating blood vessels .

198
Q

WHat do insects have?

A

Insects have an open circulatory system . Insects do not contain blood .

199
Q

What do insects have instead of blood ?

A

Instead ,they contain a fluid called haemolymphs .
-Haemolymph carried nutrients aka sugars but does not carry oxygen .

200
Q

Where is haemolymph situated , how is it transported ?

A

haemolymph is pumped out of the insect’s heart and passes directly into the body cavity is called haemocoel .

201
Q

how is haemolymph transported ?

A

molecules are then transferred between the haemolymph and body cells and them haemolymph makes its way back into the heart .

-key ; haemolymph is not carried in vessels so it si an exmpa,e of an open circulatory system .

202
Q

speed of haemolymph

A

As the haemolpyh is not carried in vessels it does not move rapidly around the isnect .

-also the insect , does not easily change conc of hameolpyh moving to different parts of the body .

203
Q

What to arteries branch to form ?

A

arterioles

204
Q

what is the function of arterioles

A

arterioles carry the blood to the capillaries in each organism .

205
Q

how do molecules diffuse in the capillaries ?

A

In the capillaries , molecules diffuse from the blood to the cells example glucose and oxygen
-other molecules diffuse from the body back to the heart .

206
Q

what direction do arteries carry the blood ?

A

away from the heart to the organs .
-blood in the arteries is under high pressure .
-when the heart beats , a surge even high blood pressure is pushed down in the arteries calls this pulse .

207
Q

blood is always moving forwards between heart beats for arteries .

A

208
Q

cross section of arteries
-how thickkk is she

A

4-10mm is the cross section of a typical artery .
-however , some arteries do have a wide diameter .

209
Q

what is the first thing to notice about artery walls ?

A

artery walls are relatively thick .
-this allows the artery to withstand the high pressures of the blood .
-the walls of the arteries consist of several layers .

210
Q

what is the outer layer of the artery like ?
-what does it have that helps w structure ?

A

the outer layer is rich in fibrous protein collagen . Which we looked at previously .
-Collagen plays a role structurally , strengthening the artery wall against the pressure of the blood .

211
Q

explain the next layer of the artery that contains smooth muscle , not like isaacs bum ?

A

-when the smooth muscle contracts when isaac needs to take a dump , the diameter of the artery narrows .
-this allows body to control how much blood flows to different organs ,
like isaac controlling his plops .

212
Q

what do smaller arteries have compared to larger arteries and why ?

A

smaller arteries tend to have a GREATER proportion of smooth muscles than larger arteries .
-That’s because smaller arteries play a great role in controlling bloodflows .

213
Q

next layer we have in arteries is elastic fibres , what do they do part one

A

elastic fibres contain the protein elastin , which can stretch .
-when the heart contains a surge of high pressure , passes down the artery .

214
Q

elastic fibres part two

A

-as the surge moves through , the elastic fibres stretch , then recoi . one of the surges have passed .
-elastic recoil , helps the blood move smoothly forward , inbetween contractions of the heart .

215
Q

what is the central cavity of the artery called , what happens here ?

A

the central cavity of the artery is called the lumen .
-the lumen is where the blood flows though lumen is lined with a thin layer of endothelial cells.
-this presents a very smooth surface to reduce friction as blood flows throuh .

216
Q

what do arteries branch off into ? what do they do

A

arteries branch into smaller arterioles .
-arteries branch is to deliver blood to the capillaries .
-the wall of the arterioles contain the same layer as arteries .
-but they differ in their relative thickness

217
Q

what is the blood pressure like in the arterioles ?
-What is the effect of this on the pulse, what does this mean ?

A

;-The blood pressure is lower than in the arteries .
-the effect of this is that the pulse is weaker .

218
Q

What does a weaker pulse mean in the arterioles ?

A

This means that in the arterioles the collagen - rich outer layer .
-rich outER LAYER and the elastic layer are relatively thin compared to the cells .

219
Q

what is the thickness of the connective tissue and smooth muscle layer like and why ?

A

it is relatively thicker in arterioles compared to arteries .
-That’s because arterioles are involved in controlling the amount of blood passing through the capillaries .

220
Q

What happens when the smooth muscle in the arteries contract ?

A

-Blood flows through the capillaries is reduced .
-scientists call this vasoconstriction .

221
Q

what happens when the smooth muscles in the arteries relax ?

A

-blood flow increases through the capillaries scientists call this vasodilation .

222
Q

when does vasodilation happen ?

A

takes place when an organ requires an increased amount of oxygen .

223
Q

extensive networks of capillaries adaptations

A

capillaries are extensively broad and no body cell is very far from a capillary .
-a network of capillaries is called a capillary bed .

224
Q

What happens in the capillary beds ?

A

-The capillary beds are where substances are exchanged between the blood and body cells .
-for example , oxygen and glucose diffuse from the blood into the body cells .
-while , waste products such as carbon dioxide diffuse from the cells back into the blood .

225
Q

what does the extensive branching of capillaries provide ?
-give the adaptation

A

-the extensive branching provides a massive surface area for the exchange of materials .
-the structure of capillaries has evolved to maximise the rate of diffusion for molecules such as oxygen .

226
Q

what are the thickness of the walls of the capillaries like ?

A

capillaries have extremely thin walls.
-the walls consists of single endothelial cells .

227
Q

what is on the outside of the capillary walls ?

A

the outside of the capillary walls , there is a thin membrane called the basement membrane .

228
Q

what is the advantage of thin walls for capillaries ?

A

-as the capillary wall consists of a single layer of cells , this means that there is a very short diffusion distance between the blood and the cells near the capillary /
-this short distance increases the rate of diffusion of molecules between the blood and the cells for example oxygen and carbon dioxide .

229
Q

what is the diameter of the lumen of the capillary like , and what does this mean ?

A

-the diameter of the capillary lumen is only slightly bigger than red blood cells .
-this means that when red blood cells pass through the capillary , they are pressed against the capillary wall .

230
Q

adaptations of the lumen of the capillary part two

A

-this reduces the distance for the diffusion for the distance of diffusion of oxygen .,
-from the blood cells to the tissue cells .

231
Q

how do blood cells travel through the capillary ?

A

-this means red blood cells travel through capillaries in single file .
-because of this , red blood cells move through the capillaries more slowly in arteries than in arterioles .
-This relatively slow movement , increases the time available for molecules to diffuse in and out of the b lood /

232
Q

what is the final adaptation of capillaries

A

-if we look at the capillary wall , we can see small gaps between the endothelial cells .
-these gaps allow fluid to pass out of the blood , scientists call this tissue fluid .

233
Q

What does tissue fluid do ?

A

tissue fluid , bathes the cells , providing essential molecules such as glucose and amino acids .

234
Q

What do gaps in the capillary wall do ?

A

the gaps in the capillary wall , also allow white blood cells to leave the bloodstream

235
Q

once blood passes through the capillaries , where does it go ?

A

-It makes its way through very small veins called venules .

236
Q

where do veins connect to ?

A

venules , then connect into larger veins .
-these veins carry deoxygenated blood into the vena cava , where it passes into the heart .

237
Q

what is the pressure of the blood like in the veins and venules .

A

it is under low pressure , and it is not travelling in pulses .
-this means that the structure of the veins is different to arteries .

238
Q

why do veins have thinner walls ?

A

veins have thinner walls than arteries as the walls of the veins do not need to withstand high blood pressure .

239
Q

what is the lumen of the veins like and why ?

A

veins have a larger lumen and carry a greater volume of blood compared to arteries .

240
Q

what are the walls like in veins ? (endothelial etc )

A

the smooth muscle layer and the elastic layer are thinner in veins compared to the arteries .
-As the blood in the veins does not travel in pulses , so there is no elastic recoil .

241
Q

What is the internal lining of the lumen like ?

A

the internal lining of endothelial cells .
-the smooth surface reduces friction between the blood and the walls of the vein .

242
Q

veins contain valves , explain why

A

-these valves keep the blood flowing in the forward direction .
-remember , blood in veins is moving back to the heart , meaning blood may well be moving against gravity example in the legs and arms .

243
Q

problem , blood is travelling in veins at a relatively low pressure .
-question what makes blood in veins move back to the heart ?

A

-many veins are found lying between skeletal muscles , such as the large muscles in arms and legs .
-when the muscles contract , during movement , they squeeze between he veins lying between them .

244
Q

problem , blood is travelling in veins at a relatively low pressure .
-question what makes blood in veins move back to the heart ? part two

A

as we have seen , veins have relatively thin walls , so when they squeeze , they change shape .

-this squeezing , forces the blood along .if the blood moves forward then the valves remain open .
-however if the blood starts to move backward then the valves shut .

-tis combined effect of the muscles squeezing and the veins , as well as the action of the valves helps the blood move towards heart ,

245
Q

what is another factor that makes blood in the veins move back to the heart ?

A

when we inhale , the pressure of the chest cavity decreases .
-this decrease in pressure , helps t he blood in the chest veins to move forwards towards the heart .

246
Q

blood has two components , what is the first component ?

A

cells , red blood cells which transport oxygen and while blood cells play a role in immunity , blood cells are suspended and cell fragments and platelets in watery solutions , are involved in blood clotting , scientist call this blood plasma .

247
Q

What doe

A
248
Q

What does blood plasma contain ?

A

it contains a range of dissolved molecules such as glucose , amino acids and ions such as sodium ion na+ .

249
Q

what else does blood plasma contain ?

A

blood plasma also contains dissolved oxygen which diffuses out of the red blood cells .
-another very important part of blood plasma are proteins such as albumin .
-scientists refer to these as plasma proteins .

250
Q

what is the fluid like in the capillaries ?

A

fluid is pushed out of the blood and bathes the tissue cells .
-scientists call this tissue cells .

251
Q

what do waste products do in the tissue cells ?

A

waste molecules from the tissue cells such as co2 , pass into the tissue fluid .
-the tissue fluid then returns back into the blood stream and passes out of the capillary which is near the vein .

252
Q

how does tissue fluid move in and out of the blood part one ?

A

-tissue fluid is forced out of the blood at the arterial end of the blood capillary and reutrn back to the blood at the venous end of the capillary /

253
Q

in order to understand how tissue fluid is moving need to understand two competing factors , what are they ?

A

hydrostatic and oncotic pressure .

254
Q

what happens at the arterial end of the capillary ?

A

blood has just passes through an arteriole .
-because of this , the blood at the arterial end of the capillary , is still under relatively high pressure .
-scientists call this hydrostatic pressure ?

255
Q

what way does hydrostatic pressure push blood ?

A

hydrostatic pressure tends to force fluid out of the blood and into the tissue .
-remember in blood plasma , got plasma proteins as alb thatthing .

256
Q

what do plasma proteins do in relation to hydrostatic pressure.

A

plasma proteins are hydrophilic so they lower the water potential of the blood plasma .
- because of this , the plasma proteins , there is a tendency for the water to move back into the blood by osmosis .
-scientists call this oncotic pressure .

257
Q

what is the blood pressure like at the arterial end of the capillary ?

A

the hydrostatic pressure is greater than the oncotic pressure .
-this means that tissue fluid is forced out of the capillary through the gaps between the endothelial cells . scientist call this process ultrafilitiriatiom /

258
Q

does blood cells and plasma proteins leave the blood ?

A

no ,t hey are too big

259
Q

what happens at the venous end of the capillary ?

A

hydrostatic pressure is much lower as a large amount of water has left the blood .
-however , oncotic pressure is still high due to plasma proteins in the blood plasma , because of this , at the venous end , the hydrostatic pressure is less than the oncotic pressure .
-causing water to move in by osmosis into the blood

260
Q

how much of the tissue fluid is reabsorbed back into the blood

A

around 90 %

261
Q

what happens to the remaining ten percent of tissue fluid ?

A

it drains into a series of blind-ended vessels called lymph cappillaries .

262
Q

what happens in lymph capillaries

A

-lymph capillaries connect into large lymph vessels forming the lymphatic system .
-lymphatic fluid something when lymph vessels are squeezed by nearby skeletal muscles .

262
Q

what do valves in the lymph valves do ?

A

they gelp to keep the lymph fluid move forward .
-eventually , the lymph fluid returns to the blood system via blood vessels under the …

263
Q

where else does the lymphatic system play a crucial role ?

A

in immunity .

264
Q

what are red blood cells also known as and what do they do ?

A

erythrocytes , and they transport oxygen .

265
Q

adaptation one of erythrocytes ?

A

they have a biconcave structure giving them an increased surface area to volume ration , allowing oxygen to diffuse in and out rapidly .

266
Q

second adaptation of erythrocytes

A

each erythrocyte contains around 300 million molecules of the oxygen carrying protein haemoglobin .

267
Q

third adaptation of erythrocytes

A

although erythrocytes initially have a nucleus , this is lost before the erythrocytes enter circulation .
-absence of this means more erythrocytes volume is available to carry haemoglobin .

268
Q

describe the structure of haemoglobin

A

4 polypeptide chains .
-each binds to a prosthetic group haem
-iron ion fe2+
-so it is an example of a conjugated protein .

269
Q

check sheet for equation , and explain it
-is it a reversible reaction ? explain the effect of this

A

each of the fe2+ in the haem molecule can combine with one molecule of oxygen l.
-as there are four haem groups in each haemoglobin molecule .
–as it is a reversible reaction , oxyhaemoglobin can also release the oxygen when required .

270
Q

how can we measure the amount of oxygen that combines with haemoglobin ?
what does this thing show

A

-oxygen dissociation curve .
-on the y axis shows the percentage saturation of haemoglobin with oxygen . x axis is partial pressure of oxygen .

-as oxygen is a gas wee do not say it is the CONC of oxygen

271
Q

what shape does the graph have ?

A

s shape - sigmoid curve

272
Q

what does the graph tell us about haemoglobin ?

A

-sample of haemoglobin , as we increase the kpa , the percentage saturation of haemoglobin increase restively slowly .

273
Q

what does star one of the oxygen dissociation curve .show

A

at around 4 kpa , 25% saturation , each haemoglobin molecule
-bound to ne oxygen molecule .

-meaning low partial pressure of oxygen has haemoglobin has a low AFFINITY for oxygen .

274
Q

what does affinity mean

A

how strongly the oxygen binds to the haemoglobin

275
Q

what happens if one oxygen molecule binds ?

A

the affinity of haemoglobin of oxygen increases , and becomes much easier to bind to further oxygen molecules .

276
Q

what will happen if we increase the partial pressure of oxygen to around 7 KPA

A

WEACHIEVE 75% SATURATION , AKA 2 more oxygen molecules have bound .

277
Q

can explai8n the 75% saturation by looking at the structure of haemoglobin molecule

A

remember , haem contians 4 polypeptides .
-each polypeptide contains 4 haem groups whhich can bind to oxygen .

-if there is NO oxygen , then rthe haem graph will show low affinity for oxygen moelcules .

278
Q

what does a low affinity for oxygen mean ?

A

this means it takes a relatively large partial pressure for oxygen , so the first oxygen molecule can bind to a haem group .

-however , when one oxygen binds , the quaternary structure of the haemoglobin molecule changes .

-this now increases the affinity of the haem groups for oxygen .

279
Q

so binding more oxygen molecules …

A

only ,,, protein haemoglobin .

280
Q

when does partial pressure of oxygen decrease ?

A

-as tissue cells take up oxygen for aerboic respiration .

281
Q

-at a certain partial pressure , an average of oxygen molecule can now what , and what does this mean ?

A

one oxygen molecule can now unload each haemoglobin molecule .
-when one oxygen molecule unloads , this changes the quaternary structure of the haemoglobin and the effect of this is to reduce the affinity of the haem groups for oxygen .

282
Q

what happens to the pressure of the blood , if the blood passes though a very active site for example muscles

A

then the partial pressure of oxygen will fall even further .
-as the haemoglobin has a reduced affinity for oxygen it is now more easy for oxygen molecules to unload .

283
Q

another factor that needs to be considered is the partial pressure of co2 , and the effect it has on the oxygen dissociation curve .

A

-highlighted line in yellow , shows the carbon dioxide .
-shows haemoglobin when the co2 , is relatively low , partial pressure of c02 increased , in muscle tissue .

284
Q

what way does co2 , shift the curve ?

A

it shifts the oxygen dissociation curve to the right .
-what this means is that co2 k,, causes the oxygen affinity of haemoglobin o decrease , scientist call this the bohr effect .

285
Q

explain the bohr effect using the graph

A

if the partial pressure of co2 is low , then the haemoglobin is 75% saturated at a partial pressure of o2 at 7kpa ;/

286
Q

what is the partial pressure of oxygen , when partial pressure of co2 is high ?

A

then the haemoglobin is only 25 % saturated at the same partial pressure of 02 ,a s before .
-so the effect of co2 , is to reduce the affinity of haemoglobin for oxygen .

287
Q

start with this cardd

  • a relatively small increase in the oxygen partial pressure , what do scientist call this ?
A

positive cooperativity .

288
Q

why does the fourth haem group , only bind to oxygen at a fairly high partial pressure ?

A

that is because , 3 of the 4 haem groups have already been filled .
-so the chances of an oxygen molecule colliding with a 4th haem gorop is relatively low .

289
Q

where is the partial pressure of oxygen high , and what happens here ?

A

-in the alveoli , the partial pressure of oxygen is high and the haemoglobin , in red blood cells is around 97% saturated .

-

290
Q

-however m at a certain point , one oxygen molecule now unloads from the haemoglobin molecule .
-what does this unloading do to the structure .

A

-however m at a certain point , one oxygen molecule now unloads from the haemoglobin molecule .
-the effect of this is to decrease oxygen affinityo f the remaining haem groups .

291
Q

what will happen if the red blood cells moves into more active tissue ?

A

then the oxygen partial pressure will be even lower and two more oxygen molecules will rapidly unload from the haemoglobin molecule .

292
Q

what will happen when the final oxygen molecule unloads ?

A

-the partial pressure of oxygen has to be very low .
-this is unlikely to happen under normal conditions but it could take place in very active tissue example muscle tissue during intense exercise .

293
Q

if we plot the percentage of haemoglobin with oxygen against the partial pressure , what do we get ?

A

-oxygen dissociation curve .
-aka affinity of haemoglobin or oxygen , how strongly haemoglobin bind to oxygen depends on the partial pressure of oxygen .

294
Q

check sheet for rest .

A

295
Q

what is the first important effect co2 has

A

haemoglobin , has a higher affinity for oxygen , in conditions where the partial pressure of co2 is low , in the left hand side .

296
Q

In what places will oxygen and carbon dioxide be high ?

A

-in he lungs , haemoglobin has a high level of oxygen saturation .
-however , partial pressure of co2 , will be high when undergoing aerobic respiration , in muscle tissue .

297
Q

in blood , what can carbon dioxide form ?

A

it can form the , the acidic molecule carbonic acid .
-carbonic acid , released hydrogen ions h+ , the h+ combines with haemoglobin ,, causing the quaternary structure of haemoglobin to change .

-therefore , haemoglobin , has a lower affinity for oxygen , causing haemoglobin o unload oxygen more easily .

298
Q

how is the circulatory system of a foetus linked with maternal circulatory system ?

A

in the placenta , the fetal blood and the maternal blood pass closely to each other but they do not mix .

299
Q

what does the maternal blood have compared to the foetal blood ?

A

-the maternal blood has a high level of oxygen than foetal blood
-this causes , oxygen to diffuse across the placenta and into the foetal blood .
-to make oxygen transfer more efficiently , foetal haemoglobin is different to adult haemoglobin .

300
Q

look at the oxygen dissociation curve difference between foetus and an adult . What does it show ?

A

-oxygen dissociation curve has shifted to the left compared to adult haemoglobin .
-meaning foetal haemoglobin has a higher affinity for oxygen , then adult haemoglobinn .

301
Q

what does this higher affinity for oxygen do ?

A

it increases , the oxygen transfer across the placenta from the maternal haemoglobin to the foetal haemoglobin .

302
Q

notice that oxygen affinity of fetal haemoglobin is only slightly greater than in adult haemoglobin , why is this ?

A

-if the foetal haemoglobin had a very high oxygen affinity , this could prevent it from unlading oxygen the foetal tissues .

-so the oxygen affinity is only slightly greater than in adult .

303
Q

however , in foetal haemoglobin , to of the polypeptide changes are different than in adult haemoglobin .

A

due to this difference in gene , explain the foetus compared to adult .
-this difference , in polypeptide chains in the fetal haemoglobin means it has a higher oxygen affunity .

304
Q

what is the last factor to consider about foetal blood ?

A

carbon dioxide from the foetus , dissolve’s into the maternal blood . this carbon dioxide lowers the oxygen affinity for maternal haemoglobin .

-combined with a higher oxygen affinity of foetal haemoglobin , this makes oxygen transfer from maternal blood to foetal blood extremely efficient .

305
Q

all cells produce co2 , during what and what happens to the co2 ?

A

co2 , can be added to respiring tissues in the lungs where it is broken down .

306
Q

what is one way carbon dioxide can be transported in the blood ?

A

around 5% of the carbondioxide dissolves directly in the blood plasma

307
Q

what is another way carbon dioxide can be transported in the blood

A

around 20 % forms a compound with haemoglobin molecules in the red blood cells .
-remember , haemoglobin contains 4 polypeptide chain .
-in each of polypeptides the one amino aid has a free amino group .
-each of these amino groups can react with a molecule of co2 , so one molecule of haemoglobin can react with 4 molecules of co2 .

308
Q

look at the reversible reaction , when blood passes through respiring tissue
-how does co2 , get broken down in this reaction ?

A

the lack of carbon dioxide is high and Carboxyhaemoglobin , forms .

-however , in the lungs , the level of carbon dioxide is low and the carboaminohaemoglobin breaks down releasing co2 .

309
Q

now we have seen how around 25 & of the co2 is in the blood .
-how is the remaining 75 % transported ?

A

as hydrogen carbonate ion sin the blood plasma .

310
Q

explain the next reversible reaction with carbon dioxide and water

A

-as you can se , this is a reversible reaction , this reaction usually takes place slowly , however , the red blood cells contain an enzyme which speed up the reaction .

311
Q

what is the enzyme called , and what does it do ?

A

carbonic anhydrase .
-when co2 , diffuses into red blood cells it rapidly . forms carbonic acid .
-by cobverting co2 k into carbonic acid .
-this ensures the level of c02 , in red blood cells is low .

312
Q

what does a low concentration of co2 in red bloood cells mean ?

A
  • meaning there is a steep concentration gradient for co2 .
    -due to the steep concentration gradient , there is a high rate of diffusion of co2 , inot the blood cells .
313
Q

once the carbonic acid is formed , what does it dissocisate into ?

A

-hydrogen ions and hydrogen carbonate ion .

314
Q

what happens to the hydrogen carbonate ion ?

A

-the hydrogen carbonate ion now diffuses out of the red blood cells into the blood plasma .

315
Q

what is the problem with the hydrogen carbonate ion ? and how do we prevent this

A

-hydrogen carbonate ion has a negative charge .
-when the hydrogen carbonate ion now diffuses out of the red blood cell this creates a charge something .

316
Q

-what do we do to pevent the charge for hydrogen carbonate tion ?

A

to prevent this hdyrogen carbonate ion diffuses out of red blood cell .
-negative chlorate ion diffused out of he red blood cell , the chll prvents the charge imablance in red blood cell .

317
Q

we also release hydrogen ion , what does that do to the blood ?

A

-hydrogen ion , causes the ph of the blood to falls .

-to prevent htis , haemoglobin binds to thehydrogen ions aso haemoglobina cts as buffer we call it lactic acid .

318
Q

-when the level of of carbon dioxide is high , for example in respiring tissue , what happens ?

A

-the carbon dioxide forms carbonic acid and then the hydrogen carbonate ions .

319
Q

however mw hen the level of carbon dioxide is low , for example in the lungs what happens ?

A

-in this case , the level of carbon dioxide is low , so hydrogen carbonate ions diffuse back into the red blood cells in exchange for chloride ions .
-the hydrogen carbonate ions then combine with hydrogen ions to reform carbonic acid .

320
Q

-then when is carbonic acid broken down by

A

carbonic anhydrase , forming carbon dioxide .
-carbon dioxide diffuses out of the red blood cells and into the blood p0lasma .
-once in the blood plasma , the co2 , ca be exhaled from the lungs where the blood passes though the alveoli .

321
Q

once in the blood plasma , what happens to the co2

A

the co2 , can be exhaled from the lungs ,when the blood passes through the alveloi .

322
Q

how s the heart always shown ?

A

-heart is always shown as if you are facing the person .
-lhs of the heart is shown as the right of the diagram and vice versa .

323
Q

what is heart formed from

A

cardiac muscles and have two completely separate sides .

324
Q

what are the top two chambers of the heart ?

A

-top two are called atria , these have relatively thin muscular walls .

325
Q

what are the bottom two chambers of the heart ?

A

bottom two are called ventricles .
-ventricles have much thicker muscular walls than atria .

326
Q

how are the atria separated from the ventricles /

A

by the atrioventricular valves .

327
Q

what is the left and right av valve called ?

A

-called the bicupsid valve .
-the right av valve is called the trcapsid valve .

328
Q

what are the valves attached to ?

A

they are attached to tendons which ensure the valves open in the right direction .

329
Q

the right and left side of the heart are completely separated by what ,and what does it do ?

A

by a wall called the septum .
-the septum prevents any blood from passing directly between two sides of the heart .

330
Q

transport of blood part one

A

deoxygenated blood , enters the right atrium through the vena cava .
-the vena cava has two branches .

331
Q

what does the superior vena cava do ?

A

the superior vena cava brings blood from the head and upper parts of the body .

332
Q

what does the inferior vena cava do ?

A

brings blood from the lower parts of the body .

333
Q

transport of blood part two

A

the deoxygenated blood is now pumped from the right atrium to the right ventricle .
-the right ventricle now pumps the deoxygenated blood out of the heart to the lungs through the pulmonary artery /

334
Q

transport of blood part three

A

in the lungs , the blood becomes oxygenated , oxygenated blood now returns from the lungs back to the heart inthe pulmonary vein .

335
Q

transport of blood part 4

A

the pulmonary vein brings blood into the left atrium .
-blood then passes into the left ventricle which passes the blood out of a large blood vessel called the aorta .

336
Q

transport of blood part 5

A

the aorta , transfers deoxygenated blood to all the other parts of thebodt including the heart .

337
Q

what is the right side of the heart like compared to the left ?

A

you can see that the left ventricle is a thicker muscular wall than the right ventricle .
-that is because , the left ventricles pump blood around the whole body .
-whereas the right ventricles only pump blood to the lungs

338
Q

what parts contain valves ?

A

the pulmonary artery and the aorta

339
Q

what are the coronary arteries ?

A

-blood vessels that directly branch from the aorta .
-aka - coronary artery , this supplies the heart muscle with oxygen and nutrients .

340
Q

how is the heart beat initiated ?

A

the heart beat is initiated from within the heart itself .
-aka ,the heart does not need an external signal to beat .
-as the heart triggers its own beat , scientists say its myogenic .

341
Q

where is the pacemaker ?

A

pacemarker is in the right astrium
-sinatrial node san aka pacemaker .

342
Q

how does a pacemaker work ?

A
  • the cells in the san , depolarise , they become electrically excited .
    -this triggers a wave of electrical excitation to spread across the atria ,causing the atria to contract .
343
Q

what is the contraction of the atria called

A

the systole .

344
Q

the wave of electrical excitation , crossing the atria cannot directly pass down the ventricles , why ?

A

that is because the ventricles are separated from the atria , by a layer of non-conducting tissue .
-this layer of tissue , will not pass the electrical excitation through it .

345
Q

between the atria , there is another group of specialised cells , what are they called and what do they do ?

A

atrioventricular node - avn .
-the avn is connected to conducting fibres called parylune fibres .

346
Q

what do the parlyne fibres do ?

A

initially , the parlyne fibres are budnled together , scientits call this the b unde . -

347
Q

what do the parlyne fibred so ?

A

-run down to the apex .
-or abse of the heart and then up the walls of the ventricles .

348
Q

what do the atrioventricular valves do ?

A

they detect the elastic sxcitation passing over the atria .

-after a short delay , the avn , then transmits the electrical excitrtation down the parlyne fibred , this eletrical excitation causes the ventricles to contract .

349
Q

where do the ventricles contract ?

A

from the apex upwards .
-this ensures maximum volum eof blood is pumpd out of the ventircles .

350
Q

why is there a slight delayw hen avn triggers electrical excitation ?

A

this ensures that the ventricles contract after the atria has contracted .

351
Q

what is blood moving to the heart in what cycle ?

A

the cardiac cycle

352
Q

key word in cardiac cycle - systole , what does it mean ?

A

contracting – example atria systole , contraction of the atria .

353
Q

key word in the cardiac cycle - diastole , what does it mean ?

A

diastole means relaxing , example ventricualr diastole , relaxation of the ventricles .

354
Q

cardiac cycle stage one

A

both the atria and ventricles are in diastole , aka they are relaxed .
-blood flows into the atria via the vena cava and pulmonary vein .
-causing the pressure in the atria to rise .

355
Q

cardiac cycle stage two

A

at a certain point ,the pressure in the atria , is greater than the pressure in the ventricles , causing the atrioventricualr valves to open .
-allowing blood to flow down from the atria into the ventricles .

356
Q

cardiac cycle part three

A

now , the atria contract ,a ka atrial systole takes place .
-this pushes the remaining blood from the atria down to the ventricles .

357
Q

cardiac cycle part four

A

-after a short period of time , the ventricles contract aka they enter ventricular systole .,
-pressure in the ventricles now rise rapidly .
-because the ventricular pressure is now greater than the arterial pressure , the atrioventricular valve closes .
-

358
Q

why does the atrioventricular valve close ?

A

as this prevents any blood from moving back into the atria from the ventricles .

359
Q

cardiac cycle part five

A

the semilunar valves and in the pulmonary aorta are all open .

360
Q

cardiac cycle part six

A

blood is pumped out of the ventricles to the heart .
-you will notice when the ventricles contracted ,t he atria are relaxed.

361
Q

cardiac cycle part seven

A

finally , the ventricles relax . aka they enter ventricular diastole .
-at some point , the pressure in the ventricles falls below the pressure in the pulmonary artery and the aorta .

362
Q

cardiac cycle part 8

A

this causes , the semilunar valve to shut .
-preventing blood from flowing back into the ventricles , at this point hear is ready to enter next cardiac cycle .

363
Q

scientists have determined the blood pressure in different places of the heart during the cardiac cycle , what does the graph show ?

A

-graph applies to the left side of the heart .
-top graph shows the pressure changes taking place .
-bottom graph shows valve of left ventricle .

364
Q

reference keys

A

top graph first , shows pressure in left atrium .
black line pressure in left ventricle
blue line shows pressure ina orta - which takes blood out of the ventricle .

365
Q

(focus on black line ) –> what does star one show ?

A

at the start , the left atrium is undergoing systole .
-aka contracts , causing the pressure in the left atrium to increase .

-the atrioventricular valve is also open , so blood flows down the left ventricle causing pressure of left ventricle to increase .

366
Q

what does star two show (black line focus )

A

now the left ventricle contracts , aka enters systole , pressure in the elft ventricle massively increases .
-as the pressure in the left ventricle is now greater than in the left atrium ,t he atrioventricular valve shuts .

367
Q

what does star three show ?

A

when the pressure in the left ventricle is now greater than in the aorta , the semi-lunar valve in the aorta opens .
-blood now flows out of the left ventricle through the aorta .

368
Q

what does star four show

A

the pressure in the left ventricle now falls as the blood is leaving .

369
Q

what does star five show ?

A

at a certain point , the pressure in the left ventricle is less than in the aorta .
-now the semilunar valve in the aorta closes preventing blood from being drawn back into the ventricle .

370
Q

what hap[pens while the left ventricle is contracting ?

A

the left atrium is relaxing , (yellow line ) .
-this means the left atrium is now refilling with blood .

371
Q

focus on yellow line part two

A

the left ventricle begins to relax , causing the pressure of the left ventricle to fall .
-eventually , the pressure in the left ventricle falls bellow the pressure in the left atrium .
-at this point ,the atrioventricular valve opens and blood begins ro now move into the left ventricle form the left atrium .

372
Q

what happens as the atria and ventricles refill ?

A

the heart is ready to enter the next cardiac cycle /

373
Q

what does star six do ?

A
  • we can see , blood volume increased as it is pumped into the left ventricle where the atrium contracts .
374
Q

what does star seven show

A

when the left ventricle contracts , the blood valve falls as blood moves out through the aorta.

375
Q

what does star eight show

A

finally the blood volume increases and again , when left ventricle relaxes . blood flows down from left atrium l

376
Q

How can we analyse the electrical activity of the heart ?

A

by attaching electrodes to the surface of the skin .

377
Q

check the sheet , what does the pattern show , and what does it tell us ?

A

-the resulting trace is called an electrocardiogram / ECG
-pattern of ecg tells us what is taking place in the heart , this can be divided into three sections .

378
Q

what does the p wave show ?

A

p wave shows the contraction of the atria , aka atrial systole

379
Q

what does the qrs wave show ?

A

it shows the contraction of the ventricles aka ventricular systole .

380
Q

what does the t wave show ?

A

T wave shows the relaxation of the ventricles aka ventricular diastole .

381
Q

how does the ecg correlate with the cardiac cycle ?

A

-we can map the ecg onto the graph we saw of pressure changes during the cardiac cycle .
-can see the different stages during a heart beat .

382
Q

check the ecg , what does each division show , and how is heart rate measured ?

A

-each division shows 0.2 seconds , The heart rate is showed in beats per minute

383
Q

how do we calculate bpm ?

A

-measure the time take for one heart beat .
-to do this , measure the time between the start of the p wave and the start of the next p wave .

384
Q

Some people have a slow resting heart rate , what is this called .

A

-If the heart rate is below 60 bpm , this s called bradycardia .

385
Q

when can bradycardia happen ?

A

bradycardia can happen due to athletic training ,
-which increases the stroke volume of the heart .

386
Q

what is the bpm like in bradycardia ,and why ?

A

-as the heart pumps a greater blood volume per beat , the number of bats per minute decreases .

387
Q

why may someone develop bradycardia ?

A

some people may develop bradycardia as a result of a disease , these people may require an artificial pacemaker .

388
Q

some people have a heart rate greater than 100 bpm , what is this called ?

A

This is called tachycardia .
-tachycardia , can be caused by short term effects such as fear , panic or exercise .

389
Q

what cab long term tachycardia be caused by ?

A

problems with the sinoatrial node , or other medical problems .
-in this surgery or drugs may be required .

390
Q

what is an example of an ectopic heartbeat ?

A

an ectopic heartbeat is an extra heartbeat , that is not part of the heart’s usual rhythm .
-heart contracts again before first contraction has finished . This is then followed by a short pause , before the normal rhythm continues .

391
Q

what is the severity of an ectopic heartbeat ?

A

ectopic heartbeat is relatively common and does not pose any health risks .
-however , if a person experiences an ectopic heartbeat , that might indicate a more serious heart condition .

392
Q

what happens in atrial fibrillation ?

A

-in atrial fibrillation , irregular waves of electrical excitation pass over the atria .
-this causes the atria to contract randomly and rapidly up to several times per minute .

393
Q

is the electrical excitation transmitted to the ventricles ?

A

no , as you can see , the ventricles contract less frequently m than the atria .
-as the normal rhythm of he heart is disrupted ,atrial fibrillation is a type of arrhythmia .

394
Q

how is atrial fibrillation treated ?

A

atrial fibrillation is treated with medication or surgery .